摘要:
In one aspect, the invention relates to compounds having the formula I: where R1-R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
摘要:
The present invention provides a compound of formula (I) or its salts or pharmaceutically acceptable derivatives wherein R1, R2, R3, X1, and A are defined herein. The compounds are useful as potassium ion channel inhibitors.
摘要:
wherein R 1 and R 2 each independently represents a halogen atom, a C1-C4 alkyl group, or a C1-C4 haloalkyl group; m and n each independently represents an integer of 0 to 4; R 3 and R 4 each represents a hydrogen atom; Y represents formula: -OC(=X)ZR 5 or -SC (=X) ZR 5 ; R 5 represents a C1-C3 alkyl group optionally having one or more halogen atoms; Z represents a sulfur atom, NR 8 , or a direct bond; R 8 represents a C1-C3 alkyl group or a hydrogen atom; Q represents a pyrazolyl group optionally having a substituent; and W and X each independently represents an oxygen atom or a sulfur atom, has excellent control activity against pests.
摘要翻译:其中R 1和R 2各自独立地表示卤素原子,C 1 -C 4烷基或C 1 -C 4卤代烷基; m和n各自独立地表示0至4的整数; R 3和R 4各自表示氢原子; Y表示式-OC(= X)ZR 5或-SC(= X)ZR 5; R 5表示任选具有一个或多个卤素原子的C1-C3烷基; Z代表硫原子,NR 8或直接键; R 8表示C 1 -C 3烷基或氢原子; Q表示任选具有取代基的吡唑基; W和X各自独立地表示氧原子或硫原子,对害虫具有优异的防治活性。
摘要:
The present invention relates to naphthyl sulfonamide phenyl derivatives of the formula I
in which R1, R2, R3, R4, R5, R6, R7, R8, R10, A, X, L, q, i and R50 are defined as indicated below. The naphthyl sulfonamide phenyl derivatives I are KEAP-1 modulators and useful for the prevention and/or treatment of diabetes, obesity, dyslipidemia and related disorders. The invention furthermore relates to the use of naphthyl sulfonamide phenyl derivatives of the formula I as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
摘要:
An object of the present invention is to provide a novel endoparasite control agent as a parasiticide, an antiprotozoal or the like. Provided is an endoparasite control agent comprising a carboxamide derivative represented by the general formula (I): or a salt thereof as an active ingredient.
摘要:
The invention is concerned with the compounds of formula (I): and salts thereof, wherein X, Y, Z, R1, R2, R3, R3′, R4, R5 and R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of Formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
摘要:
An object of the present invention is to provide a novel endoparasite control agent as a parasiticide, an antiprotozoal or the like. Provided is an endoparasite control agent comprising a carboxamide derivative represented by the general formula (I):