公开(公告)号：EP1173562A2

公开(公告)日：2002-01-23

申请号：EP00954830.6

申请日：2000-05-03

申请人： Methylgene, Inc.

发明人： MACLEOD, Alan, R. ,  LI, Zuomei ,  BESTERMAN, Jeffrey, M.

IPC分类号： C12N15/11 ,  A61K31/7125 ,  C07H21/00 ,  C12Q1/44 ,  G01N33/50 ,  C12Q1/68

CPC分类号： C12N15/1137 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/345 ,  C12N2310/346 ,  C12N2310/3521

摘要： The invention relates to the inhibition of histone deacetylase expression and enzymatic activity and, in particular, to the inhibition of a specific histone deacetylase. The invention also relates to compositions comprising antisense oligonucleotides and methods of using the same to inhibit a histone deacetylase. Also disclosed are methods for identifying a histone deacetylase involved in induction of cell proliferation, and methods for identifying compounds that interact with and reduce the enzymatic activity of such a histone deacetylase.

公开(公告)号：EP1438404A2

公开(公告)日：2004-07-21

申请号：EP01274226.8

申请日：2001-03-26

申请人： Methylgene, Inc.

发明人： LI, Zuomei ,  BONFILS, Claire ,  BESTERMAN, Jeffrey

IPC分类号： C12N15/11 ,  A61K31/7125 ,  C07H21/04 ,  C12Q1/44

CPC分类号： C12N15/1137 ,  A61K31/18 ,  A61K31/4035 ,  A61K31/4418 ,  A61K31/711 ,  A61K38/00 ,  C07C237/20 ,  C07C311/21 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3521

摘要： This invention relates to the inhibition of histone deacetylase expression and enzymatic activity. The invention provides methods and reagents for inhibiting specific histone deacetylase (HDAC) isoforms by inhibiting expression at the nucleic acid level or enzymatic activity at the protein level.