公开(公告)号：EP2627178B1

公开(公告)日：2018-05-02

申请号：EP11833150.3

申请日：2011-10-06

申请人： Merck Sharp & Dohme Corp.

发明人： PALANI, Anandan ,  ASLANIAN, Robert, G. ,  BOYCE, Christopher, W. ,  MAZZOLA, Robert, D.,Jr. ,  MCKITTRICK, Brian, A. ,  MCCORMICK, Kevin, D. ,  QIN, Jun ,  TANG, Haiqun ,  XIAO, Dong ,  YU, Younong ,  CALDWELL, John, P. ,  KELLEY, Elizabeth, Helen ,  ZHANG, Hongjun ,  SILIPHAIVANH, Phieng ,  MACCOSS, Rachel, N. ,  METHOT, Joey, L. ,  GAUUAN, Jolicia Polivina ,  JIANG, Qin ,  LEYHANE, Andrew, J. ,  BIJU, Purakkattle Johny ,  DONG, Li ,  HUANG, Xianhai ,  SHAO, Ning ,  ZHOU, Wei ,  DHONDI, Pawan, K. ,  RAO, Ashwin, U.

IPC分类号： A01N43/54 ,  C07D239/42 ,  C07D401/04

CPC分类号： C07D239/91 ,  A61K31/517 ,  A61K31/5395 ,  A61K31/55 ,  A61K45/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/10 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/10 ,  C07D471/04 ,  C07D498/10

摘要： This application provides for compounds of the formula Formula I or a pharmaceutically acceptable salt thereof, wherein the individual variables are defined herein, as well as processes to prepare these compounds, pharmaceutical compositions comprising the same and their use in treating disease state associated with the CRTH2 receptor.

公开(公告)号：EP2627178A1

公开(公告)日：2013-08-21

申请号：EP11833150.3

申请日：2011-10-06

申请人： Merck Sharp & Dohme Corp.

发明人： PALANI, Anandan ,  ASLANIAN, Robert, G. ,  BOYCE, Christopher, W. ,  MAZZOLA, Robert, D.,Jr. ,  MCKITTRICK, Brian, A. ,  MCCORMICK, Kevin, D. ,  QIN, Jun ,  TANG, Haiqun ,  XIAO, Dong ,  YU, Younong ,  CALDWELL, John, P. ,  KELLEY, Elizabeth, Helen ,  ZHANG, Hongjun ,  SILIPHAIVANH, Phieng ,  MACCOSS, Rachel, N. ,  METHOT, Joey, L. ,  GAUUAN, Jolicia, Polivina ,  JIANG, Qin ,  LEYHANE, Andrew, J. ,  BIJU, Purakkattle Johny ,  DONG, Li ,  HUANG, Xianhai ,  SHAO, Ning ,  ZHOU, Wei ,  DHONDI, Pawan, K. ,  RAO, Ashwin, U.

IPC分类号： A01N43/54 ,  C07D239/42 ,  C07D401/04

CPC分类号： C07D239/91 ,  A61K31/517 ,  A61K31/5395 ,  A61K31/55 ,  A61K45/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/10 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/10 ,  C07D471/04 ,  C07D498/10

摘要： This application provides for compounds of the formula Formula I or a pharmaceutically acceptable salt thereof, wherein the individual variables are defined herein, as well as processes to prepare these compounds, pharmaceutical compositions comprising the same and their use in treating disease state associated with the CRTH
2 receptor.