公开(公告)号：EP2678043B1

公开(公告)日：2018-04-25

申请号：EP12750134.4

申请日：2012-02-24

申请人： University Of Georgia Research Foundation, Inc.

发明人： HE, Biao

IPC分类号： C12N7/00 ,  C07K16/10 ,  C07K16/24 ,  A61K48/00 ,  A61K38/08 ,  A61P31/12 ,  A61P31/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/155 ,  A61K39/165

CPC分类号： A61K39/165 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/543 ,  C07K16/1027 ,  C07K16/241 ,  C07K2317/34 ,  C12N7/00 ,  C12N2760/18534 ,  C12N2760/18721 ,  C12N2760/18734 ,  C12N2760/18743 ,  C12N2760/18762

摘要： The present invention provides the complete genomic sequence of the epidemic mumps virus (MuV) strain MuVIowa/us/06. Further, a reverse genetics system was constructed and used to rescue recombinant viral constructs that are attenuated compared to MuVIowa/us/06 and JL vaccine viruses. Such constructs include viral constructs lacking the open reading frame (ORF) of the SH gene (rMuVΔSH) and/or incapable of expressing the V protein (rMuVΔV).

公开(公告)号：EP2341932B1

公开(公告)日：2016-11-09

申请号：EP09754195.7

申请日：2009-05-27

申请人： Ooo "Npt Mbp Gormezis"

发明人： ONIKIENKO, Sergey B. ,  ZEMLYANOI, Alexander V. ,  MARGULIS, Boris, A. ,  GUZHOVA, Irina V. ,  PIMENOVA, Anna, A.

IPC分类号： A61K39/145 ,  A61K39/29 ,  A61K39/39 ,  A61K39/12 ,  A61N1/32

CPC分类号： A61K39/39 ,  A61K39/0015 ,  A61K39/095 ,  A61K39/12 ,  A61K39/145 ,  A61K39/292 ,  A61K41/00 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/70 ,  A61N1/327 ,  C12N2730/10134 ,  C12N2760/16134 ,  C12N2760/18434 ,  C12N2760/18734 ,  C12N2770/36234

公开(公告)号：EP2940134A4

公开(公告)日：2016-08-10

申请号：EP13868750

申请日：2013-12-25

申请人： BIOCOMO INC ,  UNIV MIE

发明人： FUKUMURA MASAYUKI ,  OHTSUKA JUNPEI ,  NOSAKA TETSUYA ,  TSURUDOME MASATO ,  KAWANO MITSUO ,  HARA KEN-ICHIRO

IPC分类号： C12N15/09 ,  A61K39/145 ,  A61K39/155 ,  A61K48/00 ,  A61P31/16 ,  A61P35/00 ,  C12N7/02 ,  C12N7/04

CPC分类号： C12N15/86 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K2039/5252 ,  A61K2039/5256 ,  C07K2319/00 ,  C12N7/00 ,  C12N15/09 ,  C12N2760/16034 ,  C12N2760/18734 ,  C12N2760/18743 ,  C12N2760/18762 ,  C12N2760/18763

摘要： Disclosed are: a virus vector in which a gene encoding an antigenic polypeptide is integrated in human parainfluenza virus type 2 gene, wherein the antigenic polypeptide is expressed in the form of a fusion protein with a viral structural protein; and a method for producing the same. The virus vector of the present invention contains a quantitatively large amount of the antigenic peptide on the virus particle and can efficiently deliver the antigenic polypeptide to a target cell.

公开(公告)号：EP1572947B1

公开(公告)日：2014-06-25

申请号：EP03752537.5

申请日：2003-09-18

申请人： The United States Of America, As Represented By The Secretary, Department Of Health & Human Services

发明人： SKIADOPOULOS, Mario, H. ,  MURPHY, Brian, R. ,  COLLINS, Peter, L.

IPC分类号： C12N7/00 ,  C12N7/01 ,  C12Q1/70 ,  A01N63/00

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  C12N7/00 ,  C12N2760/18334 ,  C12N2760/18634 ,  C12N2760/18643 ,  C12N2760/18722 ,  C12N2760/18734 ,  C12N2760/18743 ,  C12N2760/18762

公开(公告)号：EP2678043A2

公开(公告)日：2014-01-01

申请号：EP12750134.4

申请日：2012-02-24

申请人： University Of Georgia Research Foundation, Inc.

发明人： HE, Biao

IPC分类号： A61K48/00 ,  A61K38/08 ,  A61P31/12 ,  A61P31/00

CPC分类号： A61K39/165 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/543 ,  C07K16/1027 ,  C07K16/241 ,  C07K2317/34 ,  C12N7/00 ,  C12N2760/18534 ,  C12N2760/18721 ,  C12N2760/18734 ,  C12N2760/18743 ,  C12N2760/18762

摘要： The present invention provides the complete genomic sequence of the epidemic mumps virus (MuV) strain MuVIowa/us/06. Further, a reverse genetics system was constructed and used to rescue recombinant viral constructs that are attenuated compared to MuVIowa/us/06 and JL vaccine viruses. Such constructs include viral constructs lacking the open reading frame (ORF) of the SH gene (rMuVΔSH) and/or incapable of expressing the V protein (rMuVΔV).

摘要翻译： 本发明提供了流行性腮腺炎病毒（MuV）菌株MuVIowa / us / 06的完整基因组序列。 此外，构建反向遗传学系统并用于拯救与MuVIowa / us / 06和JL疫苗病毒相比减毒的重组病毒构建体。 这样的构建体包括缺乏SH基因（rMuVDeltaSH）的开放阅读框（ORF）和/或不能表达V蛋白（rMuVDeltaV）的病毒构建体。

公开(公告)号：EP2670431A1

公开(公告)日：2013-12-11

申请号：EP12705437.7

申请日：2012-02-03

申请人： Zoetis LLC

发明人： ABDELMAGID, Omar, Yousif ,  BRICKER, Joseph, Michael ,  SHIELDS, Shelly, Lynn

IPC分类号： A61K39/145 ,  A61K39/215 ,  A61K39/10

CPC分类号： A61K39/295 ,  A61K39/099 ,  A61K39/12 ,  A61K39/145 ,  A61K39/215 ,  A61K2039/521 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/55577 ,  A61K2039/70 ,  C12N2710/10334 ,  C12N2760/16134 ,  C12N2760/18734 ,  C12N2770/20034

摘要： Provided herein are compositions comprising a canine influenza virus and a canine respiratory coronavirus. They can further comprise Bordetella bronchiseptica, pertactin, canine parainfluenza virus, and canine adenovirus serotype 2. The compositions are effective for treating or preventing canine respiratory diseases, including canine infectious respiratory disease complex.

摘要翻译： 本文提供了包含犬流感病毒和犬呼吸冠状病毒的组合物。 它们可以进一步包括支气管炎博德特氏菌，百日速肽，副流感病毒和犬腺病毒血清型2.该组合物对于治疗或预防犬呼吸系统疾病，包括犬传染性呼吸系统疾病复合物是有效的。

公开(公告)号：EP2150624A1

公开(公告)日：2010-02-10

申请号：EP08767903.1

申请日：2008-05-28

申请人： Wyeth LLC

发明人： WU, Stephen, Qitu ,  GILL, Michael, A. ,  CHU, Hsien-Jue

IPC分类号： C12Q1/68 ,  C12Q1/70 ,  A61K39/275

CPC分类号： A61K39/205 ,  A61K39/0225 ,  A61K39/12 ,  A61K2039/521 ,  A61K2039/5252 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N15/86 ,  C12N2710/10334 ,  C12N2710/24143 ,  C12N2750/14034 ,  C12N2760/18434 ,  C12N2760/18734 ,  C12N2760/20134 ,  C12N2770/20034

摘要： The present invention relates to recombinant raccoon poxvirus vectors that express the rabies virus glycoprotein gene at the hemagglutinin (ha) locus of the poxvirus genome or express the glycoprotein gene of the same or different rabies strains at the thymidine kinase (tk) and the hemagglutinin (ha) loci of the poxvirus genome, and their use as adjuvant-free vaccines. The raccoon poxvirus vector comprises the nucleic acid molecules encoding the glycoprotein of a Challenge Virus Standard rabies strain inserted and expressed at the tk locus of the poxvirus genome and of a Pasteur-Paris rabies strain inserted and expressed at the ha locus of the poxvirus genome. The vaccine may optionally contain a mixture of additional feline and canine antigens for immunization of animals. Also disclosed are methods for inducing an immune response to rabies in a mammal by administering to the mammal an effective immunizing amount of the vaccine of the invention.

公开(公告)号：EP1083883A1

公开(公告)日：2001-03-21

申请号：EP99955214.4

申请日：1999-05-28

申请人： MERCK & CO., INC.

发明人： VOLKIN, David, B. ,  BURKE, Carl, J. ,  SHEU, Su-Pi

IPC分类号： A61K9/19 ,  A61K31/045 ,  A61K39/12 ,  C07H3/04 ,  C12N7/00

CPC分类号： A61K39/165 ,  A61K9/0019 ,  A61K9/19 ,  A61K39/0015 ,  A61K39/12 ,  A61K39/13 ,  A61K39/20 ,  A61K39/25 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61K47/42 ,  A61K2039/5254 ,  A61K2039/70 ,  C12N2710/16734 ,  C12N2760/18434 ,  C12N2760/18734 ,  C12N2770/36234 ,  Y02A50/466

摘要： Vaccine stabilizers, vaccine formulations and lyophilized vaccines with enhanced thermostability are disclosed. The vaccine formulations comprise an increased amount of a 6-carbon polyhydric alcohol (such as sorbitol), an increase amount of a disaccharide (such as sucrose) and an amount of a physiologically active buffer to adjust the pH from about 6.0 to about 7.0.

公开(公告)号：EP0259438A4

公开(公告)日：1989-09-11

申请号：EP87901785

申请日：1987-01-20

申请人： MCMICHAEL JOHN

发明人： MCMICHAEL JOHN

IPC分类号： A61K38/00 ,  A61K31/415 ,  A61K35/76 ,  A61K38/39 ,  A61K39/00 ,  A61K39/165 ,  A61K39/395

CPC分类号： A61K31/415 ,  A61K35/76 ,  A61K38/39 ,  A61K39/0008 ,  A61K39/12 ,  A61K39/165 ,  A61K39/395 ,  A61K2039/5252 ,  A61K2039/542 ,  A61K2039/58 ,  C12N2760/16134 ,  C12N2760/18433 ,  C12N2760/18434 ,  C12N2760/18734 ,  Y10S424/81 ,  A61K2300/00

摘要： Disclosed are methods and compositions useful for alleviating the symptoms of rheumatoid arthritis. In preferred embodiments, the compositions are administered in essentially minute "neutralizing" doses. The compositions comprise mixtures of histamine, immunoglobulin G provocative of RF formation or an immunologically active fraction thereof, collagen and either attenuated measles virus or immunologically active fraction thereof. Illustratively significant relief of symptoms of arthritis disease symptoms is achieved through parenteral (e.g., subcutaneous or sublingual) administration of such compositions.

公开(公告)号：EP2702159B1

公开(公告)日：2018-07-25

申请号：EP12777657.3

申请日：2012-04-13

申请人： St. Jude Children's Research Hospital

发明人： HURWITZ, Julia, Lea ,  TAKIMOTO, Toru ,  RUSSELL, Charles, John ,  PORTNER, Allen ,  SLOBOD, Karen, S.

IPC分类号： C12N15/86 ,  C12N7/01 ,  A61K39/155 ,  C07K16/08 ,  C07K14/115 ,  A61K39/00

CPC分类号： C12N15/86 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K14/005 ,  C07K16/08 ,  C12N7/00 ,  C12N2760/18534 ,  C12N2760/18634 ,  C12N2760/18734 ,  C12N2760/18821 ,  C12N2760/18822 ,  C12N2760/18834 ,  C12N2760/18843

摘要： The present invention relates to a Sendai virus or recombinant Sendai virus vector. In particular the present invention provides methods, vectors, formulations, compositions, and kits for a modified Enders strain Sendai viral vector. An immunogenic vector can be used in any in vitro or in vivo system. Moreover, some embodiments include vectors for imaging virus growth, location and transmission.