公开(公告)号：EP0429430A2

公开(公告)日：1991-05-29

申请号：EP91100080.0

申请日：1985-09-10

申请人： MECT CORPORATION

发明人： Ogasawara, Sadanori ,  Hanafusa, Takashi ,  Kariya, Katsuhide, ,  Ito, Masayoshi ,  Shitori, Yoshiyasu

IPC分类号： A61K31/70

CPC分类号： A61K31/70 ,  C07H13/04

摘要： An expectorant capable of acting on the rheological properties of sputum and capable of directly promoting the ciliary motion. The expectorant contains N-acetylneuraminic acid

摘要翻译： 祛痰剂能够对痰液的流变性能起作用，能直接促进睫状肌运动。 祛痰剂含有N-乙酰神经氨酸

公开(公告)号：EP0256485A3

公开(公告)日：1990-06-13

申请号：EP87111579.6

申请日：1987-08-10

申请人： MECT CORPORATION

发明人： Yoshimura, Shoji ,  Tani, Yoichiro ,  Matsuzaki, Youzi ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Ogawa, Tomoya

IPC分类号： C07H15/04 ,  A61K31/70

CPC分类号： C07H15/04

摘要： The present invention relates to a new process for preparing 3-O-(sodium(5-acetamide-3,5-dideoxy-alpha-D-glycero-­D-galacto-2-noneuro pyranosyl)onate-1,2-di-O-tetradecyl-Sn-­glycerol (3).

公开(公告)号：EP0315973A3

公开(公告)日：1990-05-16

申请号：EP88118659.7

申请日：1988-11-09

申请人： MECT CORPORATION

发明人： Yoshimura, Shoji ,  Matsuzaki, Yuzi ,  Sugimoto, Mamoru ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Ogawa, Tomoya

IPC分类号： C07H15/06 ,  A61K31/70 ,  C07H15/04

CPC分类号： C07H15/06

摘要： Sialocylglycerolipids represented by the following general formula:
wherein R 1 represents a hydrogen atom or a group CH 3 CO-; R 2 represents an alkali metal, a hydrogen atom or a lower alkyl group; R 3 represents a hydrogen atom or a group C n H 2n+1 - (n is an integer ranging from 1 to 30); and R 4 represents a group C m H 2m+1 - (m is an integer ranging from 1 to 30) are herein disclosed. They are prepared by treating a corresponding compound in an alkaline aqueous solvent. The method makes it possible to provide these compounds in a high yield by a simple processes.

摘要翻译： 由以下通式表示的唾液酸酯甘油脂：其中R 1表示氢原子或基团CH 3 CO-; R2代表碱金属，氢原子或低级烷基; R3代表氢原子或基团CnH2n + 1-（n是1-30的整数）; 和R4代表基团CmH2m + 1-（m是1-30的整数）。 它们通过在碱性含水溶剂中处理相应的化合物来制备。 该方法可以通过简单的方法以高收率提供这些化合物。

公开(公告)号：EP0332191A2

公开(公告)日：1989-09-13

申请号：EP89104199.8

申请日：1989-03-09

申请人： MECT CORPORATION

发明人： Yoshimura, Shoji ,  Matsuzaki, Yuzi ,  Sugimoto, Mamoru ,  Ito, Masayoshi ,  Ogawa, Tomoya

IPC分类号： C07H5/06 ,  A61K31/70

CPC分类号： C07H15/06

摘要： The present application discloses a new sialosyl glyceride having the following formula, which compound is useful as a remedy for nervous diseases, has an excellent compatibility with the living bodies, and is easily producible.
wherein R¹ represents a hydrogen atom or XCH₂CO- (X being a halogen atom), R² represents an alkali metal, a hydrogen atom or a lower alkyl group, R³ represents a hydrogen atom or -CO(CH₂)mCH₃, R⁴ represents -CO(CH₂)mCH₃ and m and n each represents a number of 0 to 30.

摘要翻译： 本申请公开了具有下式的新的唾液酸甘油酯，该化合物可用作神经疾病的补救剂，与活体具有优异的相容性，并且易于生产。 其中R 1表示氢原子或XCH 2 CO-（X为卤素原子），R 2表示碱金属，氢原子或低级烷基，R 3表示氢原子或 -CO（CH 2）m CH 3，R 4表示-CO（CH 2）m CH 3，m和n各自表示0〜30的数。

公开(公告)号：EP0315973A2

公开(公告)日：1989-05-17

申请号：EP88118659.7

申请日：1988-11-09

申请人： MECT CORPORATION

发明人： Yoshimura, Shoji ,  Matsuzaki, Yuzi ,  Sugimoto, Mamoru ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Ogawa, Tomoya

IPC分类号： C07H15/06 ,  A61K31/70 ,  C07H15/04

CPC分类号： C07H15/06

摘要： Sialocylglycerolipids represented by the following general formula:
wherein R 1 represents a hydrogen atom or a group CH 3 CO-; R 2 represents an alkali metal, a hydrogen atom or a lower alkyl group; R 3 represents a hydrogen atom or a group C n H 2n+1 - (n is an integer ranging from 1 to 30); and R 4 represents a group C m H 2m+1 - (m is an integer ranging from 1 to 30) are herein disclosed. They are prepared by treating a corresponding compound in an alkaline aqueous solvent. The method makes it possible to provide these compounds in a high yield by a simple processes.

摘要翻译： 由以下通式表示的唾液酸甘油脂：其中R 1表示氢原子或基团CH 3 CO-; R 2表示碱金属，氢原子或低级烷基; R 3表示氢原子或C n H 2n + 1-（n为1〜30的整数）的基团。 并且R 4表示基团C m H 2n + 1 - （m为1至30的整数）。 它们通过在碱性水溶剂中处理相应的化合物来制备。 该方法可以通过简单的方法以高产率提供这些化合物。

公开(公告)号：EP0273388A3

公开(公告)日：1989-04-26

申请号：EP87119132.6

申请日：1987-12-23

申请人： MECT CORPORATION

发明人： Yoshimura, Shoji ,  Shibayama, Shohei ,  Numata, Masaaki ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Ogawa, Tomoya

IPC分类号： C07H15/04 ,  C07H15/26 ,  A61K31/70 ,  B01J20/26

CPC分类号： C07H15/04 ,  A61K47/26

摘要： A sialic acid derivative having an active carbonyl group represented by the formula [I]:
(wherein R' represents hydrogen or acetyl group; R 2 represents hydrogen, a metal or a lower alkyl group; R 3 represents hydrogen, hydroxyl group, or a residue removed hydrogen from an alcohol portion of an active ester; Ac represents acetyl group; and n is 1 to 20, respectively). This sialic acid derivative [I] can be utilized as a starting material for various complex having a sialic acid in the molecule since it has an active carbonyl group in the molecule so that it shows high reactivity.

公开(公告)号：EP0260606A2

公开(公告)日：1988-03-23

申请号：EP87113263.5

申请日：1987-09-10

申请人： MECT CORPORATION ,  MITSUI TOATSU CHEMICALS, Inc.

发明人： Nagai, Yoshitaka ,  Awaya, Akira ,  Horikomi, Kazutoshi ,  Kobayashi, Hisashi ,  Mizuchi, Akira ,  Shitori, Yoshiyasu ,  Ito, Masayoshi ,  Ogawa, Tomoya

IPC分类号： A61K31/70

CPC分类号： A61K31/7004 ,  C07H15/04

摘要： A medicament composition for curing neurotic disturbance or disorder comprising a compound represented by the following formula (I) of:

摘要翻译： D：固化神经质扰动或紊乱，其包括由下式（I）表示的化合物的药物组合物

公开(公告)号：EP0255717A2

公开(公告)日：1988-02-10

申请号：EP87111254.6

申请日：1987-08-04

申请人： MECT CORPORATION

发明人： Ogawa, Tomoya ,  Sugimoto, Mamoru ,  Numata, Masaaki ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Nunomura, Shigeki

IPC分类号： C07H15/10 ,  C07H13/04 ,  A61K31/70

CPC分类号： C07H15/10 ,  C07H3/06

摘要： The present invention relates to ganglioside related compounds having. for example. the following formula:
where R 1 represents H or COCH 3 (hereinafter abbreviated to "Ac"); R 2 represents H or CH 3 ; and R 3 represents -OH,

or

These ganglioside related compounds are useful as membrane receptors, tumor markers, cell growth controlling substances, etc., and useful for immunotherapy for cancer, etc.

摘要翻译： 本发明涉及具有例如下式的神经节苷脂相关化合物：其中R 1表示H或COCH 3（以下简称为“Ac”）的CHEM> R2表示H或CH3; R3表示-OH，这些神经节苷脂相关化合物可用作膜受体，肿瘤标志物，细胞生长控制物质等，可用于癌症免疫治疗等。

公开(公告)号：EP0166442A3

公开(公告)日：1987-10-21

申请号：EP85107982

申请日：1985-06-27

申请人： RIKAGAKU KENKYUSHO ,  MECT Corporation

发明人： Ogawa, Tomoya ,  Sugimoto, Mamoru ,  Shitori, Yoshiyasu ,  Ito, Masayoshi

IPC分类号： C07H07/02 ,  C07H03/06 ,  C07H03/04 ,  C07H15/18

CPC分类号： C07H15/10 ,  C07H3/06 ,  C07H7/027 ,  C07H15/18

摘要： Novel sialic acid derivatives and galactose derivatives which are useful intermediate for the synthesis of gangliosides. Methods for the production of the sialic acid and galactose derivatives. Methods for the production of ganglioside GM 3 .

公开(公告)号：EP0194563A2

公开(公告)日：1986-09-17

申请号：EP86102857.9

申请日：1986-03-05

申请人： MECT Corporation

发明人： Shibayama, Shohei ,  Matsuzaki, Yuzi ,  Yoshimura, Shoji ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Ogawa, Tomoya

IPC分类号： C07H15/26 ,  A61K31/70

CPC分类号： C07H15/26

摘要： This invention provides a novel compound having a formula such as
This invention also provides a process for preparing such a compound. The novel compound has excellent immunological activity.