公开(公告)号：EP2356105A1

公开(公告)日：2011-08-17

申请号：EP09744410.3

申请日：2009-11-03

申请人： N.V. Organon

发明人： GROVE, Simon, James, Anthony ,  MISTRY, Ashvinkumar, Dhirubhai ,  PALIN, Ronald ,  MACLEAN, John, Kinnaird, Ferguson

IPC分类号： C07D401/10 ,  A61K31/4439 ,  A61P25/02

CPC分类号： C07D401/10

摘要： The invention relates to (pyrrolidin-2-yl)phenyl derivatives having the general Formula (I), wherein R
1 is (C
1-4 )alkyl, halo(C
1-4 )alkyl, (C
1-4 )alkyloxy, or halo(C
1-4 )alkyloxy; R
2 is H, (C
1-4 )alkyl, halo(C
1-4 )alkyl, (C
1-4 )alkyloxy, halo(C
1-4 )alkyloxy or halogen; R
3 is H, (C
1-4 )alkyl or halo(C
1-4 )alkyl; R
4 is H, (C
1-4 )alkyl or halo(C
1-4 )alkyl; R
5 is H, (C
1-4 )alkyl or halo(C
1-4 )alkyl; or R4 and R5, when bonded to the same carbon atom, can together with the carbon atom form a spiro(C
3-6 )cycloalkyl group, optionally substituted with halogen; R
6 is H, (C
1-4 )alkyl, halo(C
1-4 )alkyl, (C
1-4 )alkyloxy, halo(C
1-4 )alkyloxy or halogen; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of these (pyrrolidin-2-yl)phenyl derivatives for the treatment of pain, such as neuropathic pain or inflammatory pain.

公开(公告)号：EP2041124A1

公开(公告)日：2009-04-01

申请号：EP07801415.6

申请日：2007-07-02

申请人： N.V. Organon

发明人： GILLEN, Kevin, James ,  JAMIESON, Craig ,  MACLEAN, John, Kinnaird, Ferguson ,  MOIR, Elizabeth, Margaret ,  RANKOVIC, Zoran

IPC分类号： C07D409/12 ,  C07D409/14 ,  A61K31/497 ,  A61P25/28 ,  C07D417/14 ,  C07D495/04

CPC分类号： C07D409/12 ,  C07D409/14 ,  C07D471/04 ,  C07D495/04

摘要： The present invention relates to a heterocyclic derivative according to Formula (I) wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising said heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of psychiatric diseases where an enhancement of synaptic responses mediated by AMPA receptors is required, including schizophrenia, depression and Alzheimer's disease.

摘要翻译： 本发明涉及根据式（I）的杂环衍生物或其药学上可接受的盐或溶剂化物，其中变量如说明书中所定义。 本发明还涉及包含所述杂环衍生物的药物组合物及其在治疗中的用途，例如治疗或预防精神疾病，其中需要增强由AMPA受体介导的突触反应，包括精神分裂症，抑郁症和阿尔茨海默氏病 。

公开(公告)号：EP2297110A1

公开(公告)日：2011-03-23

申请号：EP09757548.4

申请日：2009-06-03

申请人： N.V. Organon

发明人： GILLESPIE, Jonathan ,  JAMIESON, Craig ,  MACLEAN, John, Kinnaird, Ferguson ,  MOIR, Elizabeth, Margaret ,  RANKOVIC, Zoran

IPC分类号： C07D231/12 ,  C07D231/14 ,  C07D231/18 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  A61K31/415 ,  A61P25/00

CPC分类号： C07D231/14 ,  C07D231/12 ,  C07D231/18 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04

摘要： The present invention relates to a heterocyclic derivative according to formula (I); wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising said heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of psychiatric diseases where an enhancement of synaptic responses mediated by AMPA receptors is required, including schizophrenia, depression and Alzheimer's disease.