摘要:
A computerized method for determining an objective tumor response to an anti-cancer therapy using one or more cross-sectional images can comprise receiving one or more cross-sectional images that comprise one or more cross-sectional slices of digital medical image data and identifying one or more target lesions within the one or more cross-sectional images. The method can also comprise analyzing at least one of the target lesions with an image-processing module configured to identify a total range of pixel intensities and restrict the total range of pixel intensities to a first restricted range that corresponds to pixel intensities representative of vascularized tumor. Further still, the method can comprise deriving a vascular tumor burden for the at least one of the one or more target lesions and determining the objective tumor response for the at least one of the one or more target lesions based on the vascular tumor burden.
摘要:
The present invention is related to the use of indole-dihydro-imidazole derivatives of Formula (I) as a medicament for the treatment of diseases or conditions mediated by Cdk5 and/or GSK3.
摘要:
The invention comprises a level sensor (1) for providing an indication of liquid level in a container comprising: an ultrasonic transducer for emitting an ultrasonic signal to the surface of the liquid and for detecting a return signal, reflected from the surface, a controller that instructs the transducer to emit ultrasonic signals and receives an indication that a return signal has been detected, the controller comprising a timer for measuring the time period between emission of the ultrasonic signal and receipt of a return signal, the determined time period providing an indication of the liquid level, and a radio transmitter that receives an indication of the liquid level and transmits a radio liquid level signal comprising the level indication to a remote output unit.
摘要:
A computer-implemented method for determining and evaluating an objective tumor response to an anti-cancer therapy using cross-sectional images can include receiving cross-sectional images of digital medical image data and identifying target lesions within the cross-sectional images. For each of the target lesions, a target lesion type and anatomical location is identified, a segmenting tool is activated for segmenting the target lesions into regions of interest, lesion metrics are automatically extracted from the regions of interest according to tumor response criteria, and conformity of target lesion identification is monitored using rules associated with the tumor response criteria, prompting a user to address any nonconforming target lesion. The method also includes receiving a presence/absence of metastases, determining changes in lesions metrics, and deriving an objective tumor response based on the tumor response criteria.
摘要:
A mammography system using a tissue exposure control relying on estimates of the thickness of the compressed and immobilized breast (20 and 22) and of breast density (26, 28, 30 and 32) to automatically derive one or more technic factors (24). The system further uses a tomosynthesis arrangement that maintains the focus of an anti-scatter grid (12d) on the x-ray source (12a) and also maintains the field of view of the x-ray receptor (12c). Finally, the system finds an outline that forms a reduced field of view (48) that still encompasses the breast in the image (46), and uses for further processing, transmission or archival storage the data within said reduced field of view (48).
摘要:
A railway carriage to be transported on a railway system includes a living area (164), a bathroom (36), a sleeping area (26) and a kitchen area (62). Appliances (40, 42, 75) in the bathroom (36) and kitchen area (62) are connected to a common potable water supply system (170). The railway carriage includes a potable water connector (136) to releasably connect the potable water supply system (170) of the carriage to an external water supply. The appliances (40, 42, 73) in the bathroom (36) and kitchen area (62) are also connected to a common waste water system (172). The railway carriage includes a waste water connector (138) to releasably connect the waste water system (172) of the carriage to an external waste system, such as a drain. The potable water connector (136) and the waste water connector (138) are provided on a common mounting (132).
摘要:
A gas monitoring system and method are provided. In one embodiment, a gas monitoring system includes a gas monitoring unit in a reactor containment environment, a gas monitoring unit controller in a reactor non-containment environment, and a high temperature or industry compliant cable interconnecting the gas monitoring unit with the gas monitoring unit controller. Various sensors on the gas monitoring unit detect conditions of the reactor containment environment, including hydrogen gas concentration.
摘要:
A rear-mounted aerodynamic structure for securing to a cargo body includes a three- or four-sided structure having a deployed position for assisting in improving aerodynamic efficiency of the cargo body. The cargo body can be the body of a trailer of a tractor-trailer vehicle or trailer towed behind a vehicle such as a truck. It can comprise a trailer body or other cargo body well-known in the art. A spoiler "flow keeper" mounted to a top surface of the rear of the cargo body, as additional aerodynamic structures or as a standalone spoiler for cargo bodies. The three- or four-sided rear-mounted aerodynamic structure can comprise any of a variety of illustrative embodiments shown and described herein.