公开(公告)号：EP2501232A1

公开(公告)日：2012-09-26

申请号：EP10830771.1

申请日：2010-11-12

申请人： Merck Sharp & Dohme Corp.

发明人： RAO, Ashwin, U. ,  PALANI, Anandan ,  ASLANIAN, Robert, G.

IPC分类号： A01N43/52 ,  A61K31/415

CPC分类号： C07D471/04 ,  A61K31/4025

摘要： The present invention relates to novel imidazole compounds, pharmaceutical compositions comprising the imidazole compounds and the use of these compounds for treating or preventing allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below:

公开(公告)号：EP2922539B1

公开(公告)日：2020-01-15

申请号：EP13843517.7

申请日：2013-09-26

申请人： Merck Sharp & Dohme Corp.

发明人： HUANG, Xianhai ,  PALANI, Anandan ,  RAO, Ashwin, U. ,  ZHANG, Hongjun ,  ZHOU, Wei

IPC分类号： A61K31/4245 ,  A61K31/472 ,  C07D401/12 ,  A61P11/06 ,  A61K31/4725

公开(公告)号：EP2627178B1

公开(公告)日：2018-05-02

申请号：EP11833150.3

申请日：2011-10-06

申请人： Merck Sharp & Dohme Corp.

发明人： PALANI, Anandan ,  ASLANIAN, Robert, G. ,  BOYCE, Christopher, W. ,  MAZZOLA, Robert, D.,Jr. ,  MCKITTRICK, Brian, A. ,  MCCORMICK, Kevin, D. ,  QIN, Jun ,  TANG, Haiqun ,  XIAO, Dong ,  YU, Younong ,  CALDWELL, John, P. ,  KELLEY, Elizabeth, Helen ,  ZHANG, Hongjun ,  SILIPHAIVANH, Phieng ,  MACCOSS, Rachel, N. ,  METHOT, Joey, L. ,  GAUUAN, Jolicia Polivina ,  JIANG, Qin ,  LEYHANE, Andrew, J. ,  BIJU, Purakkattle Johny ,  DONG, Li ,  HUANG, Xianhai ,  SHAO, Ning ,  ZHOU, Wei ,  DHONDI, Pawan, K. ,  RAO, Ashwin, U.

IPC分类号： A01N43/54 ,  C07D239/42 ,  C07D401/04

CPC分类号： C07D239/91 ,  A61K31/517 ,  A61K31/5395 ,  A61K31/55 ,  A61K45/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/10 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/10 ,  C07D471/04 ,  C07D498/10

摘要： This application provides for compounds of the formula Formula I or a pharmaceutically acceptable salt thereof, wherein the individual variables are defined herein, as well as processes to prepare these compounds, pharmaceutical compositions comprising the same and their use in treating disease state associated with the CRTH2 receptor.

公开(公告)号：EP1885726B1

公开(公告)日：2016-12-14

申请号：EP06759539.7

申请日：2006-05-11

申请人： Merck Sharp & Dohme Corp.

发明人： PALANI, Anandan ,  SU, Jing ,  XIAO, Dong ,  HUANG, Xianhai ,  RAO, Ashwin, U. ,  CHEN, Xiao ,  TANG, Haiqun ,  QIN, Jun ,  HUANG, Ying ,  ASLANIAN, Robert, G. ,  MCKITTRICK, Brian

IPC分类号： C07D491/04

CPC分类号： C07D471/04 ,  C07D491/04 ,  C07D491/052

公开(公告)号：EP2627178A1

公开(公告)日：2013-08-21

申请号：EP11833150.3

申请日：2011-10-06

申请人： Merck Sharp & Dohme Corp.

发明人： PALANI, Anandan ,  ASLANIAN, Robert, G. ,  BOYCE, Christopher, W. ,  MAZZOLA, Robert, D.,Jr. ,  MCKITTRICK, Brian, A. ,  MCCORMICK, Kevin, D. ,  QIN, Jun ,  TANG, Haiqun ,  XIAO, Dong ,  YU, Younong ,  CALDWELL, John, P. ,  KELLEY, Elizabeth, Helen ,  ZHANG, Hongjun ,  SILIPHAIVANH, Phieng ,  MACCOSS, Rachel, N. ,  METHOT, Joey, L. ,  GAUUAN, Jolicia, Polivina ,  JIANG, Qin ,  LEYHANE, Andrew, J. ,  BIJU, Purakkattle Johny ,  DONG, Li ,  HUANG, Xianhai ,  SHAO, Ning ,  ZHOU, Wei ,  DHONDI, Pawan, K. ,  RAO, Ashwin, U.

IPC分类号： A01N43/54 ,  C07D239/42 ,  C07D401/04

CPC分类号： C07D239/91 ,  A61K31/517 ,  A61K31/5395 ,  A61K31/55 ,  A61K45/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/10 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/10 ,  C07D471/04 ,  C07D498/10

摘要： This application provides for compounds of the formula Formula I or a pharmaceutically acceptable salt thereof, wherein the individual variables are defined herein, as well as processes to prepare these compounds, pharmaceutical compositions comprising the same and their use in treating disease state associated with the CRTH
2 receptor.

公开(公告)号：EP2922539A1

公开(公告)日：2015-09-30

申请号：EP13843517.7

申请日：2013-09-26

申请人： Merck Sharp & Dohme Corp.

发明人： HUANG, Xianhai ,  PALANI, Anandan ,  RAO, Ashwin, U. ,  ZHANG, Hongjun ,  ZHOU, Wei

IPC分类号： A61K31/4245 ,  A61K31/47 ,  A01N43/42

CPC分类号： C07D217/24 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/496 ,  A61K45/06 ,  C07D401/06 ,  C07D401/12 ,  C07D413/04 ,  C07D413/14 ,  A61K2300/00

摘要： The invention provides certain substituted isoquinolines of the Formula (I), and their pharmaceutically acceptable salts and esters. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.