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    Medical devices and applications of polyhydroxyalkanoate polymers
    3.
    发明公开
    Medical devices and applications of polyhydroxyalkanoate polymers 有权
    MedizinischeGeräteund Anwendungen aus Polyhydroxyalkanoat-Polymeren

    公开(公告)号：EP2305324A1

    公开(公告)日：2011-04-06

    申请号：EP10075553.7

    申请日：2000-03-24

    申请人： METABOLIX, INC.

    发明人： Williams, Simon F ,  Martin, David P ,  Skraly, Frank

    IPC分类号： A61L31/14 ,  A61L17/12 ,  A61L27/18 ,  A61L27/58 ,  A61L31/06

    CPC分类号： A61L27/58 ,  A61F2/07 ,  A61F2210/0004 ,  A61K31/715 ,  A61L17/12 ,  A61L27/18 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08G63/06 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C08L67/04 ,  C12P7/625 ,  Y10S606/911

    摘要： Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

    摘要翻译： 由生物相容性聚羟基链烷酸酯形成或包括生物相容性聚羟基链烷酸酯的装置具有受控的降解速率，优选在生理条件下小于一年。 优选的装置包括缝线，缝线紧固件，弯液面修复装置，铆钉，钉，钉，螺钉（包括干涉螺钉），骨板和骨电镀系统，外科手术网，修复贴片，吊索，心血管贴片，矫形针 材料），粘附屏障，支架，引导组织修复/再生装置，关节软骨修复装置，神经导管，肌腱修复装置，房间隔缺损修复装置，心包块，填充剂和填充剂，静脉瓣，骨髓支架，半月板再生 器械，韧带和腱移植物，眼细胞植入物，脊髓融合笼，皮肤替代物，硬脑膜替代物，骨移植物替代物，骨榫，伤口敷料和止血剂。 聚羟基链烷酸酯可以含有由单体混合物形成的添加剂，或者在其主链中包括侧基或修饰，或者可以进行化学改性，以改变降解速率。 聚羟基链烷酸酯组合物还在生理条件下的期望时间范围内提供有利的机械性能，生物相容性和降解时间。

    Polyhydroxyalkanoate compositons having controlled degradation rates
    4.
    发明公开
    Polyhydroxyalkanoate compositons having controlled degradation rates 审中-公开
    具有可控降解速率的聚羟基链烷酸酯组合物

    公开(公告)号：EP2258742A1

    公开(公告)日：2010-12-08

    申请号：EP10075367.2

    申请日：1998-12-22

    申请人： METABOLIX, INC.

    发明人： Martin, David P ,  Skraly, Frank A ,  Williams, Simon F

    IPC分类号： C08G63/06 ,  C08G63/91 ,  C08K3/00 ,  C08K5/00 ,  C08J9/26 ,  C08J9/28 ,  C08L67/04 ,  C12P7/62 ,  A61K47/34 ,  A61L17/00 ,  A61L27/00 ,  A61L31/00 ,  C08G63/00

    CPC分类号： A61L31/06 ,  A61K9/1647 ,  A61K9/204 ,  A61K47/34 ,  A61K47/593 ,  A61L15/26 ,  A61L17/12 ,  A61L24/0042 ,  A61L26/0019 ,  A61L26/009 ,  A61L27/18 ,  A61L27/34 ,  A61L27/58 ,  A61L29/06 ,  A61L31/148 ,  C08G63/06 ,  C08G63/60 ,  C08G63/64 ,  C08G63/664 ,  C08G63/6852 ,  C08G63/6882 ,  C08J9/26 ,  C08J2201/044 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C08L67/04 ,  C08L101/00 ,  C12P7/625 ,  C08L2666/02

    摘要： The present application provides biocompatible medical implant comprising poly(4-hydroxybutyrate-co-hydroxyalkanoate) copolymer. The implant may, for example, be a device selected from guided tissue regeneration devices, tissue engineering devices, tissue engineering scaffolds, foams, coatings, meshes, microparticles, resorbable wound closure materials such as suturing and stapling materials, controlled release devices, drug delivery devices, cell encapsulation devices, targeted delivery devices, devices with biocompatible coatings, orthopedic devices, prosthetics, bone cements (including adhesives and/or structural fillers), diagnostic devices, rods, bone screws, pins, surgical sutures, stents, patches (such as hernial patches and pericardial patches), devices with vascular applications, and tubes suitable for the passage of bodily fluids. The application also provides a biocompatible polyhydroxyalkanoate that has a controlled degradation rate of less than one year under physiological conditions for use in medicine, optionally wherein the biocompatible polyhydroxyalkanoate is processed to form a medical device. The biocompatible polyhydroxyalkanoate may, for example, be produced by a process consisting of fermentation, enzymatic synthesis, chemical synthesis, melt processing, reactive blending, and recombinant techniques. The biocompatible polyhydroxyalkanoate may, for example, be produced by fermentation (a) using a co-feed, and/or (b) by a fermentation process that uses transgenic bacteria.

    摘要翻译： 本申请提供了包含聚（4-羟基丁酸酯 - 共 - 羟基链烷酸酯）共聚物的生物相容性医学植入物。 例如，植入物可以是选自引导的组织再生装置，组织工程装置，组织工程支架，泡沫，涂层，网状物，微粒，可再吸收的伤口闭合材料例如缝合和缝合材料，控释装置，药物输送 装置，细胞封装装置，靶向递送装置，具有生物相容涂层的装置，整形外科装置，假体，骨接合剂（包括粘合剂和/或结构填充物），诊断装置，棒，骨螺钉，针，手术缝合线，支架，贴片 作为疝补片和心包贴片），具有血管应用的装置和适于体液通过的管。 本申请还提供了生物相容性聚羟基链烷酸酯，其在用于医学的生理条件下具有小于一年的受控降解速率，任选地其中生物相容性聚羟基链烷酸酯被加工形成医疗装置。 生物相容性聚羟基链烷酸酯可以例如通过由发酵，酶促合成，化学合成，熔体加工，反应性共混和重组技术组成的工艺来生产。 生物相容性聚羟基链烷酸酯可以例如通过发酵（a）使用共同进料，和/或（b）通过使用转基因细菌的发酵过程来生产。