公开(公告)号：EP2341932A1

公开(公告)日：2011-07-13

申请号：EP09754195.7

申请日：2009-05-27

申请人： Ooo "Npt Mbp Gormezis"

发明人： ONIKIENKO, Sergey B. ,  ZEMLYANOI, Alexander V. ,  MARGULIS, Boris, A. ,  GUZHOVA, Irina V. ,  PIMENOVA, Anna, A.

IPC分类号： A61K39/145 ,  A61K39/29

CPC分类号： A61K39/39 ,  A61K39/0015 ,  A61K39/095 ,  A61K39/12 ,  A61K39/145 ,  A61K39/292 ,  A61K41/00 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/70 ,  A61N1/327 ,  C12N2730/10134 ,  C12N2760/16134 ,  C12N2760/18434 ,  C12N2760/18734 ,  C12N2770/36234

摘要： The invention is directed to methods of administering a vaccine to a subject by exposing an area of an epidermal layer of skin or mucosa of the subject to a high-energy pulsed electric field in conjunction with administration of the vaccine. In the methods, the electric field does not cause visible skin damage or significant or irreversible damage to cells in the exposed area. The electric field acts as an adjuvant for the vaccine, increasing the efficacy and/or potency of the vaccine.

公开(公告)号：EP2341932B1

公开(公告)日：2016-11-09

申请号：EP09754195.7

申请日：2009-05-27

申请人： Ooo "Npt Mbp Gormezis"

发明人： ONIKIENKO, Sergey B. ,  ZEMLYANOI, Alexander V. ,  MARGULIS, Boris, A. ,  GUZHOVA, Irina V. ,  PIMENOVA, Anna, A.

IPC分类号： A61K39/145 ,  A61K39/29 ,  A61K39/39 ,  A61K39/12 ,  A61N1/32

CPC分类号： A61K39/39 ,  A61K39/0015 ,  A61K39/095 ,  A61K39/12 ,  A61K39/145 ,  A61K39/292 ,  A61K41/00 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/70 ,  A61N1/327 ,  C12N2730/10134 ,  C12N2760/16134 ,  C12N2760/18434 ,  C12N2760/18734 ,  C12N2770/36234