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公开(公告)号：EP1494624B1
公开(公告)日：2010-06-30
申请号：EP03726166.6
申请日：2003-03-31
申请人： Osteotech, Inc.
CPC分类号： A61L27/3683 , A01N1/00 , A61F2/4644 , A61F2002/2835 , A61F2002/4645 , A61F2002/4649 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L2430/02 , A61L2430/40
摘要： The present invention relates to a method for making bone particles from bone of a variety of sizes and a workpiece forming and holding device for use with the method. The workpiece forming device includes a base and a base frame attached to the surface of the base. An apparatus for forming a solidified mass of bone and immobilization medium is also provided which includes the workpiece forming device and a detachable former member enclosing the base frame. Bone is immersed in an immobilization medium within such workpiece forming device, which is solidified to form a solidified mass of bone and immobilization medium and then subdivided to provide particles of bone in association to with immobilization medium. The immobilization medium may be optionally removed to leave bone particles suitable for use in orthopedic applications including implants.
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公开(公告)号：EP1589962A2
公开(公告)日：2005-11-02
申请号：EP04708211.0
申请日：2004-02-04
申请人： Osteotech, Inc.
IPC分类号： A61K31/26
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
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公开(公告)号：EP1528938A2
公开(公告)日：2005-05-11
申请号：EP03785276.1
申请日：2003-08-12
申请人： Osteotech, Inc.
IPC分类号： A61L27/26
CPC分类号： A61L27/48 , A61L27/3608 , A61L27/46 , A61L2430/02 , C08L89/00
摘要： A method of producing a bone-polymer composite comprises the steps of providing a plurality of bone particles, combining the bone particles with a polymer precursor, and polymerizing the polymer precursor.
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公开(公告)号：EP1341484A2
公开(公告)日：2003-09-10
申请号：EP01993238.3
申请日：2001-12-07
CPC分类号： A61F2/08
摘要： An implant for orthopedic applications includes a quantity of flexible, elongated elements at least some of which possess connective tissue-healing activity, the elongated elements being arranged in substantially common alignment along their longitudinal axis.
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公开(公告)号：EP1701672A2
公开(公告)日：2006-09-20
申请号：EP04815132.8
申请日：2004-12-20
申请人： Osteotech, Inc.
发明人： GEREMAKIS, Perry, A. , GRASSO, Jennifer , KNAACK, David , LIN, Jo-Wen , SHIMP, Lawrence, A. , WATERMAN, Robert , WINTERBOTTOM, John, M.
CPC分类号： A61L27/3641 , A61B17/06166 , A61B2017/00004 , A61F2/0063 , A61F2/28 , A61F2/3094 , A61F2/4455 , A61F2/4601 , A61F2/4644 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61F2310/00011 , A61F2310/00179 , A61F2310/00359 , A61L27/3608 , A61L27/3633 , A61L27/3645 , A61L27/3804 , A61L27/3843 , B29C67/02
摘要： An implant including a substantially cohesive aggregate comprising bone-derived particles. Cohesiveness is maintained by a member of mechanical interlocking, engagement of adjacent bone-derived particles with one another through engagement with a binding agent, thermal bonding, chemical bonding, or a matrix material in which the bone-derived particles are retained. The aggregate is shaped as a one-dimensional or two-dimensional body.
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公开(公告)号：EP1280564A2
公开(公告)日：2003-02-05
申请号：EP01935499.2
申请日：2001-05-14
申请人： Osteotech, Inc.,
发明人： EDWARDS, Jean, T. , SHIMP, Lawrence, A. , DIEGMANN, Michele , BOYCE, Todd, M. , SCARBOROUGH, Nelson, L. , RUSSELL, James, L.
IPC分类号： A61L27/36
CPC分类号： A61L27/3683 , A61L27/3608 , A61L27/365 , A61L2430/02
摘要： A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.
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公开(公告)号：EP2167148A2
公开(公告)日：2010-03-31
申请号：EP08771193.3
申请日：2008-06-16
申请人： Osteotech, Inc.,
发明人： SHIMP, Lawrence, A. , WEI, Guobao
CPC分类号： A61L27/3691 , A61F2/4644 , A61F2002/4646 , A61L27/30 , A61L27/34 , A61L27/3604 , A61L27/3847 , A61L27/48 , A61L27/50 , A61L2430/40 , C08L67/04
摘要： In one embodiment, the method comprises providing tissue, preparing the tissue, and treating the tissue to improve remodeling characteristics of the tissue. The tissue may be, for example, cortical bone. Treating the tissue to improve remodeling characteristics may comprise heating the tissue, treating the tissue with a chemical, or other. Heating the tissue may be done in the absence of oxygen and may comprise heating the tissue in a vacuum, heating the tissue in an inert atmosphere, heating the tissue in a reducing atmosphere, coating the tissue with a protective coating and heating the tissue, or other. Further embodiments comprise treating the tissue in supercritical fluids, for example, to dry or virally inactivate the tissue.
摘要翻译： 在一个实施方案中，该方法包括提供组织，制备组织和处理组织以改善组织的重塑特征。 组织可以是例如皮质骨。 处理组织以改善重塑特征可包括加热组织，用化学品或其它物质处理组织。 加热组织可以在没有氧的情况下进行，并且可以包括在真空中加热组织，在惰性气氛中加热组织，在还原气氛中加热组织，用保护涂层涂覆组织并加热组织，或 其他。 另外的实施方案包括处理超临界流体中的组织，例如干燥或病毒灭活组织。
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公开(公告)号：EP2129406A2
公开(公告)日：2009-12-09
申请号：EP08729687.7
申请日：2008-02-12
申请人： Osteotech, Inc.,
CPC分类号： A61L27/3604 , A61L15/325 , A61L15/40 , A61L27/24 , A61L31/005 , A61L31/044
摘要： Medical implants and methods for forming a medical implant blends a dispersion of human collagen fibers and/or threads and optionally a volume between about 2 to about 15% of an alcohol and forms medical implants by removing a liquid component of the collagen dispersion. Medical implants formed include collagen films, coatings, threads, patches, tubes, plugs, scaffolds, injectable collagen, and collagen for in vitro applications.
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公开(公告)号：EP1341484B1
公开(公告)日：2009-05-06
申请号：EP01993238.3
申请日：2001-12-07
CPC分类号： A61F2/08
摘要： An implant for orthopedic applications includes a quantity of flexible, elongated elements at least some of which possess connective tissue-healing activity, the elongated elements being arranged in substantially common alignment along their longitudinal axis.
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公开(公告)号：EP1981440A2
公开(公告)日：2008-10-22
申请号：EP07718273.1
申请日：2007-01-19
申请人： Osteotech, Inc.,
CPC分类号： A61L27/18 , A61F2/28 , A61F2002/2817 , A61F2310/00359 , A61K31/785 , A61L27/46 , A61L27/48 , C08G18/10 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04 , C08G18/36
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
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