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公开(公告)号：EP1658289A2
公开(公告)日：2006-05-24
申请号：EP04781205.2
申请日：2004-08-16
发明人： CASTELHANO, Arlindo, L. , CREW, Andrew, Phillip , DONG, Han-Qing , LAUFER, Radoslaw , LI, An-Hu , QIU, Li , SAMBROOK SMITH, Colin, Peter , ZHANG, Tao
IPC分类号： C07D471/04 , A61K31/435 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds represented by Formula (I): (I) or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
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公开(公告)号：EP1658289B1
公开(公告)日：2009-03-18
申请号：EP04781205.2
申请日：2004-08-16
发明人： CASTELHANO, Arlindo, L. , CREW, Andrew, Phillip , DONG, Han-Qing , LAUFER, Radoslaw , LI, An-Hu , QIU, Li , SAMBROOK SMITH, Colin, Peter , ZHANG, Tao
IPC分类号： C07D471/04 , A61K31/435 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds represented by Formula (I): (I) or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
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公开(公告)号：EP1664021A1
公开(公告)日：2006-06-07
申请号：EP04781204.5
申请日：2004-08-16
发明人： BOLGER, Joshua , CASTELHANO, Arlindo, L. , CREW, Andrew, Philip , DONG, Han-Qing , HONDA, Ayako , LAUFER, Radoslaw , LI, An-Hu , MULVIHILL, Kristen , QUI, Li , SAMBROOK, SMITH, Colin, Peter , SUN, Yingchuan , WYNNE, Graham, Michael , ZHANG, Tao
IPC分类号： C07D401/12 , C07D405/14 , C07D401/14 , C07D417/14 , C07D409/14 , C07D235/06 , C07D405/12 , C07D403/12 , A61K31/4184 , A61K31/4439 , A61P35/00
CPC分类号： C07D235/06 , C04B35/632 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/14
摘要： Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
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公开(公告)号：EP1957496B1
公开(公告)日：2012-10-24
申请号：EP06844779.6
申请日：2006-12-04
发明人： CREW, Andrew Philip , DONG, Han-Qing , MULVIHILL, Mark Joseph , WERNER, Douglas S. , KADALBAJOO, Mridula , LAUFER, Radoslaw
IPC分类号： C07D487/04 , A61P35/00 , A61P31/00 , A61P29/00 , A61K31/4985
CPC分类号： C07D487/04
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5.发明授权6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS 有权WITH A 6.6双环环取代的杂二环蛋白激酶抑制剂
公开(公告)号：EP1740591B1
公开(公告)日：2009-06-17
申请号：EP05742128.1
申请日：2005-03-31
发明人： ARNOLD, Lee, D. , CESARIO, Cara , COATE, Heather , CREW, Andrew, Philip , DONG, Hanqing , FOREMAN, Kenneth , HONDA, Ayako , LAUFER, Radoslaw , LI, An-Hu , MULVIHILL, Kristen, Michelle , MULVIHILL, Mark, Joseph , NIGRO, Anthony , PANICKER, Bijoy , STEINIG, Arno, G. , SUN, Yingchuan , WENG, Qinghua , WERNER, Douglas, S. , WYLE, Michael, J. , ZHANG, Tao
IPC分类号： C07D487/04 , C07D471/04 , A61K31/437 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/53 , A61P11/06 , A61P17/06 , A61P25/00 , A61P35/00
CPC分类号： C07F5/025 , C07D471/04 , C07D487/04
摘要： Compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein XI, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
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6.发明公开N-SUBSTITUTED BENZIMIDAZOLYL C-KIT INHIBITORS AND COMBINATORIAL BENZIMIDAZOLE LIBRARY 有权N-取代的苯并咪唑基-C-KIT抑制剂及其组合BENZIMIDAZOLBIBLIOTHEK
公开(公告)号：EP1831206A2
公开(公告)日：2007-09-12
申请号：EP05852400.0
申请日：2005-11-30
发明人： CREW, Andrew, Philip , COX, Matthew , LAUFER, Radoslaw , SUN, Yingchuan , PEGG, Neil, Anthony , SAMBROOK SMITH, Colin, Peter , WILKES, Robin, David , WILLIAMS, Jonathan
IPC分类号： C07D409/14
CPC分类号： C07D235/06 , C07B2200/11 , C07D401/12 , C07D403/10 , C07D403/14 , C07D405/10 , C07D409/10 , C07D409/14 , C07D413/10 , C07D417/14 , C40B40/00
摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt or N-oxide thereof act as c-kit inhibitors and are useful in the treatment of tumors. Combinatorial libraries composed of compounds represented by Formula (I) or benzimidazole compounds represented by Formula (II) are useful in providing compounds to assay for such therapeutically useful compounds.
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7.发明授权N-SUBSTITUTED BENZIMIDAZOLYL C-KIT INHIBITORS AND COMBINATORIAL BENZIMIDAZOLE LIBRARY 有权N-取代的苯并咪唑基-C-KIT抑制剂及其组合BENZIMIDAZOLBIBLIOTHEK
公开(公告)号：EP1831206B1
公开(公告)日：2011-08-24
申请号：EP05852400.0
申请日：2005-11-30
发明人： CREW, Andrew, Philip , COX, Matthew , LAUFER, Radoslaw , SUN, Yingchuan , PEGG, Neil, Anthony , SAMBROOK SMITH, Colin, Peter , WILKES, Robin, David , WILLIAMS, Jonathan
IPC分类号： C07D409/14
CPC分类号： C07D235/06 , C07B2200/11 , C07D401/12 , C07D403/10 , C07D403/14 , C07D405/10 , C07D409/10 , C07D409/14 , C07D413/10 , C07D417/14 , C40B40/00
摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt or N-oxide thereof act as c-kit inhibitors and are useful in the treatment of tumors. Combinatorial libraries composed of compounds represented by Formula (I) or benzimidazole compounds represented by Formula (II) are useful in providing compounds to assay for such therapeutically useful compounds.
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8.发明授权
公开(公告)号：EP1664032B1
公开(公告)日：2008-11-05
申请号：EP04781203.7
申请日：2004-08-16
发明人： BOLGER, Joshua , CASTELHANO, Arlindo, L. , CREW, Andrew, Phillip , LAUFER, Radoslaw , LI, An-Hu , SAMBROOK SMITH, Colin Peter , SUN, Yingchuan
IPC分类号： C07D403/12 , A61K31/4184 , A61K31/4155 , A61P35/00
CPC分类号： C07D403/12
摘要： Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
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公开(公告)号：EP1957496A2
公开(公告)日：2008-08-20
申请号：EP06844779.6
申请日：2006-12-04
发明人： CREW, Andrew Philip , DONG, Han-Qing , MULVIHILL, Mark Joseph , WERNER, Douglas S. , KADALBAJOO, Mridula , LAUFER, Radoslaw
IPC分类号： C07D487/04 , A61P35/00 , A61P31/00 , A61P29/00 , A61K31/4985
CPC分类号： C07D487/04
摘要： Compounds of the Formula (I) and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit protein kinase enzymes and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
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10.发明公开6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS 有权WITH A 6.6双环环取代的杂二环蛋白激酶抑制剂
公开(公告)号：EP1740591A1
公开(公告)日：2007-01-10
申请号：EP05742128.1
申请日：2005-03-31
发明人： ARNOLD, Lee, D. , CESARIO, Cara , COATE, Heather , CREW, Andrew, Philip , DONG, Hanqing , FOREMAN, Kenneth , HONDA, Ayako , LAUFER, Radoslaw , LI, An-Hu , MULVIHILL, Kristen, Michelle , MULVIHILL, Mark, Joseph , NIGRO, Anthony , PANICKER, Bijoy , STEINIG, Arno, G. , SUN, Yingchuan , WENG, Qinghua , WERNER, Douglas, S. , WYLE, Michael, J. , ZHANG, Tao
IPC分类号： C07D487/04 , C07D471/04 , A61K31/437 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/53 , A61P11/06 , A61P17/06 , A61P25/00 , A61P35/00
CPC分类号： C07F5/025 , C07D471/04 , C07D487/04
摘要： Compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein XI, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
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