公开(公告)号：EP2768917B1

公开(公告)日：2018-12-05

申请号：EP12842316.7

申请日：2012-10-18

申请人： Sirrus, Inc.

发明人： MALOFSKY, Bernard, Miles ,  MALOFSKY, Adam, Gregg ,  DEY, Tanmoy ,  HINES, Larry ,  ELLISON, Matthew, Mcbrayer

IPC分类号： C07C69/74 ,  C09J133/06 ,  C08F222/10

CPC分类号： C08F20/28 ,  C07C45/75 ,  C07C49/794 ,  C07C49/796 ,  C07C49/798 ,  C07C49/80 ,  C07C67/03 ,  C07C67/30 ,  C07C69/604 ,  C07C69/738 ,  C07D307/46 ,  C07D307/54 ,  C07D333/22 ,  C07D333/24 ,  C08F20/14 ,  C08F20/30 ,  C08F20/38 ,  C08F20/68 ,  C08F22/20 ,  C08F24/00 ,  C08F28/06 ,  C08F116/36 ,  C08F128/06 ,  C08F222/1006 ,  C08F222/14 ,  C08K3/013 ,  C08K5/0008 ,  C08L21/00 ,  C08L33/14 ,  C08L33/16 ,  C08L35/02 ,  C09D4/00 ,  C09D129/12 ,  C09D133/14 ,  C09D133/16 ,  C09D135/02 ,  C09D141/00 ,  C09J133/06 ,  C09J133/14 ,  C09J133/16 ,  C09J135/02 ,  Y02P20/127

摘要： The present invention provides methylene beta-ketoester monomers, methods for producing the same, and compositions and products formed therefrom. In the method for producing the methylene beta-ketoesters of the invention, a beta-ketoester is reacted with a source of formaldehyde in a modified Knoevenagel reaction optionally in the presence of an acidic or basic catalyst, and optionally in the presence of an acidic or non-acidic solvent, to form reaction complex. The reaction complex may be an oligomeric complex. The reaction complex is subjected to further processing, which may be vaporization by contact with an energy transfer means in order to isolate the beta-ketoester monomer. The present invention further compositions and products formed from methylene beta-ketoester monomers of the invention, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).

公开(公告)号：EP2758414B1

公开(公告)日：2018-11-21

申请号：EP12775359.8

申请日：2012-09-20

申请人： Dow Silicones Corporation

发明人： BRANDSTADT, Kurt ,  COOK, Simon ,  NGUYEN, Binh, Thanh ,  SURGENOR, Avril ,  TAYLOR, Richard ,  TZOU, Ming-shin ,  OLSEN, Matthew ,  DASH, Aswini

IPC分类号： C07F15/00

CPC分类号： B01J31/2295 ,  B01J31/0272 ,  B01J31/22 ,  B01J31/24 ,  B01J31/2414 ,  B01J31/2433 ,  B01J37/00 ,  B01J2231/323 ,  B01J2531/16 ,  B01J2531/17 ,  B01J2531/46 ,  B01J2531/49 ,  B01J2531/56 ,  B01J2531/64 ,  B01J2531/74 ,  B01J2531/821 ,  B01J2531/827 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2531/847 ,  C07C209/66 ,  C07C213/08 ,  C07C217/92 ,  C07D213/32 ,  C07D213/38 ,  C07D213/53 ,  C07D215/12 ,  C07D271/06 ,  C07D295/135 ,  C07D307/52 ,  C07D333/22 ,  C07D413/10 ,  C07D413/14 ,  C07F1/00 ,  C07F1/005 ,  C07F1/08 ,  C07F3/06 ,  C07F7/00 ,  C07F7/0805 ,  C07F7/0838 ,  C07F7/0872 ,  C07F7/0879 ,  C07F7/0889 ,  C07F7/0896 ,  C07F7/1804 ,  C07F7/1876 ,  C07F7/1896 ,  C07F9/5045 ,  C07F9/60 ,  C07F11/005 ,  C07F13/00 ,  C07F13/005 ,  C07F15/0033 ,  C07F15/0046 ,  C07F15/02 ,  C07F15/065 ,  C08G77/08 ,  C09K3/00 ,  G07F13/00

摘要： A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand.

公开(公告)号：EP3371291A1

公开(公告)日：2018-09-12

申请号：EP16862920.2

申请日：2016-11-03

申请人： International Flavors & Fragrances Inc.

发明人： CANNON, Robert J. ,  JANCZUK, Adam Jan ,  AGYEMANG, David O. ,  CURTO, Nicole L. ,  CHEN, Zhen ,  CAI, Tingwei ,  VUICH, Cynthia M. ,  NORDMAN, II, Kurt E. ,  DE ABREU, Ingo F.F.

IPC分类号： C11B9/00 ,  C07D333/16 ,  A23L27/20 ,  A61K8/49 ,  A61Q11/00

CPC分类号： C07D333/22 ,  A23L27/2052 ,  C11B9/0011 ,  C11B9/0076

摘要： The present invention is directed to novel organoleptic compounds, a process of augmenting, enhancing or imparting taste to a material selected from the group consisting of a foodstuff, a chewing gum, a dental product, an oral hygiene product and a medicinal product comprising the step of incorporating an olfactory acceptable amount of such novel organoleptic compounds, and a process of improving, enhancing or modifying a fragrance formulation through the addition of an olfactory acceptable amount of such novel organoleptic compounds.

公开(公告)号：EP3339301A3

公开(公告)日：2018-08-08

申请号：EP18152189.9

申请日：2012-10-18

申请人： Sirrus, Inc.

发明人： MALOFSKY, Bernard Miles ,  MALOFSKY, Adam Gregg ,  DEY, Tanmoy ,  SULLIVAN, Jeffrey M.

IPC分类号： C07D333/22 ,  C07D333/24 ,  C07D307/46 ,  C07D307/54 ,  C08F20/14

CPC分类号： C08F20/28 ,  C07C45/75 ,  C07C49/794 ,  C07C49/796 ,  C07C49/798 ,  C07C49/80 ,  C07C67/03 ,  C07C67/30 ,  C07C69/604 ,  C07C69/738 ,  C07D307/46 ,  C07D307/54 ,  C07D333/22 ,  C07D333/24 ,  C08F20/14 ,  C08F20/30 ,  C08F20/38 ,  C08F20/68 ,  C08F22/20 ,  C08F24/00 ,  C08F28/06 ,  C08F116/36 ,  C08F128/06 ,  C08F222/1006 ,  C08F222/14 ,  C08K3/013 ,  C08K5/0008 ,  C08L21/00 ,  C08L33/14 ,  C08L33/16 ,  C08L35/02 ,  C09D4/00 ,  C09D129/12 ,  C09D133/14 ,  C09D133/16 ,  C09D135/02 ,  C09D141/00 ,  C09J133/06 ,  C09J133/14 ,  C09J133/16 ,  C09J135/02 ,  Y02P20/127

摘要： The present invention provides multifunctional monomers, including, but not limited to include multifunctional methylene malonate and methylene beta-ketoester monomers; methods for producing the same; and compositions and products formed therefrom. The multifunctional monomers of the invention may be produced by transesterification or by direct synthesis from monofunctional methylene malonate monomers or methylene beta-ketoester monomers. The present invention further compositions and products formed from methylene beta-ketoester monomers of the invention, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).

公开(公告)号：EP3272736A1

公开(公告)日：2018-01-24

申请号：EP16202251.1

申请日：2004-05-19

申请人： NOVARTIS AG

发明人： Pan, Shifeng ,  Gao, Wenqi ,  Gray, Nathanael ,  Mi, Yuan ,  Fan, Yi

IPC分类号： C07D205/04 ,  C07D207/16 ,  C07D211/60 ,  C07D213/30 ,  C07D213/61 ,  C07D217/04 ,  C07D307/52 ,  C07D333/12 ,  A61K31/135 ,  A61P29/00 ,  C07D307/10 ,  C07D307/12 ,  C07D333/16 ,  C07D333/22 ,  C07C251/48 ,  C07C251/52 ,  C07C251/54 ,  C07D295/06 ,  C07D213/53

CPC分类号： C07D205/04 ,  C07C251/48 ,  C07C251/52 ,  C07C251/54 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D207/16 ,  C07D211/60 ,  C07D213/30 ,  C07D213/53 ,  C07D213/61 ,  C07D217/04 ,  C07D295/06 ,  C07D307/10 ,  C07D307/12 ,  C07D307/52 ,  C07D333/12 ,  C07D333/16 ,  C07D333/22

摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.

摘要翻译： 本发明涉及免疫抑制剂，其制备方法，其用途和含有它们的药物组合物。 本发明提供了一类新型化合物，用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG受体介导的信号转导相关的疾病。

公开(公告)号：EP2768872B1

公开(公告)日：2017-11-22

申请号：EP12846728.9

申请日：2012-10-18

申请人： Sirrus, Inc.

发明人： MALOFSKY, Bernard Miles ,  MALOFSKY, Adam Gregg ,  DEY, Tanmoy ,  SULLIVAN, Jeffrey M.

IPC分类号： C08F16/36 ,  C07D333/22 ,  C07D307/46 ,  C07C69/38

CPC分类号： C08F20/28 ,  C07C45/75 ,  C07C49/794 ,  C07C49/796 ,  C07C49/798 ,  C07C49/80 ,  C07C67/03 ,  C07C67/30 ,  C07C69/604 ,  C07C69/738 ,  C07D307/46 ,  C07D307/54 ,  C07D333/22 ,  C07D333/24 ,  C08F20/14 ,  C08F20/30 ,  C08F20/38 ,  C08F20/68 ,  C08F22/20 ,  C08F24/00 ,  C08F28/06 ,  C08F116/36 ,  C08F128/06 ,  C08F222/1006 ,  C08F222/14 ,  C08K3/013 ,  C08K5/0008 ,  C08L21/00 ,  C08L33/14 ,  C08L33/16 ,  C08L35/02 ,  C09D4/00 ,  C09D129/12 ,  C09D133/14 ,  C09D133/16 ,  C09D135/02 ,  C09D141/00 ,  C09J133/06 ,  C09J133/14 ,  C09J133/16 ,  C09J135/02 ,  Y02P20/127

摘要： The present invention provides methylene beta-ketoester monomers, methods for producing the same, and compositions and products formed therefrom. In the method for producing the methylene beta-ketoesters of the invention, a beta-ketoester is reacted with a source of formaldehyde in a modified Knoevenagel reaction optionally in the presence of an acidic or basic catalyst, and optionally in the presence of an acidic or non-acidic solvent, to form reaction complex. The reaction complex may be an oligomeric complex. The reaction complex is subjected to further processing, which may be vaporization by contact with an energy transfer means in order to isolate the beta-ketoester monomer. The present invention further compositions and products formed from methylene beta-ketoester monomers of the invention, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).

公开(公告)号：EP2562253B1

公开(公告)日：2017-08-02

申请号：EP11771784.3

申请日：2011-01-28

申请人： KANEKA CORPORATION ,  National University Corporation Nara Institute of Science and Technology

发明人： NISHIHACHIJYO Masakatsu ,  IGUCHI Keita ,  KAWANO Shigeru ,  YASOHARA Yoshihiko

IPC分类号： C12N1/21 ,  C12N5/10 ,  C12P7/02 ,  C07D333/16 ,  C07D333/20 ,  C07D453/02 ,  C12N9/04 ,  C12P17/12 ,  C12P17/00

CPC分类号： C07D217/02 ,  C07D333/16 ,  C07D333/20 ,  C07D333/22 ,  C07D453/02 ,  C12N9/0006 ,  C12P7/02 ,  C12P17/00 ,  C12P17/12 ,  C12Y101/011

公开(公告)号：EP3019553A4

公开(公告)日：2017-03-15

申请号：EP14823671

申请日：2014-06-30

申请人： BASF SE

发明人： ZHOU MI ,  BRUNETTI FULVIO G ,  MARTIN EMMANUEL ,  BECKER STEFAN ,  DOI IORI ,  SANTOSO RAISSA NATHANIA ,  LAM MEI SHAN

IPC分类号： C07C247/16 ,  C07D333/20 ,  C07D333/22 ,  C08F28/06 ,  C08F32/02 ,  C08J3/00 ,  C08K5/00 ,  H01L51/05

CPC分类号： H01L21/02118 ,  C07C247/16 ,  C07C2603/18 ,  C07D333/20 ,  C07D333/22 ,  C08J3/24 ,  C08J3/28 ,  C08J2325/06 ,  C08K5/28 ,  C08K5/45 ,  C09D125/06 ,  H01L51/0018 ,  H01L51/052 ,  H01L51/0541 ,  H01L51/0545

摘要： The present invention provides compounds of formula a process for their preparation, a solution comprising these compounds, a process for the preparation of a device using the solution, devices obtainable by the process and the use of the bis-azide-type compounds as cross-linkers.

摘要翻译： 本发明提供式Ⅰ化合物，其制备方法，包含这些化合物的溶液，制备使用该溶液的装置的方法，通过该方法可获得的装置和双叠氮化物型化合物作为交联剂的用途， 接头。

公开(公告)号：EP2768917A4

公开(公告)日：2016-10-05

申请号：EP12842316

申请日：2012-10-18

申请人： SIRRUS INC

发明人： MALOFSKY BERNARD MILES ,  MALOFSKY ADAM GREGG ,  DEY TANMOY ,  HINES LARRY ,  ELLISON MATTHEW MCBRAYER

IPC分类号： C07C69/74 ,  C08F222/10 ,  C09J133/06

CPC分类号： C08F20/28 ,  C07C45/75 ,  C07C49/794 ,  C07C49/796 ,  C07C49/798 ,  C07C49/80 ,  C07C67/03 ,  C07C67/30 ,  C07C69/604 ,  C07C69/738 ,  C07D307/46 ,  C07D307/54 ,  C07D333/22 ,  C07D333/24 ,  C08F20/14 ,  C08F20/30 ,  C08F20/38 ,  C08F20/68 ,  C08F22/20 ,  C08F24/00 ,  C08F28/06 ,  C08F116/36 ,  C08F128/06 ,  C08F222/1006 ,  C08F222/14 ,  C08K3/0033 ,  C08K3/013 ,  C08K5/0008 ,  C08L21/00 ,  C08L33/14 ,  C08L33/16 ,  C08L35/02 ,  C09D4/00 ,  C09D129/12 ,  C09D133/14 ,  C09D133/16 ,  C09D135/02 ,  C09D141/00 ,  C09J133/06 ,  C09J133/14 ,  C09J133/16 ,  C09J135/02 ,  Y02P20/127

摘要： The present invention provides methylene beta-ketoester monomers, methods for producing the same, and compositions and products formed therefrom. In the method for producing the methylene beta-ketoesters of the invention, a beta-ketoester is reacted with a source of formaldehyde in a modified Knoevenagel reaction optionally in the presence of an acidic or basic catalyst, and optionally in the presence of an acidic or non-acidic solvent, to form reaction complex. The reaction complex may be an oligomeric complex. The reaction complex is subjected to further processing, which may be vaporization by contact with an energy transfer means in order to isolate the beta-ketoester monomer. The present invention further compositions and products formed from methylene beta-ketoester monomers of the invention, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).

摘要翻译： 本发明提供的多官能单体，包括但不限于包括多官能亚甲基丙二酸酯和亚甲基β-酮酯单体; 其制造方法; 和组合物以及产品由其形成。 本发明的多官能单体可以通过酯交换反应或通过从单官能单体亚甲基丙二酸二乙酯或亚甲基β-酮酯单体直接合成来制造。 本发明进一步的组合物和产品的本发明的亚甲基β-酮酯单体，包括基于单体产品（例如，油墨，粘合剂，涂料，密封剂或反应性模塑）和基于聚合物的产品（例如，纤维，膜，片形成 ，医疗聚合物，复合材料的聚合物和表面活性剂）。

公开(公告)号：EP2155643B1

公开(公告)日：2016-08-10

申请号：EP08770492.0

申请日：2008-06-09

申请人： MannKind Corporation

发明人： PATTERSON, John, Bruce ,  LONERGAN, David, Gregory ,  FLYNN, Gary A. ,  ZHENG, Qingping ,  PALLAI, Peter V.

IPC分类号： C07C47/54 ,  C07C47/548 ,  C07D213/24 ,  C07D215/12 ,  C07D217/14 ,  C07D295/00 ,  C07D333/10 ,  C07D275/03 ,  A61K31/33

CPC分类号： C07C65/21 ,  A61K31/11 ,  A61K31/135 ,  A61K31/166 ,  A61K31/192 ,  A61K31/357 ,  A61K31/381 ,  A61K31/505 ,  A61K31/5375 ,  A61K31/5377 ,  C07C47/55 ,  C07C47/565 ,  C07C47/575 ,  C07C65/11 ,  C07C65/26 ,  C07C65/30 ,  C07C205/44 ,  C07C205/61 ,  C07C223/02 ,  C07C233/65 ,  C07C235/42 ,  C07C235/84 ,  C07C251/24 ,  C07C317/24 ,  C07C321/04 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/48 ,  C07D213/64 ,  C07D213/69 ,  C07D213/74 ,  C07D215/14 ,  C07D217/16 ,  C07D231/12 ,  C07D235/08 ,  C07D239/26 ,  C07D239/54 ,  C07D241/18 ,  C07D249/18 ,  C07D261/08 ,  C07D277/34 ,  C07D295/125 ,  C07D295/15 ,  C07D295/192 ,  C07D307/80 ,  C07D317/54 ,  C07D319/08 ,  C07D319/18 ,  C07D321/10 ,  C07D333/22 ,  C07D333/58 ,  C07D401/12 ,  C07D403/12 ,  C07D417/10 ,  Y02A50/389 ,  Y02A50/393

摘要： Methods of treating disorders associated with unfolded protein response and methods of inhibiting IRE-1± activity are provided.