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    Method for making composite PMC polymeric materials based on TFE polymers and copolymers having a controlled porosity and adjustable properties
    7.
    发明公开
    Method for making composite PMC polymeric materials based on TFE polymers and copolymers having a controlled porosity and adjustable properties 审中-公开
    一种用于生产基于TFE的聚合物复合PMC聚合物材料和共聚物具有受控孔隙率和可定制性过程

    公开(公告)号：EP2725056A1

    公开(公告)日：2014-04-30

    申请号：EP12190161.5

    申请日：2012-10-26

    申请人： F.M.I. S.P.A.

    发明人： Rossi, Franco

    IPC分类号： C08J9/00 ,  C08J9/26 ,  C08J9/35

    CPC分类号： C08J9/08 ,  C08J9/0014 ,  C08J9/0066 ,  C08J9/10 ,  C08J9/26 ,  C08J2201/042 ,  C08J2201/044 ,  C08J2203/02 ,  C08J2203/04 ,  C08J2205/044 ,  C08J2327/18

    摘要： A method for making composite PMC polymeric materials, based on TFE polymers and/or copolymers, having a controlled porosity and modularly adjustable properties, said method comprising the steps of: a) mixing a TFE polymer or copolymer with one or more organic, inorganic substances in a solid or liquid form, to adjust the chemical, physical and mechanical properties of the composite material; b) adding to the mixture chemical organic and inorganic composites and complex mixtures thereof, said substances being adapted to sublimate or quickly evaporate or transform into a gas by a thermal processing in a temperature range from 30° to 380°C, B Composites, said "B Composites" being absent in the end product after sintering; c) processing said mixture to form articles; d) thermally processing, under vacuum, said articles to form a controlled porosity; and e) thermally sintering said controlled porosity articles of said step d).

    摘要翻译： 一种用于制造复合PMC聚合物材料，基于TFE的聚合物和/或共聚物，具有受控的孔隙率和模块化可调特性的方法，所述方法包括如下步骤：a）将TFE聚合物或共聚物与一种或多种有机的，无机物质 在固体或液体形式，以调节复合材料的化学，物理和机械性能; b）加入到该混合物中化学的有机和无机复合材料和复杂混合物，所述适于物质升华或快速蒸发或从30℃的温度范围内变成气体通过热处理，以380℃，B复合材料，说 “B复合材料”烧结后是在最终产物中不存在; c）中处理所述的混合物以形成制品; D）热加工，在真空下，所述制品以形成可控孔隙率; 和e）热烧结所述步骤d的所述可控孔隙度的文章）。

    Polyhydroxyalkanoate compositions having controlled degradation rates
    9.
    发明公开
    Polyhydroxyalkanoate compositions having controlled degradation rates 有权
    具有可控降解速率的聚羟基链烷酸酯组合物

    公开(公告)号：EP2196484A1

    公开(公告)日：2010-06-16

    申请号：EP10075046.2

    申请日：1998-12-22

    申请人： Metalbolix Inc.

    发明人： Martin, David P ,  Skraly, Frank A ,  Williams, Simon F

    IPC分类号： C08G63/06 ,  C08G63/91 ,  C08K3/00 ,  C08K5/00 ,  C08J9/26 ,  C08J9/28 ,  C08L67/04 ,  C12P7/62 ,  A61K47/34 ,  A61L17/00 ,  A61L27/00 ,  A61L31/00

    CPC分类号： A61L31/06 ,  A61K9/1647 ,  A61K9/204 ,  A61K47/34 ,  A61K47/593 ,  A61L15/26 ,  A61L17/12 ,  A61L24/0042 ,  A61L26/0019 ,  A61L26/009 ,  A61L27/18 ,  A61L27/34 ,  A61L27/58 ,  A61L29/06 ,  A61L31/148 ,  C08G63/06 ,  C08G63/60 ,  C08G63/64 ,  C08G63/664 ,  C08G63/6852 ,  C08G63/6882 ,  C08J9/26 ,  C08J2201/044 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C08L67/04 ,  C08L101/00 ,  C12P7/625 ,  C08L2666/02

    摘要： The present application provides a biocompatible medical implant comprising poly(4-hydroxybutyrate) homopolymer. Optionally, the implant is sterile. The implant may, for example, be selected from guided tissue regeneration devices, tissue engineering devices, tissue engineering scaffolds, foams, coatings, meshes, microparticles, resorbable wound closure materials such as suturing and stapling materials, controlled release devices, drug delivery devices, cell encapsulation devices, targeted delivery devices, devices with biocompatible coatings, orthopedic devices, prosthetics, bone cements (including adhesives and/or structural fillers), diagnostic devices, rods, bone screws, pins, surgical sutures, stents, patches (such as hernial patches and pericardial patches), devices with vascular applications, and tubes suitable for the passage of bodily fluids. The invention also provides a method for preparing a biocompatible polyhydroxyalkanoate that has a controlled degradation rate of less than one year under physiological conditions, and optionally processing thus prepared polyhydroxyalkanoate into a medical device. The biocompatible polyhydroxyalkanoate used in the method may, for example, be produced by a process selected from the group consisting of fermentation, enzymatic synthesis, chemical synthesis, melt processing, reactive blending, and recombinant techniques. The biocompatible polyhydroxyalkanoate used in the method may, for example, be derived by fermentation (a) using a co-feed, and/or (b) by a fermentation process that uses transgenic bacteria.

    摘要翻译： 本申请提供了包含聚（4-羟基丁酸酯）均聚物的生物相容性医学植入物。 可选地，植入物是无菌的。 植入物可以例如选自引导的组织再生装置，组织工程装置，组织工程支架，泡沫，涂层，网状物，微粒，可再吸收的伤口闭合材料例如缝合和缝合材料，控释装置，药物输送装置， 细胞封装装置，靶向输送装置，具有生物相容性涂层的装置，矫形装置，假体，骨接合剂（包括粘合剂和/或结构填充物），诊断装置，棒，骨螺钉，针，外科缝合线，支架，贴片 贴片和心包贴片），具有血管应用的装置和适于体液通过的管。 本发明还提供了一种用于制备在生理条件下具有小于一年的受控降解速率的生物相容性聚羟基链烷酸酯的方法，并且任选地将如此制备的聚羟基链烷酸酯加工成医疗装置。 用于该方法中的生物相容性聚羟基链烷酸酯可以例如通过选自发酵，酶促合成，化学合成，熔融加工，反应性共混和重组技术的方法生产。 用于该方法中的生物相容性聚羟基链烷酸酯可以例如通过发酵（a）使用共同进料，和/或（b）通过使用转基因细菌的发酵过程来获得。