公开(公告)号：EP3370790A1

公开(公告)日：2018-09-12

申请号：EP16816444.0

申请日：2016-11-04

申请人： Tovarystvo Z Obmezhenoyu Vidpovidal'nistyu "A.A. Partners"

发明人： OKSYMETS, Volodymyr Mykhaylovych ,  ZUBOV, Dmytro Oleksandrovych ,  VASYLIEV, Roman Hennadiyovych

IPC分类号： A61L27/22 ,  A61L27/24 ,  A61L27/36 ,  A61L27/38

CPC分类号： A61L27/3821 ,  A61L27/225 ,  A61L27/24 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3654 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/3886 ,  A61L27/52 ,  A61L2430/02 ,  A61L2430/06

摘要： Method of the osteoreparative processes' correction and/or bone defect restoration by means of human cell-based products (cell and/or tissue transplants) and the method of its manufacturing. The invention a creates and establishes conditions for osteoreparative processes restoration in destroyed bone tissue by osteoreparation cell sources restoration as the result of use cell technologies and bone tissue engineering methods, e.g. scaffold-guided regeneration, particularly by means of cell transplantation by injection and/or transplantation of original three-dimensional osteoreparative prevascularized graft (3D-OPG). Manufacturing of medical products and preparations of the product based on human cells (cell and/or tissue transplants) is dedicated for impaired osteoreparative processes correction and/or bone defect restoration.

公开(公告)号：EP2652127B1

公开(公告)日：2018-04-04

申请号：EP11848447.6

申请日：2011-12-15

申请人： Health Corporation - Rambarn

发明人： ZIGDON-GILADI, Hadar ,  LEWINSON, Dina ,  BICK, Tova ,  MACHTEI, Eli

IPC分类号： A61F2/28 ,  C12N5/0775 ,  C12N5/071 ,  A61L27/12 ,  A61L27/22 ,  A61L27/24 ,  A61L27/38

CPC分类号： A61F2/28 ,  A61L27/12 ,  A61L27/225 ,  A61L27/24 ,  A61L27/3808 ,  A61L27/3821 ,  A61L27/3847 ,  C12N5/0663 ,  C12N5/0668 ,  C12N5/0692 ,  C12N2533/54 ,  C12N2533/80

摘要： A method of facilitating augmentation of osseous tissue on a surface of a bone is disclosed. The method includes combining a scaffolding, an enclosure substantially enclosing the scaffolding relatively to the surface of the bone and a cell culture seeded onto the scaffolding.

公开(公告)号：EP3269399A1

公开(公告)日：2018-01-17

申请号：EP17182553.2

申请日：2014-12-12

申请人： Agnovos Healthcare, LLC

发明人： Moseley, Jon ,  MacDougall, Jamie ,  Harrigan, Katie

IPC分类号： A61L24/02 ,  C04B35/447

CPC分类号： A61L27/12 ,  A61L24/0015 ,  A61L24/02 ,  A61L27/025 ,  A61L27/3608 ,  A61L27/3641 ,  A61L27/3821 ,  A61L27/3847 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/10 ,  A61L2300/102 ,  A61L2300/112 ,  A61L2300/414 ,  A61L2400/06 ,  A61L2430/02 ,  C04B28/14 ,  C04B28/34 ,  C04B2111/00836 ,  C04B11/00 ,  C04B20/002 ,  C04B20/008 ,  C04B20/0096 ,  C04B24/04 ,  C04B40/065

摘要： The invention provides a particulate composition adapted for forming a bone graft substitute cement upon mixing with an aqueous solution, comprising i) a calcium sulfate hemihydrate powder, wherein the calcium sulfate hemihydrate is present at a concentration of at least about 50 weight percent based on the total weight of the particulate composition; ii) a monocalcium phosphate monohydrate powder; iii) a non-porous β-tricalcium phosphate powder; and iv) a porous β-tricalcium phosphate powder. Bone graft substitute cements made therefrom, a bone graft substitute kit comprising the particulate composition, methods of making and using the particulate composition, and articles made from the bone graft substitute cement are also provided.

摘要翻译： 本发明提供了适于在与水溶液混合时形成骨移植替代物水泥的颗粒组合物，其包含i）半水合硫酸钙粉末，其中所述半水合硫酸钙以至少约50重量％的浓度存在 颗粒组合物的总重量; ii）一水磷酸一钙粉末; iii）无孔β-磷酸三钙粉末; 和iv）多孔β-磷酸三钙粉末。 还提供由其制造的骨移植替代物粘固剂，包含该颗粒组合物的骨移植替代试剂盒，制备和使用该颗粒组合物的方法以及由该骨移植替代物粘固剂制成的制品。

公开(公告)号：EP3038621A4

公开(公告)日：2017-08-09

申请号：EP14763792

申请日：2014-03-17

申请人： HUMAN BIOMOLECULAR RES INST

发明人： CASHMAN JOHN R ,  RYAN DANIEL R ,  CHEN SIGENG

IPC分类号： A61K31/4706 ,  A61K31/12 ,  A61K31/47 ,  A61K31/4704 ,  A61K31/519 ,  A61K33/42 ,  A61K35/28 ,  A61K38/18 ,  A61K45/06 ,  A61L27/12 ,  A61L27/38 ,  A61P19/00 ,  C07D215/44 ,  C07D487/04 ,  G01N33/50

CPC分类号： A61L27/3895 ,  A61K31/12 ,  A61K31/4706 ,  A61K31/519 ,  A61K33/42 ,  A61K35/28 ,  A61K38/18 ,  A61K45/06 ,  A61L27/12 ,  A61L27/28 ,  A61L27/32 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/425 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/112 ,  A61L2300/412 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/06 ,  A61L2430/02 ,  A61L2430/40 ,  C07C49/248 ,  C07C49/255 ,  C07C225/22 ,  C07C229/40 ,  C07D215/44 ,  C07D487/04 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/502 ,  G01N33/5044 ,  G01N2333/916 ,  A61K2300/00

摘要： Compositions of small molecules, matrices, and isolated cells including methods of preparation, and methods for differentiation, transdifferentiation, and proliferation of animal cells into the osteoblast blast cell lineage were described. Examples of osteogenic materials that were administered to cells or co-cultured with cells are represented by compounds of Formula II, IV, and VI independently or preferably in combination with a matrix to afford bone cells. Small molecule-stimulated cells were also combined with a matrix, placed with a cellular adhesive or material carrier and implanted to a site in an animal for bone repair. Matrix pretreated with compounds of Formula II, IV, and VI were also used to cause cells to migrate to the matrix that is of use for therapeutic purposes.

摘要翻译： 描述了小分子，基质和分离细胞的组合物，包括制备方法，以及用于将动物细胞分化，转分化和增殖至成骨细胞胚细胞谱系的方法。 施用于细胞或与细胞共培养的成骨材料的实例独立地或优选地与基质组合以提供骨细胞的式II​​，IV和VI的化合物表示。 还将小分子刺激的细胞与基质组合，放置有细胞粘合剂或材料载体并植入动物中的部位以进行骨修复。 用式II，IV和VI化合物预处理的基质也用于使细胞迁移至用于治疗目的的基质。

公开(公告)号：EP3180043A1

公开(公告)日：2017-06-21

申请号：EP15763210.0

申请日：2015-08-17

申请人： The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of Holy and Undiv. Trinity of Queen Elizabeth near Dublin

发明人： KELLY, Daniel John ,  CUNNIFFE, Grainne ,  ALMEIDA, Henrique ,  ESWARAMOORTHY, Rajalakshmanan ,  BUCKLEY, Conor ,  DIAZ PEYNO, Pedro ,  BROWE, David

IPC分类号： A61L27/36 ,  A61L27/38 ,  A61L27/44 ,  A61L27/52 ,  A61L27/56

CPC分类号： A61L27/3633 ,  A61L27/3612 ,  A61L27/365 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/3817 ,  A61L27/3821 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/44 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2430/02 ,  A61L2430/06 ,  A61L2430/40

摘要： A method for making a porous devitalised scaffold suitable for use in repair of osseous, chondral, or osteochondral defects in a mammal comprises the steps of providing micronized extracellular matrix (ECM) tissue, mixing the micronized extracellular matrix with a liquid to provide a slurry, and freeze-drying the slurry to provide the porous scaffold. A porous scaffold suitable for use in repair of osseous, chondral, or osteochondral defects in a mammal and comprising a porous freeze-dried matrix formed from micronised decellularised extracellular matrix tissue is also described.

摘要翻译： 一种制备多孔devitalised支架适合于在骨的修复中使用的方法，在哺乳动物中软骨或骨软骨缺损包括提供微粉化的细胞外基质（ECM）的组织中，微粉化的细胞外基质与液体混合，以提供浆料的步骤， 和冷冻干燥，以提供多孔支架的浆料。 适合于在骨的修复，在哺乳动物中软骨所以或骨软骨缺损使用和包含微粉化脱细胞的细胞外基质的组织形成的多孔冻干基质的多孔支架进行说明。

公开(公告)号：EP3129075A1

公开(公告)日：2017-02-15

申请号：EP15777375.5

申请日：2015-04-09

申请人： Bonus Therapeutics Ltd.

发明人： MERETZKI, Shai

IPC分类号： A61L27/38 ,  A61K35/12 ,  A61K35/28 ,  A61K31/728

CPC分类号： A61L27/3891 ,  A61K31/728 ,  A61K35/28 ,  A61K35/44 ,  A61L27/12 ,  A61L27/20 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/46 ,  A61L27/58 ,  A61L2400/06 ,  A61L2430/02 ,  A61K2300/00 ,  C08L5/08

摘要： A composition including, (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid, is provided. Moreover, a kit which includes: a syringe, a mineral particle covered with endothelial cells and mesenchymal cells organized in 2 or more cell layers attached to the mineral particle, and hyaluronic acid, is also provided. Last, a method for filling a gap in a bone of a subject in need thereof, including contacting the gap with a composition of: (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid is provided.

摘要翻译： 提供了包含（a）矿物颗粒，（b）内皮细胞和间充质细胞和（3）透明质酸的组合物。 此外，还提供了一种试剂盒，其包括：注射器，覆盖有内皮细胞的矿物颗粒和组织在连接到矿物颗粒的2个或更多个细胞层中的间充质细胞和透明质酸。 最后，一种用于填补有需要的受试者的骨头中的间隙的方法，包括使间隙与以下组合物接触：（a）矿物质颗粒，（b）内皮细胞和间充质细胞，和（3）透明质酸是 提供。

公开(公告)号：EP2674172B1

公开(公告)日：2017-02-15

申请号：EP12171457.0

申请日：2012-06-11

申请人： Ludwig Boltzmann Gesellschaft

发明人： Feichtinger, Georg ,  Mc Hale, Anthony P. ,  Nomikou, Nikolitsa ,  Redl, Heinz

IPC分类号： A61K9/00 ,  A61K48/00

CPC分类号： A61L27/20 ,  A61K9/0009 ,  A61K48/0008 ,  A61K48/0083 ,  A61L27/225 ,  A61L27/24 ,  A61L27/3813 ,  A61L27/3821 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/258 ,  A61L2430/02

公开(公告)号：EP3122269A1

公开(公告)日：2017-02-01

申请号：EP14887019.9

申请日：2014-03-25

申请人： Cormatrix Cardiovascular, Inc.

发明人： MATHENY, Robert, G.

IPC分类号： A61B17/58 ,  A61F2/28 ,  A61K38/18

CPC分类号： A61K35/32 ,  A61F2/28 ,  A61K35/28 ,  A61K35/545 ,  A61K45/06 ,  A61L27/3608 ,  A61L27/3633 ,  A61L27/365 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2430/02

摘要： A bioresorbable skeletal construct member formed from an osteoinductive composition comprising autogenic bone and an extracellular matrix (ECM) material, the construct member being configured to induce osteoanagenesis and angiogenesis when implanted proximate endogenous bone and tissue.

摘要翻译： 由包含自身骨和细胞外基质（ECM）材料的骨诱导组合物形成的生物可再吸收的骨骼构建构件，所述构建构件被配置为当植入邻近内源性骨和组织时诱导骨形成和发生。

公开(公告)号：EP3111965A1

公开(公告)日：2017-01-04

申请号：EP16183850.3

申请日：2009-11-16

申请人： AlloSource

发明人： SHI, Yaling

IPC分类号： A61L27/12 ,  A61L27/38 ,  A61K47/02 ,  C12N5/0775 ,  A01N1/02 ,  A61K35/12 ,  A61K35/38 ,  A61L27/36 ,  A61L27/54

CPC分类号： A61L27/3834 ,  A01N1/021 ,  A61K35/12 ,  A61K35/38 ,  A61L27/3608 ,  A61L27/3847 ,  A61L27/3895 ,  A61L27/54 ,  A61L2300/406 ,  A61L2430/02 ,  C12N5/0662 ,  C12N5/0667 ,  C12N2509/00 ,  C12N2533/18 ,  C12N2533/90

摘要： There is disclosed a method of combining mesenchymal stem cells (MSCs) with a bone substrate. In an embodiment, the method includes obtaining tissue having MSCs together with unwanted cells. The tissue is digested to form a cell suspension having MSCs and unwanted cells. The cell suspension is added to the substrate. The substrate is cultured to allow the MSCs to adhere. The substrate is rinsed to remove unwanted cells. In various embodiments, the tissue is adipose issue, muscle tissue, or bone marrow tissue. In an embodiment, there is disclosed an allograft product including a combination of MSCs with a bone substrate in which the combination is manufactured by culturing MSCs disposed on the substrate for a period of time to allow the MSCs to adhere to the substrate, and then rinsing the substrate to remove unwanted cells from the substrate. Other embodiments are also disclosed.

摘要翻译： 公开了将间充质干细胞（MSC）与骨基质组合的方法。 在一个实施方案中，该方法包括获得具有MSC的组织和不想要的细胞。 将组织消化以形成具有MSC和不想要的细胞的细胞悬液。 将细胞悬浮液加入到底物中。 培养基质以允许MSC粘附。 漂洗底物以除去不需要的细胞。 在各种实施方案中，组织是脂肪问题，肌肉组织或骨髓组织。 在一个实施方案中，公开了一种同种异体移植物产品，其包括MSC与骨基质的组合，其中通过将设置在基质上的MSC培养一段时间来制备组合，以允许MSC粘附到基质上，然后冲洗 底物以从基底去除不需要的细胞。 还公开了其它实施例。

公开(公告)号：EP3102251A1

公开(公告)日：2016-12-14

申请号：EP15746508.9

申请日：2015-02-06

申请人： Globus Medical, Inc.

发明人： BHAT, Archana ,  LASKOWITZ, Dan ,  JOE, Patrick ,  ADAMS, Mark ,  BOYER II, Michael Lee

IPC分类号： A61L27/38 ,  A61L27/00

CPC分类号： A61L27/3821 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3834 ,  A61L27/3847 ,  A61L2430/02

摘要： Provided herein are bone grafts and methods of making and using the same, as well as products and kits that include such bone grafts. In particular, bone grafts are provided that include osteogenic stem cells in a mix of osteoinductive demineralized bone matrix and osteoconductive cortico-cancellous chips.

摘要翻译： 本文提供了骨移植物及其制备和使用方法，以及包括这种骨移植物的产品和试剂盒。 特别地，提供骨移植物，其包括成骨诱导的软骨骨架和骨诱导性皮质松质骨碎片混合中的成骨干细胞。