公开(公告)号：EP1019501A1

公开(公告)日：2000-07-19

申请号：EP98907199.8

申请日：1998-03-12

申请人： OTSUKA PHARMACEUTICAL CO., LTD.

发明人： YAMADA, Satoshi ,  KINOSHITA, Naosumi ,  YASUMURA, Koichi ,  EDAMATSU, Koji ,  NAGAHAMA, Takao ,  ISHIKAWA, Shintaro ,  YAMAUCHI, Takeshi ,  KISHI, Kazumasa ,  SUGIYAMA, Kazuhisa

IPC分类号： C12N15/12

CPC分类号： C07D487/04

摘要： The present invention provides a novel pyrimidine derivative represented by general formula (1), wherein R, R?4 and R8¿ are the same as defined in the specification, or pharmaceutically acceptable salt thereof, which possesses an excellent activity for inhibiting the formation of NO (nitrogen oxide) in vivo.