公开(公告)号：EP0177361A2

公开(公告)日：1986-04-09

申请号：EP85307113.2

申请日：1985-10-04

申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.

发明人： Soti, Ferenc ,  Szantay, Csaba ,  Incze, Maria ,  Balogh, Zsuzsanna ,  Ezer, Elemer ,  Matuz, Judit ,  Szporny, Laszlo ,  Hajos, Gyorgy ,  Kuthi, Csaba

IPC分类号： C07D471/14 ,  A61K31/395

CPC分类号： C07D471/14

摘要： The invention relates to new 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl-alkanecarboxylic acid amides of the general formula (I),
wherein

R, and R 2 represent a hydrogen or halogen atom, or a hydroxyl, nitro or C 1-4 alkoxy group;
R 3 and R 4 represent a hydrogen atom or a C 1-4 alkyl group;
R 5 and R 6 represent a hydrogen atom, C 1-8 alkyl group, C 3-8 alkenyl or cycloalkyl group, aryl or aralkyl group, heteroaryl or heteroaralkyl goup containing oxygen, nitrogen or sulphur atom, all these goups being optionally substituted; or
R 5 and R 6 together represent a,w-alkyl group, wherein one carbon atom may optionally be replaced by an oxygen or nitrogen atom; and
G means a C 1-4 straight chained alkylidene group, as well as to their therapeutically useful acid addition salts and pharmaceutical compositions containing these compounds.

Furthermore, the invention relates to a process for preparing these compounds and compositions.
The compounds of the general formula (I) have valuable therapeutic properties, namely vasodilatory, spasmolytic, antiarrhythmic and gastrocytoprotective effects. The gastrocytoprotective effect is particularly important.

公开(公告)号：EP0050492B1

公开(公告)日：1984-08-15

申请号：EP81304833.7

申请日：1981-10-16

申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.

发明人： Szantay, Csaba ,  Szabo, Lajos ,  Kalaus, Gyorgy ,  Sapi, Janos ,  Kreidl, Janos ,  Farkas, Maria ,  Nemes, Andras ,  Czibula, Laszlo

IPC分类号： C07D471/14 ,  C07D471/22

CPC分类号： C07D471/14

公开(公告)号：EP0050492A1

公开(公告)日：1982-04-28

申请号：EP81304833.7

申请日：1981-10-16

申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.

发明人： Szantay, Csaba ,  Szabo, Lajos ,  Kalaus, Gyorgy ,  Sapi, Janos ,  Kreidl, Janos ,  Farkas, Maria ,  Nemes, Andras ,  Czibula, Laszlo

IPC分类号： C07D471/14 ,  C07D471/22

CPC分类号： C07D471/14

摘要： Compounds of general formula (A),
wherein

R 1 represents a C 1-4 alkyl group;
X represents a residue of an acid;
either B represents a group -COOR 2 (in which R 2 represents a C 1-4 alkyl group) and Z represents a group
(in which R 3 and R 5 , which may be the same or different, each represents a C 1-4 alkyl radical) or B represents a group -COOH or a hydrogen atom and Z represents a group -CH 2 COOH, of use in the enantioselective synthesis of optically active 14-oxo-E-homo-eburnane derivatives.

摘要翻译： 通式（A），... 的化合物，其中R 1表示C 1-4烷基; X表示酸的残基; B表示-COOR 2基团（其中 R 2表示C 1-4烷基），Z表示基团。其中R 3和R 5可以相同或不同，各自表示C 1-4烷基 基团）或B表示基团-COOH或氢原子，Z表示基团-CH 2 COOH，用于光学活性的14-氧代-E-异烟酸衍生物的对映选择性合成。

公开(公告)号：EP0177361A3

公开(公告)日：1987-09-02

申请号：EP85307113

申请日：1985-10-04

申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.

发明人： Soti, Ferenc ,  Szantay, Csaba ,  Incze, Maria ,  Balogh, Zsuzsanna ,  Ezer, Elemer ,  Matuz, Judit ,  Szporny, Laszlo ,  Hajos, Gyorgy ,  Kuthi, Csaba

IPC分类号： C07D471/14 ,  A61K31/395 ,  C07D221/00 ,  C07D209/00

CPC分类号： C07D471/14

摘要： The invention relates to new 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl-alkanecarboxylic acid amides of the general formula (I),
wherein
R, and R 2 represent a hydrogen or halogen atom, or a hydroxyl, nitro or C 1-4 alkoxy group; R 3 and R 4 represent a hydrogen atom or a C 1-4 alkyl group; R 5 and R 6 represent a hydrogen atom, C 1-8 alkyl group, C 3-8 alkenyl or cycloalkyl group, aryl or aralkyl group, heteroaryl or heteroaralkyl goup containing oxygen, nitrogen or sulphur atom, all these goups being optionally substituted; or R 5 and R 6 together represent a,w-alkyl group, wherein one carbon atom may optionally be replaced by an oxygen or nitrogen atom; and G means a C 1-4 straight chained alkylidene group, as well as to their therapeutically useful acid addition salts and pharmaceutical compositions containing these compounds. Furthermore, the invention relates to a process for preparing these compounds and compositions. The compounds of the general formula (I) have valuable therapeutic properties, namely vasodilatory, spasmolytic, antiarrhythmic and gastrocytoprotective effects. The gastrocytoprotective effect is particularly important.