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    NOVEL 1,4-DIAZA-BICYCLOÝ3.2.2¨NONYL PYRIMIDINYL DERIVATIVES AND THEIR MEDICAL USE
    2.
    发明公开
    NOVEL 1,4-DIAZA-BICYCLOÝ3.2.2¨NONYL PYRIMIDINYL DERIVATIVES AND THEIR MEDICAL USE 审中-公开
    新型1,4-二氮杂双环[3.2.2]壬基嘧啶衍生物及其医疗用途

    公开(公告)号：EP2041134A1

    公开(公告)日：2009-04-01

    申请号：EP07729592.1

    申请日：2007-05-29

    申请人： NeuroSearch A/S

    发明人： PETERS, Dan ,  OLSEN, Gunnar, M. ,  NIELSEN, Elsebet, Østergaard ,  TIMMERMANN, Daniel, B. ,  LOECHEL, Steven, Charles ,  CHRISTENSEN, Jeppe, Kejser ,  MIKKELSEN, Jens, Damsgaard ,  HANSEN, Henrik, Björk ,  REDROBE, John, Paul ,  DYHRING, Tino

    IPC分类号： C07D471/08 ,  A61K31/551 ,  A61P25/00

    CPC分类号： C07D471/08

    摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基嘧啶基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体上的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于它们的药理学特征，本发明的化合物可用于疾病或病症等不同的那些涉及到中枢神经系统（CNS），外周神经系统（PNS）的疾病或相关病症的胆碱能系统的治疗有用 平滑肌收缩，内分泌疾病或病症，与神经变性有关的疾病或病症，与炎症相关的疾病或病症，由化学物质滥用终止引起的疼痛和戒断症状。

    NOVEL DIPHENYL 1,2,3-TRIAZOLE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
    5.
    发明公开
    NOVEL DIPHENYL 1,2,3-TRIAZOLE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS 审中-公开
    NEW AS调节剂烟碱乙酰胆碱受体的1,2,3-三唑衍生物SUITABLE

    公开(公告)号：EP2313378A1

    公开(公告)日：2011-04-27

    申请号：EP09781390.1

    申请日：2009-08-03

    申请人： NeuroSearch A/S

    发明人： NARDI, Antonio ,  CHRISTENSEN, Jeppe, Kejser ,  PETERS, Dan

    IPC分类号： C07D249/06 ,  A61P25/00 ,  A61P29/00 ,  A61K31/4192

    CPC分类号： C07D249/06

    摘要： This invention relates to novel diphenyl 1,2,3-triazole derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    BENZISOXAZOLE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS FOR THE TREATMENT OF E.G. RESPIRATORY DISEASES, EPILEPSY AND CONVULSIONS
    6.
    发明公开
    BENZISOXAZOLE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS FOR THE TREATMENT OF E.G. RESPIRATORY DISEASES, EPILEPSY AND CONVULSIONS 审中-公开
    BENZISOXAZOLDERIVATE作为钾通道调节剂用于治疗例如 呼吸系统疾病，癫痫和痉挛

    公开(公告)号：EP2152679A1

    公开(公告)日：2010-02-17

    申请号：EP08759907.2

    申请日：2008-05-22

    申请人： NeuroSearch A/S

    发明人： NARDI, Antonio ,  MATHIESEN, Claus ,  CHRISTENSEN, Jeppe, Kejser

    IPC分类号： C07D261/20 ,  A61K31/42 ,  A61P25/08 ,  A61P11/06

    CPC分类号： C07D261/20

    摘要： This invention relates to novel benzisoxazole derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels e.g. a respiratory disease, epilepsy or convulsions. X represents a subsituent selected from the group consisting of CO-NR'R'', CO-O-R', CO-NH-S, CO-NH-SO2R''', CO-NH-C=N, SO2-NR'R'', 2,3-dihydro-1-H-tetrazol-5-yl and [1, 2, 4]oxadiazolidin-5-one; wherein R' and R'', independently of each other, represent hydrogen or alkyl or phenyl; and R''' represents alkyl, cycloalkyl, haloalkyl or phenyl, which phenyl may optionally be substituted one or more times with substituents selected from halo, trifluoromethyl, trifluoromethoxy, cyano and nitro.

    DIAZABICYCLOALKANE DERIVATIVES AND THEIR MEDICAL USE
    10.
    发明授权
    DIAZABICYCLOALKANE DERIVATIVES AND THEIR MEDICAL USE 有权
    二氮杂衍生物及其医药用途

    公开(公告)号：EP1987033B1

    公开(公告)日：2010-08-25

    申请号：EP07712214.1

    申请日：2007-02-13

    申请人： NeuroSearch A/S

    发明人： PETERS, Dan ,  TIMMERMANN, Daniel, B. ,  OLSEN, Gunnar, M. ,  NIELSEN, Elsebet, Østergaard ,  CHRISTENSEN, Jeppe, Kejser ,  DYHRING, Tino

    IPC分类号： C07D471/08 ,  A61K31/4995 ,  A61P25/28

    CPC分类号： C07D471/08

    摘要： This invention relates to novel diaza-bicyclo-alkane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.