公开(公告)号：EP4373533A1

公开(公告)日：2024-05-29

申请号：EP22754740.3

申请日：2022-07-19

Applicant: Boston Scientific Scimed Inc. ,  Trustees of Boston University

Inventor： LYDECKER, Lauren S. ,  FREDRICKSON, Gerald ,  BERRY, Samantha ,  COOK, Katherine A. ,  GRINSTAFF, Mark

IPC: A61L24/00 ,  A61L24/04 ,  A61L26/00 ,  A61L31/06 ,  A61L31/14

CPC classification number: A61L24/0031 ,  A61L26/008 ,  A61L31/145 ,  A61L31/06 ,  A61L26/0019 ,  A61L24/046 ,  A61L2430/4020130101 ,  A61L2400/0620130101

公开(公告)号：EP3079731B1

公开(公告)日：2018-08-08

申请号：EP14828009.2

申请日：2014-12-10

Applicant: Ferrosan Medical Devices A/S

Inventor： LARSEN, Kristian

IPC: A61L24/00 ,  A61L24/10 ,  A61L26/00

CPC classification number: A61L26/0066 ,  A61L24/0036 ,  A61L24/104 ,  A61L26/0009 ,  A61L26/0019 ,  A61L26/0038 ,  A61L26/0047 ,  A61L26/0052 ,  A61L26/0085 ,  A61L2300/254 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2430/34

Abstract: Disclosed is a dry composition comprising one or more polyols, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste reconstitutes spontaneously upon addition of the liquid; hence no mechanical mixing is required for said paste to form. The composition may further comprise an extrusion enhancer, such as albumin. Also disclosed are methods of preparing said dry composition, a paste obtained from said dry composition and uses of said dry composition or paste for medical and surgical purposes.

公开(公告)号：EP3310842A1

公开(公告)日：2018-04-25

申请号：EP16730819.6

申请日：2016-06-17

Applicant: Gecko Biomedical

Inventor： PEREIRA, Maria ,  BRILLAUD, Elsa

IPC: C08G63/47 ,  A61L15/26 ,  A61L26/00 ,  C09J167/06

CPC classification number: C08G63/47 ,  A61L15/26 ,  A61L26/0019 ,  C09J167/06 ,  C08L67/04

Abstract: A composition with improved adhesive and sealant properties comprises a) a pre-polymer comprising a polymeric unit of the general formula (-A-B-)n, wherein A represents a substituted or un-substituted ester, B represents a substituted or un-substituted acid ester comprising at least two acid ester functionalities, and n represents an integer greater than 1; wherein the content of grafted anhydride in the composition is less than 0.05mol/mol of polyacid.

公开(公告)号：EP3280461A1

公开(公告)日：2018-02-14

申请号：EP16777115.3

申请日：2016-04-04

Applicant: 3M Innovative Properties Company

Inventor： LANGER-ANDERSON, Delony L. ,  GRIESGRABER, George W. ,  COLAK ATAN, Semra ,  PEREIRA, Junia M. ,  WLASCHIN, Katie F. ,  YOUNG, Alexi J. ,  ASMUS, Robert A. ,  KOHLER RIEDI, Petra L. ,  HAYS, David S. ,  RASMUSSEN, Jerald K. ,  SOLBERG, Michael J.

IPC: A61L24/06 ,  A61L26/00 ,  A61K31/275 ,  A61K9/70

CPC classification number: A61L26/0066 ,  A61K9/7015 ,  A61K31/275 ,  A61K47/34 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/043 ,  A61L24/06 ,  A61L26/00 ,  A61L26/0004 ,  A61L26/0019 ,  A61L26/0052 ,  A61L26/0061 ,  A61L26/0095 ,  A61L2300/404 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2430/34 ,  Y02A50/473 ,  C08L83/04

Abstract: Film forming gel compositions, useful in creating conformable and flexible gel bandages, can be formulate from a film forming polymer, a tackifier, and a volatile solvent. The film forming gels can also include antiseptics, cationic polymer coagulants, fillers, and other additives. The gel compositions form relatively thick films when dried on tissue, and can exhibit enhanced breathability to promote wound healing.

公开(公告)号：EP3228331A1

公开(公告)日：2017-10-11

申请号：EP15841194.2

申请日：2015-09-02

Applicant: Endoclot Plus (Suzhou) Co., Ltd.

Inventor： JI, Xin ,  XING, Cheng ,  ZHANG, Heng

IPC: A61L15/26 ,  A61L15/60 ,  A61L15/44

CPC classification number: A61L26/0019 ,  A61K9/14 ,  A61L15/26 ,  A61L15/44 ,  A61L15/46 ,  A61L24/0015 ,  A61L24/0026 ,  A61L24/043 ,  A61L24/046 ,  A61L26/0052 ,  A61L26/0061 ,  A61L26/0066 ,  A61L26/0076 ,  A61L2300/418 ,  A61L2300/60 ,  A61L2400/04 ,  A61P17/02 ,  C08L71/02

Abstract: Provided herein are a biocompatible hemostatic product and a tissue sealant, comprising polyethylene oxide particles with a viscosity-average molecular weight ranging from 100,000 to 7,000,000 Daltons, a particle size ranging from 0.5µm to 2000µm and a water absorbency capacity ranging from 1 to 500 times of its own weight. Also provided herein is a method for preparing biocompatible hemostatic product and tissue sealant and the use of the biocompatible hemostatic product and tissue sealant in hemostasis, preventing adhesion, avoiding infection, promoting tissue healing, and sealing wound of tissues and organs either on animal's body surface, or inside body's cavity.

Abstract translation: 本发明提供生物相容性止血产品和组织密封剂，其包含粘均分子量为100,000至7,000,000道尔顿，粒径为0.5μm至2000μm，吸水倍率为1至500倍的聚环氧乙烷颗粒 的重量。 本文还提供了一种用于制备生物相容性止血产品和组织密封剂的方法以及该生物相容性止血产品和组织密封剂在止血，防止粘连，避免感染，促进组织愈合以及密封组织和器官在动物身体表面上的伤口中的用途 ，或者在体腔内。

公开(公告)号：EP3169372A1

公开(公告)日：2017-05-24

申请号：EP15821310.8

申请日：2015-07-17

Applicant: The Regents of the University of California

Inventor： GRIFFIN, Donald R. ,  WEAVER, Westbrook ,  SEGURA, Tatiana ,  DI CARLO, Dino ,  SCUMPIA, Philip

IPC: A61L15/42 ,  A61L15/44 ,  A61L15/60

CPC classification number: A61L26/008 ,  A61L26/0019 ,  A61L26/0047 ,  A61L26/0066 ,  A61L26/0085 ,  A61L26/009 ,  A61L27/18 ,  A61L27/227 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2400/06 ,  A61L2430/00 ,  A61L2430/34 ,  C08L71/02

Abstract: A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.

Abstract translation: 用于某些应用（包括生物医学应用）的微孔凝胶系统包括含有多个包含生物可降解交联剂的微凝胶颗粒的水溶液。 在一些方面，微凝胶颗粒充当彼此退火以形成其中具有间隙空间的微凝胶颗粒的共价稳定支架的凝胶构建块。 在某些方面，微凝胶颗粒的退火发生在暴露于内源性存在或外源添加的退火剂之后。 在一些实施方案中，微凝胶颗粒的退火需要存在引发剂，例如暴露于光下。 在具体的实施方案中，可以控制凝胶构建块的化学和物理性质以允许下游控制所得到的组装支架。 在一个或多个实施方案中，细胞能够快速渗入组装好的支架的间隙空间。

公开(公告)号：EP3081236A1

公开(公告)日：2016-10-19

申请号：EP14870365.5

申请日：2014-12-12

Applicant: Utah-Inha DDS & Advanced Therapeutics Research Center

Inventor： LEE, Eunhye ,  MAENG, Jin Hee ,  KIM, Keun Su ,  LEE, Don Haeng ,  PARK, Young Hwan

IPC: A61L24/08 ,  A61L15/44 ,  A61L27/54 ,  A61L26/00

CPC classification number: A61L24/08 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/043 ,  A61L24/046 ,  A61L24/108 ,  A61L26/0019 ,  A61L26/0023 ,  A61L26/0047 ,  A61L26/0052 ,  A61L26/0066 ,  A61L26/008 ,  A61L26/009 ,  A61L27/18 ,  A61L27/20 ,  A61L27/227 ,  A61L27/26 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/418 ,  A61L2300/604 ,  A61L2400/04 ,  A61L2430/34 ,  C08L5/00 ,  C08L71/00

Abstract: The present invention provides a biodegradable medical adhesive or a sealant composition containing an oxidized glycosaminoglycan and a polyamine. The composition of the present invention exhibits improved effects in biodegradation, coating property, gelation time, hemostatic capacity, adhesive force, moisture absorptive capacity and the like, and thus can be applied to various medical uses in which a medical adhesive or sealant can be used, such as biotissue adhesion, filling, coating, adhesion prevention, wound covering, leakage prevention and hemostasis.

Abstract translation: 本发明提供一种可生物降解的医用粘合剂或含有氧化的糖胺聚糖和多胺的密封剂组合物。 本发明的组合物在生物降解，涂布性，凝胶化时间，止血能力，粘合力，吸湿能力等方面表现出改善的效果，因此可以应用于可以使用医用粘合剂或密封剂的各种医疗用途 ，如生物组织粘附，填充，涂层，防粘附，伤口覆盖，防漏和止血。

公开(公告)号：EP2925256A4

公开(公告)日：2016-08-17

申请号：EP14743314

申请日：2014-01-22

Applicant: PROLYNX LLC

Inventor： HENISE JEFFREY C ,  ASHLEY GARY W ,  SANTI DANIEL V

IPC: A61L24/00 ,  A61L24/04 ,  A61L24/06 ,  A61L24/10 ,  A61L26/00 ,  C09B11/24 ,  C09B57/02

CPC classification number: A61L26/0019 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/0036 ,  A61L24/0042 ,  A61L24/043 ,  A61L24/06 ,  A61L24/10 ,  A61L26/0066 ,  A61L26/008 ,  A61L26/0085 ,  A61L26/009 ,  A61L2300/216 ,  A61L2300/604 ,  C09B11/24 ,  C09B57/02

Abstract: The invention provides sealants wherein biodegradable hydrogels that do not otherwise comprise protein-reactive groups for binding to membranes or tissue are provided said groups optionally through a linker. The linker may be biodegradable and may be biodegradable by an elimination reaction. The invention also provides multilayer gels for drug delivery wherein a porous gel in contact with a tissue or organ to which the drug is to be delivered is protected by a microporous layer from the surrounding bodily fluid.

公开(公告)号：EP2437724B1

公开(公告)日：2015-09-30

申请号：EP10783928.4

申请日：2010-06-01

Applicant: Tyrx, Inc.

Inventor： BAHULEKAR, Raman ,  MOSES, Arikha ,  BUEVICH, Fatima ,  PULAPURA, Satish ,  MCJAMES, William C.

IPC: A61L26/00

CPC classification number: A61L26/0066 ,  A61L26/0019 ,  A61L26/009 ,  A61L2300/404 ,  A61L2300/602 ,  C08L77/12

公开(公告)号：EP2611413A4

公开(公告)日：2015-04-15

申请号：EP11822576

申请日：2011-08-31

Applicant: LIVING PROOF INC

Inventor： YU BETTY ,  LOMAKIN JOSEPH ,  KANG SOO-YOUNG ,  ADAMS BENJAMIN W

IPC: A61K8/89 ,  A61K8/34 ,  A61K8/891 ,  A61K8/895 ,  A61K31/74 ,  A61K31/795 ,  A61P17/00 ,  A61Q1/02 ,  A61Q1/14 ,  A61Q19/00 ,  A61Q19/08

CPC classification number: A61K31/765 ,  A61K8/0204 ,  A61K8/19 ,  A61K8/25 ,  A61K8/29 ,  A61K8/345 ,  A61K8/585 ,  A61K8/891 ,  A61K8/894 ,  A61K8/895 ,  A61K2800/412 ,  A61K2800/43 ,  A61K2800/58 ,  A61K2800/5922 ,  A61K2800/884 ,  A61K2800/95 ,  A61L26/0019 ,  A61L26/0095 ,  A61Q1/02 ,  A61Q1/14 ,  A61Q19/00 ,  A61Q19/06 ,  A61Q19/08 ,  C08L83/04

Abstract: Provided are body corrective cosmetic formulations and methods of use thereof.