公开(公告)号：EP4442300A2

公开(公告)日：2024-10-09

申请号：EP24171120.9

申请日：2016-12-28

申请人： Inovio Pharmaceuticals, Inc.

发明人： MCCOY, Jay ,  BRODERICK, Kate ,  KEMMERRER, Stephen

IPC分类号： A61M5/315

CPC分类号： A61M5/172 ,  A61M5/20 ,  A61M5/24 ,  A61M5/315 ,  A61K9/0021 ,  A61M5/30 ,  A61N1/327 ,  A61M2205/8220130101 ,  A61B17/205

摘要： An jet injection and electroporation device for use with an agent cartridge defining a volume containing a pre-measured dose of agent therein, the electroporation device including a housing having an axis extend therethrough, a nozzle at least partially positioned within the housing, and a cavity sized to receive at least a portion of the agent cartridge therein. The device also includes an array having a plurality of electrodes extending therefrom, a propulsion cartridge configured to operatively engage the cartridge when the agent cartridge is positioned within the cavity; and a power supply in electrical communication with the array.

公开(公告)号：EP4438058A2

公开(公告)日：2024-10-02

申请号：EP24180574.6

申请日：2012-06-28

申请人： Inovio Pharmaceuticals, Inc.

发明人： BRODERICK, Kate ,  KEMMERRER, Stephen ,  MCCOY, Jay

IPC分类号： A61K39/00

CPC分类号： A61N1/0424 ,  A61N1/0412 ,  A61N1/0476 ,  A61K2039/5320130101 ,  A61M2037/000720130101 ,  C12M35/02 ,  C12N15/87 ,  A61N1/327

摘要： The disclosure is directed to a device for electroporating and delivering one or more antigens and a method of electroporating and delivering one or more antigens to cells of epidermal tissues using the device. The device comprises a housing, a plurality of electrode arrays projecting from the housing, each electrode array including at least one electrode, a pulse generator electrically coupled to the electrodes, a programmable microcontroller electrically coupled to the pulse generator, and an electrical power source coupled to the pulse generator and the microcontroller. The electrode arrays define spatially separate sites.

公开(公告)号：EP4427693A2

公开(公告)日：2024-09-11

申请号：EP24190953.0

申请日：2020-09-01

申请人： Mirai Medical Limited

发明人： SODEN, Declan ,  FORDE, Colin ,  KINSELLA, Sean ,  MOORE, Tony

IPC分类号： A61B18/14

CPC分类号： A61N1/327 ,  A61B2018/0061320130101 ,  A61B18/1206 ,  C12M35/02 ,  A61B2018/0011320130101 ,  A61B2018/001620130101 ,  A61B2018/0076720130101 ,  A61B2018/12420130101 ,  A61B2018/14320130101 ,  A61B18/1477 ,  A61B2018/0087520130101

摘要： An electroporation apparatus comprises a plurality of electroporation probe (26) terminals (27) and a transformer (6) for providing stepped-up voltage. Also, there is a switching circuit (7) with switches (24, 25) for linking high voltage and low voltage or ground levels to the probe terminals (26). A controller (2, 4, 5) configured to control said switches according to a control scheme to deliver pulses to the probe terminals (27), and in which said pulses are delivered to groups of at least two probe electrode terminals for probe electrodes which are spaced apart. The controller maps data defining relative physical positions of probe terminals (P1-P7) to be connected to the terminals (27) and directs pulses for applying voltages across space bounded by the probe electrodes.

公开(公告)号：EP4395880A1

公开(公告)日：2024-07-10

申请号：EP22865719.3

申请日：2022-08-30

申请人： Nanovis, LLC

发明人： DETWILER, David A. ,  KRAFT, Alan M. ,  MCCARTHY, James T. ,  KISTLER, Gordon P.

IPC分类号： A61N1/32 ,  A61M31/00 ,  A61N1/00 ,  A61B5/282

CPC分类号： A61N1/327 ,  A61N1/0412 ,  A61M2037/000720130101 ,  A61M37/00 ,  A61M35/00

公开(公告)号：EP4044947B1

公开(公告)日：2024-06-12

申请号：EP20828482.8

申请日：2020-12-03

IPC分类号： A61B18/14 ,  A61N1/32

CPC分类号： A61B18/1492 ,  A61N1/327 ,  A61B2018/0061320130101 ,  A61B2018/0057720130101 ,  A61B2018/0035120130101 ,  A61B2017/0029220130101 ,  A61B2018/0026720130101 ,  A61B2018/143520130101 ,  A61B18/1206 ,  A61B2018/12820130101 ,  A61B2018/12420130101 ,  A61B2018/124620130101 ,  A61B2018/146720130101 ,  A61B2018/147520130101

公开(公告)号：EP3813927B1

公开(公告)日：2024-06-12

申请号：EP19769295.7

申请日：2019-08-29

IPC分类号： A61N1/32 ,  A61N1/05 ,  A61B18/14

CPC分类号： A61B18/1492 ,  A61B2018/002220130101 ,  A61B2018/0026720130101 ,  A61B2018/0043420130101 ,  A61B2018/0057720130101 ,  A61B2018/0063620130101 ,  A61B2018/0079120130101 ,  A61B2018/0087520130101 ,  A61B2018/0088620130101 ,  A61B2018/143520130101 ,  A61N1/05 ,  A61N1/327 ,  A61B2018/0021420130101 ,  A61B2018/0015420130101 ,  A61B2018/0061320130101 ,  A61B2018/0001120130101 ,  A61B5/053 ,  A61B5/6852 ,  A61B5/4836 ,  A61B5/685 ,  A61M25/10 ,  A61M2025/105220130101 ,  A61M2025/10520130101 ,  A61M2037/006120130101

公开(公告)号：EP3845159B1

公开(公告)日：2024-05-29

申请号：EP20217619.4

申请日：2020-12-29

IPC分类号： A61B17/29 ,  A61B18/14

CPC分类号： A61B17/072 ,  A61B17/29 ,  A61B17/320092 ,  A61B17/3468 ,  A61B18/1206 ,  A61B18/14 ,  A61B18/1445 ,  A61B18/16 ,  A61B2017/0001720130101 ,  A61B2017/0002620130101 ,  A61B2017/0007520130101 ,  A61B2017/0011520130101 ,  A61B2017/0032320130101 ,  A61B2017/0039820130101 ,  A61B2017/0073420130101 ,  A61B2017/292720130101 ,  A61B2017/292920130101 ,  A61B2017/32007420170801 ,  A61B2017/32009420170801 ,  A61B2018/0010720130101 ,  A61B2018/0011920130101 ,  A61B2018/0012520130101 ,  A61B2018/0020220130101 ,  A61B2018/0034520130101 ,  A61B2018/0058920130101 ,  A61B2018/0059520130101 ,  A61B2018/0060120130101 ,  A61B2018/0061320130101 ,  A61B2018/0061920130101 ,  A61B2018/006320130101 ,  A61B2018/0064220130101 ,  A61B2018/0066620130101 ,  A61B2018/0082720130101 ,  A61B2018/0087520130101 ,  A61B2018/0089220130101 ,  A61B2018/0098220130101 ,  A61B2018/0099420130101 ,  A61B2018/122620130101 ,  A61B2018/12420130101 ,  A61B2018/124620130101 ,  A61B2018/125320130101 ,  A61B2018/12620130101 ,  A61B2018/127320130101 ,  A61B2018/128620130101 ,  A61B2018/14420130101 ,  A61B2018/146520130101 ,  A61B2018/146720130101 ,  A61B2034/30520160201 ,  A61B2090/06520160201 ,  A61B2090/06620160201 ,  A61N1/327 ,  G06F3/016 ,  H05K1/0283 ,  H05K1/147 ,  H05K2201/0926320130101 ,  A61B2017/0022120130101 ,  A61B2018/0060720130101 ,  A61B2090/06420160201 ,  H02J7/0063 ,  H02J2310/2320200101

公开(公告)号：EP4358882A1

公开(公告)日：2024-05-01

申请号：EP22736379.3

申请日：2022-06-21

申请人： Acclarent, Inc.

发明人： PALUSHI, Jetmir ,  WRIGHT, Alison D. ,  BASU, Shubhayu ,  HOPKINS, Jeffrey D.

IPC分类号： A61B18/14 ,  A61B18/00 ,  A61B5/00 ,  A61N1/04 ,  A61N1/32

CPC分类号： A61B18/1485 ,  A61B2018/0057720130101 ,  A61B2018/0032720130101 ,  A61N1/0456 ,  A61N1/327 ,  A61B2018/0061320130101 ,  A61B5/4035 ,  A61B5/4047 ,  A61B5/294

公开(公告)号：EP2066399B1

公开(公告)日：2018-10-03

申请号：EP07839621.5

申请日：2007-10-17

申请人： Inovio Pharmaceuticals, Inc.

发明人： BROWN, Patricia A. ,  DRAGHIA-AKLI, Ruxandra ,  KHAN, Amir S. ,  POPE, Melissa A.

IPC分类号： A61N1/32 ,  A61N1/04

CPC分类号： A61N1/327 ,  A61N1/0412 ,  A61N1/0476

摘要： Aspects of the present invention relate to electroporation devices to effectively facilitate the introduction of a biomolecule into cells of a selected tissue in a body, in particular skin such as intradermic or subcutaneous tissue. In some aspects, the present invention is a skin EP device, which produces a pulse of energy and delivers same to the skin tissue using a skin electrode array and maintains a constant current in the same skin tissue based on user input, including a preset current, and allows the storage and acquisition of current waveform data.

公开(公告)号：EP2741785B1

公开(公告)日：2018-09-05

申请号：EP12840108.0

申请日：2012-07-12

申请人： Philadelphia Health and Education Corporation ,  Inovio Pharmaceuticals, Inc. ,  The Trustees of The University of Pennsylvania

发明人： KUTZLER, Michele ,  BALIBAN, Scott ,  WEINER, David, B. ,  SARDESAI, Niranjan, Y. ,  KIM, J. Joseph

IPC分类号： A61K48/00 ,  A61K39/08 ,  C12N15/17 ,  C12N15/31 ,  C12N15/85

CPC分类号： A61K39/08 ,  A61K2039/53 ,  A61N1/327 ,  C07K14/33

摘要： The invention relates to compositions and methods for treating C. difficile associated disease (CDAD) through the administration to a subject in need thereof at least one nucleic acid encoding at least a portion of at least one of toxin A and toxin B.