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公开(公告)号：EP2662081A1
公开(公告)日：2013-11-13
申请号：EP12167268.7
申请日：2012-05-09
申请人： NOSCIRA, S.A. , Smith, Andrew
CPC分类号： A61K31/4178 , G01N33/56983 , G01N33/686 , G01N33/6887 , G01N33/6893 , G01N33/6896
摘要： The present invention is related to the use of indole-dihydro-imidazole derivatives of Formula (I) as a medicament for the treatment of diseases or conditions mediated by Cdk5 and/or GSK3.
摘要翻译： 本发明涉及式（I）的吲哚 - 二氢 - 咪唑衍生物作为治疗由Cdk5和/或GSK3介导的疾病或病症的药物的用途。
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公开(公告)号：EP1586319B1
公开(公告)日：2009-10-21
申请号：EP05075779.8
申请日：2005-04-04
申请人： Noscira, S.A.
发明人： Martinez, Gil , Dorronsoro Diaz, Isabel , Alonso Cascon, Mercedes , Panizodel Pliego, Gema , Fuertes Huerta, Ana , Perez Puerto, Maria José , Medina Padilla, Miguel
IPC分类号： A61K31/433 , C07D285/08 , C07D417/04 , A61P25/28 , A61P3/10
CPC分类号： C07D285/08 , C07D417/04
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3.发明公开Triple substituted phenanthroline derivatives for the treatment of neurodegenerative or heamatological diseases or conditions 审中-公开神经变性或血液学的疾病或病症的治疗中的三取代菲咯啉衍生物
公开(公告)号：EP2196466A1
公开(公告)日：2010-06-16
申请号：EP08382073.8
申请日：2008-12-10
申请人： NOSCIRA, S.A.
IPC分类号： C07D471/04 , A61K31/4745
CPC分类号： C07D471/04
摘要： The present invention relates to a new family of triple substituted phenantroline derivatives of formula (I), which are useful for the treatment or profilaxis of a neurodegenerative or haematological disease or condition, their use as a medicament, especially for treating a neurodegenerative or haematological disease or condition, and a pharmaceutical composition comprising the compounds.
摘要翻译： 本发明涉及式（I）的三重substituiertem菲咯啉衍生物，其是用于治疗或神经变性或血液学的疾病或病症，它们作为药物的用途的profilaxis有用的新家族，爱尤其用于治疗神经变性或血液学疾病 或病症，和包含所述化合物的药物组合物。
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4.发明公开[1,10]-phenanthroline derivatives for the treatment of neurodegenerative or haematological diseases 审中-公开[1,10] -Phenanthrolin-Derivate zur Behandlung neurodegenerativer oderhämatologischerErkrankungen
公开(公告)号：EP2002863A1
公开(公告)日：2008-12-17
申请号：EP07380167.2
申请日：2007-06-11
申请人： NOSCIRA, S.A.
发明人： Martínez Gil, Ana , Castro Morera, Ana , Medina Padilla, Miguel , Sánchez-Quesada, Jorge , Alonso Cascón, Mercedes , Rubio Arrieta, Laura , García Palomero, Esther , Usán Egea, Paola
IPC分类号： A61P25/16 , A61P25/28 , A61P3/10 , A61K31/4745 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to a new family of [1,10]-phenantroline derivatives of formula (I), which are useful for the treatment or profilaxis of a neurodegenerative or haematological disease or condition, their use as a medicament, especially for treating a treatment neurodegenerative or haematological disease or condition, and a pharmaceutical composition comprising the compounds.
摘要翻译： 本发明涉及式（I）的[1,10] - phen啉衍生物的新家族，它们可用于治疗或表现神经变性或血液病学疾病或病症，其用作药物，特别是用于治疗 治疗神经变性或血液病或病症，以及包含该化合物的药物组合物。
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5.发明公开
公开(公告)号：EP2647634A1
公开(公告)日：2013-10-09
申请号：EP12382133.2
申请日：2012-04-02
申请人： NOSCIRA, S.A.
发明人： Medina Padilla, Miguel , Dominguez Correa, Juan Manuel , Fuertes Huerta, Ana , Palomo Nicolau, Francisco , Lopez Ogalla, Javier , Herrero Santos, Susana , Alonso Cascon, Mercedes , Alonso Gordillo, Diana , Rubio Arrieta, Laura
IPC分类号： C07D403/04 , A61K31/506 , A61P25/00 , A61P3/10
CPC分类号： C07D403/04
摘要： The present invention relates to new indole-pyrimidine derivatives of Formula (I), a process for obtaining them, a pharmaceutical composition comprising said compounds and their use in the treatment of several disease including cognitive, neurodegenerative or neurological diseases or conditions, diabetes, inflammatory and autoimmune diseases and cardiovascular disorders.
摘要翻译： 本发明涉及式（I）的新的吲哚 - 嘧啶衍生物，其获得方法，包含所述化合物的药物组合物及其在治疗包括认知，神经变性或神经疾病或病症，糖尿病，炎性 和自身免疫性疾病和心血管疾病。
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6.发明公开Use of collismycin and derivatives thereof as oxidative stress inhibitors 审中-公开Verwendung von Collismycin und Derivaten davon als oxidative Stresshemmer
公开(公告)号：EP2444121A1
公开(公告)日：2012-04-25
申请号：EP12151913.6
申请日：2006-07-28
发明人： Martínez Gil, Ana , Castro Morera, Ana , Alonso Cascón, Mercedes , Sánchez Quesada, Jorge , Usán Egea, Paola , Medina Padilla, Miguel , García Palomero, Esther , Pérez Baz, Julia , Fernández Chimeno, Rosa Isabel , Fernández Medarde, Antonio , Cañedo Hernández, Librada María , Romero Millán, Francisco
CPC分类号： A61K31/44
摘要： The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer's Disease and Parkinson's Disease.
摘要翻译： 本发明涉及Collismycin及其衍生物作为细胞氧化应激抑制剂及其在制备用于治疗和/或预防氧化应激诱发的疾病或病症，特别是神经变性疾病如阿尔茨海默病的药物中的应用。 疾病和帕金森病。
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7.发明公开Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders 审中-公开认知，神经变性或神经元疾病或病症的治疗呋喃咪唑酮衍生物
公开(公告)号：EP2281824A1
公开(公告)日：2011-02-09
申请号：EP09382139.5
申请日：2009-08-07
申请人： NOSCIRA, S.A.
发明人： Medina Padilla, Miguel , Sànchez-Quesada, Jorge , Herrero Santos, Susana , Garcià Palomero, Esther
IPC分类号： C07D405/06 , C07D405/14 , C07D413/14 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/506 , A61P25/00
CPC分类号： C07D405/06 , C07D405/14 , C07D413/14
摘要： The present invention is related to a family of furan-imidazolone derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same.
摘要翻译： 本发明涉及一种家庭式（I）的呋喃衍生物咪唑啉酮，并涉及它们在认知，神经变性或神经元性疾病或病症，：如阿尔茨海默氏病或帕金森氏病的治疗中的用途。 因此，本发明涉及药物组合物，其包括相同的。
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公开(公告)号：EP1646622B1
公开(公告)日：2010-11-03
申请号：EP04743319.8
申请日：2004-07-09
申请人： NOSCIRA, S.A.
发明人： Martinez Gil, Ana , Dorronsoro Diaz, Isabel , Rubio Arrieta, Laura , Alonso Gordillo, Diana , Fuertes Huerta, Ana , Morales-Alcelay, Susana , Del Monte Millan, Maria , Garcia Palomero, Esther , Usan Egea, Paola , De Austria, Celia , Medina Padilla, Miguel , Munoz Ruiz, Pilar
IPC分类号： C07D401/12 , A61K31/473 , A61P25/28
CPC分类号： C07D401/12
摘要： The invention provides compounds of formula: (I) which have a tacrine moiety connected to an heterocyclic moiety through a linker. Through careful selection of the substituents and the linker, the activity and selectivity towards acetylcholinesterase can be modulated. The compounds show potent AChE inhibition activities together with modifications in the β-amyloid aggregation properties by binding simultaneously to the catalytic and peripheral AChE sites. They are useful in the treatment of AChE mediated diseases, such as the Alzheimer’s disease.
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