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1.发明公开
公开(公告)号：EP2228434A4
公开(公告)日：2013-01-23
申请号：EP08857879
申请日：2008-12-05
CPC分类号： C12N5/0647 , A61K2035/124 , C07D231/12 , C07D333/22 , C07D409/12 , C07D409/14 , C07D417/14 , C12N2501/125 , C12N2501/145 , C12N2501/999
摘要： An object of the present invention is to expand CD34 + cells ex vivo efficiently in a short term using a biologically safe and inexpensively obtainable low molecular weight compound. A still another object of the present invention is to provide an expansion agent for CD34 + cells useful for treatment of various hematopoietic disorders caused by dysfunctional hematopoietic stem cells and/or hematopoietic progenitor cells. A method for expanding CD34 + cells, which comprises culturing CD34 + cells ex vivo in the presence of a compound represented by the formula (I) (wherein A, B, L 1 , L 2 , L 3 , L 4 , R 1 , R 2 , R 3 , X and Y are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound, or a solvate thereof.
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2.发明公开METHOD FOR AMPLIFICATION OF HEMATOPOIETIC STEM CELL USING HETEROCYCLIC COMPOUND 审中-公开含杂环化合物的造血干细胞扩增方法
公开(公告)号：EP2228435A4
公开(公告)日：2013-01-23
申请号：EP08858273
申请日：2008-12-05
CPC分类号： C12N5/0647 , A61K2035/124 , C07D231/12 , C07D333/22 , C07D409/12 , C07D409/14 , C07D417/14 , C12N2501/125 , C12N2501/145 , C12N2501/999
摘要： An object of the present invention is to expand CD34 + cells ex vivo efficiently in a short term using a biologically safe and inexpensively obtainable low molecular weight compound. A still another object of the present invention is to provide an expansion agent for CD34 + cells useful for treatment of various hematopoietic disorders caused by dysfunctional hematopoietic stem cells and/or hematopoietic progenitor cells. A method for expanding CD34 + cells, which comprises culturing CD34 + cells ex vivo in the presence of a compound represented by the formula (I) (wherein A, B, L 1 , L 2 , L 3 , L 4 , R 1 , R 2 , R 3 , X and Y are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.
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3.发明公开METHOD FOR AMPLIFICATION OF HEMATOPOIETIC STEM CELL USING HETEROCYCLIC COMPOUND 审中-公开用于扩增造血干细胞方法的杂环化合物的方法
公开(公告)号：EP2233561A4
公开(公告)日：2013-01-16
申请号：EP08856980
申请日：2008-12-05
CPC分类号： C12N5/0647 , A61K35/12 , C12N2501/125 , C12N2501/145 , C12N2501/999
摘要： An object of the present invention is to expand CD34 + cells ex vivo efficiently in a short term using a biologically safe and inexpensively obtainable low molecular weight compound. A still another object of the present invention is to provide an expansion agent for CD34 + cells useful for treatment of various hematopoietic disorders caused by dysfunctional hematopoietic stem cells and/or hematopoietic progenitor cells. A method for expanding CD34 + cells, which comprises culturing CD34 + cells ex vivo in the presence of a compound represented by the formula (I) (wherein A, B, L 1 , L 2 , L 3 , L 4 , R 1 , R 2 , R 3 , X and Y are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 本发明的目的是扩大的CD34 +细胞体外有效地使用生物安全且廉价地获得的低分子量化合物短期。 本发明的无声anOtherObject是提供扩张剂用于治疗由不正常的造血干细胞和/或造血祖细胞引起的各种造血病症CD34 +细胞。 一种用于扩展CD34 +细胞的方法，该方法包括培养的CD34 +细胞体外（在化合物的由式（I）表示的存在其中A，B，L 1，L 2，L 3，L 4，R 1， R 2，R 3，X和Y在说明书中定义），该化合物或其溶剂化物的互变异构体或药学上可接受的盐。
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