公开(公告)号：EP0880345B1

公开(公告)日：2006-04-05

申请号：EP97901455.2

申请日：1997-01-16

申请人： Osteotech, Inc.

发明人： DOWD, Michael ,  SCARBOROUGH, Nelson ,  DAUGHERTY, Mark ,  McMICKLE, Jack

IPC分类号： A61F2/28 ,  A61L27/00

CPC分类号： A61L27/3691 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/4644 ,  A61F2002/30957 ,  A61F2002/4649 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L27/3687 ,  A61L2430/40 ,  Y10S623/901 ,  Y10S623/919

摘要： A process for fabricating shaped material from demineralized bone particles includes the steps of applying a liquid slurry of demineralized bone particles to a support, removing excess liquid from the demineralized bone particles to provide a coherent shaped mass of demineralized bone particles (50), and warming the shaped mass of demineralized bone particles at a predetermined temperature and for a predetermined time period (60). The resultant bone mass exhibits enhanced tensile strength and minimal bone particle disassociation upon rehydration thereby improving product handling and application at the operative site.

公开(公告)号：EP0732947B1

公开(公告)日：2002-03-06

申请号：EP95904299.5

申请日：1994-12-08

申请人： OSTEOTECH, INC.,

发明人： DOWD, Michael ,  DYKE, Denis, G.

IPC分类号： A61L27/00 ,  A61K35/32

CPC分类号： A61L27/3847 ,  A61F2/28 ,  A61F2002/2839 ,  A61F2002/30677 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/3695

摘要： Surgically implantable shaped materials, e.g., sheets, are fabricated from elongate bone particles, advantageously those that have been demineralized. The materials when applied to a bone repair site enhance or accelerate new bone ingrowth by any one of a variety of biological and/or mechanical mechanisms.

公开(公告)号：EP0979109A1

公开(公告)日：2000-02-16

申请号：EP98911575.3

申请日：1998-03-11

申请人： Osteotech, Inc.,

发明人： SCARBOROUGH, Nelson, L. ,  MORRIS, John, W. ,  RUSSELL, James, L. ,  DOWD, Michael

IPC分类号： A61L27/00

CPC分类号： A61F2/4644 ,  A61F2/28 ,  A61F2002/4646 ,  A61K35/32 ,  A61L2/0088 ,  A61L2/18 ,  A61L27/36 ,  A61L27/3608 ,  A61L27/3683 ,  Y10S623/923

摘要： A pressure flow system and method for its use are provided for contacting the interior of a fluid permeable, e.g., porous, workpiece. The system includes a fluid pressure chamber having an inlet port and an opening formed in one of the chamber walls. An adjustable seal capable of providing a fluid-tight seal about the exterior of a workpiece having a non-uniform surface is positioned within the opening. Fluid under pressure is supplied to the pressure chamber to force fluid to flow through the internal matrix of the workpiece. In a preferred embodiment, the workpiece is a bone or a section thereof, and the fluid is forced to flow from the endosteal portion of bone to the periosteal portion of bone through the vasculature and porous structure of the bone to remove blood, bone marrow and/or other non-bone constituent(s) from the bone. Alternatively, the fluid can be chosen to decontaminate and/or demineralize the bone, to stain the bone to improve visualization of the bone microvasculature or to impregnate with pharmacological agents (antibiotics, bone growth factors, etc.) so that bone can act as a delivery system.

公开(公告)号：EP0979109B1

公开(公告)日：2003-11-19

申请号：EP98911575.3

申请日：1998-03-11

申请人： Osteotech, Inc.,

发明人： SCARBOROUGH, Nelson, L. ,  MORRIS, John, W. ,  RUSSELL, James, L. ,  DOWD, Michael

IPC分类号： A61L27/00

CPC分类号： A61F2/4644 ,  A61F2/28 ,  A61F2002/4646 ,  A61K35/32 ,  A61L2/0088 ,  A61L2/18 ,  A61L27/36 ,  A61L27/3608 ,  A61L27/3683 ,  Y10S623/923

摘要： A pressure flow system and method for its use are provided for contacting the interior of a fluid permeable, e.g., porous, workpiece. The system includes a fluid pressure chamber having an inlet port and an opening formed in one of the chamber walls. An adjustable seal capable of providing a fluid-tight seal about the exterior of a workpiece having a non-uniform surface is positioned within the opening. Fluid under pressure is supplied to the pressure chamber to force fluid to flow through the internal matrix of the workpiece. In a preferred embodiment, the workpiece is a bone or a section thereof, and the fluid is forced to flow from the endosteal portion of bone to the periosteal portion of bone through the vasculature and porous structure of the bone to remove blood, bone marrow and/or other non-bone constituent(s) from the bone. Alternatively, the fluid can be chosen to decontaminate and/or demineralize the bone, to stain the bone to improve visualization of the bone microvasculature or to impregnate with pharmacological agents (antibiotics, bone growth factors, etc.) so that bone can act as a delivery system.

公开(公告)号：EP0732947A1

公开(公告)日：1996-09-25

申请号：EP95904299.0

申请日：1994-12-08

申请人： OSTEOTECH, INC.

发明人： DOWD, Michael ,  DYKE, Denis, G.

IPC分类号： A61L27 ,  A61F2

CPC分类号： A61L27/3847 ,  A61F2/28 ,  A61F2002/2839 ,  A61F2002/30677 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/3695

摘要： Surgically implantable shaped materials, e.g., sheets, are fabricated from elongate bone particles, advantageously those that have been demineralized. The materials when applied to a bone repair site enhance or accelerate new bone ingrowth by any one of a variety of biological and/or mechanical mechanisms.

公开(公告)号：EP1347793A2

公开(公告)日：2003-10-01

申请号：EP01991103.1

申请日：2001-12-14

申请人： Osteotech, Inc.,

发明人： MORRIS, John ,  SHIMP, Lawrence, A. ,  PETERSEN, Kenneth, C. ,  MANRIQUE, Albert ,  KAES, David ,  SCARBOROUGH, Nelson, L. ,  DOWD, Michael

IPC分类号： A61L27/36

CPC分类号： A61L27/3847 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L27/3691 ,  A61L2430/02 ,  A61L2430/40

摘要： Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.

公开(公告)号：EP0880345A1

公开(公告)日：1998-12-02

申请号：EP97901455.0

申请日：1997-01-16

申请人： Osteotech, Inc.,

发明人： DOWD, Michael ,  SCARBOROUGH, Nelson ,  DAUGHERTY, Mark ,  McMICKLE, Jack

IPC分类号： A61F2 ,  A61L27

CPC分类号： A61L27/3691 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/4644 ,  A61F2002/30957 ,  A61F2002/4649 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L27/3687 ,  A61L2430/40 ,  Y10S623/901 ,  Y10S623/919

摘要： A process for fabricating shaped material from demineralized bone particles includes the steps of applying a liquid slurry of demineralized bone particles to a support, removing excess liquid from the demineralized bone particles to provide a coherent shaped mass of demineralized bone particles (50), and warming the shaped mass of demineralized bone particles at a predetermined temperature and for a predetermined time period (60). The resultant bone mass exhibits enhanced tensile strength and minimal bone particle disassociation upon rehydration thereby improving product handling and application at the operative site.