公开(公告)号：EP3862742A1

公开(公告)日：2021-08-11

申请号：EP19869892.0

申请日：2019-09-30

申请人： NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY ,  RION Co., Ltd. ,  Kioxia Corporation

发明人： KATO, Haruhisa ,  MATSUURA, Yusuke ,  NAKAMURA, Ayako ,  KONDO, Kaoru ,  TABUCHI, Takuya ,  TOMITA, Hiroshi ,  HAYASHI, Hidekazu

IPC分类号： G01N15/02 ,  G01N15/00

摘要： To easily calibrate, using a calibration particle, a measuring device configured to capture an image of a target object such as a target particle. An image analyzer (21) acquires multiple images obtained at a predetermined time interval Δt, (a) specifies the mean-square displacement Δ MS-cal of a bright point of a calibration particle based on the displacement, in terms of a pixel unit, of the bright point of the calibration particle in the multiple images in a calibration mode, and (b) specifies the mean-square displacement Δ MS of a bright point of the target particle based on the displacement, in terms of the pixel unit, of the bright point of the target particle in the multiple images in a measuring mode. A particle size analyzer (22), (c) in the analysis mode, derives the particle size d of the target particle from the mean-square displacement Δ MS of the bright point of the target particle based on the mean-square displacement Δ MS-cal of the bright point of the calibration particle and the particle size d cal of the calibration particle.

公开(公告)号：EP3611492A1

公开(公告)日：2020-02-19

申请号：EP18783731.5

申请日：2018-03-30

申请人： Rion Co., Ltd. ,  National Institute Of Advanced Industrial Science

发明人： KONDO, Kaoru ,  TABUCHI, Takuya ,  BANDO, Kazuna ,  KATO, Haruhisa ,  MATSUURA, Yusuke

IPC分类号： G01N15/02 ,  G01N21/05 ,  G01P3/36

摘要： Provided is a particle measuring device and a particle measuring method for measuring a particle size with favorable accuracy. A flow cell (1) includes a flow passage (1a) of sample fluid. An irradiation optical system (3) irradiates, with light from a light source (2), the sample fluid in the flow passage (1a). An imaging unit (4) captures, from an extension direction of the flow passage (1a), an image of scattered light from the particle in a detection region in the flow passage (1a), the light passing through the detection region. A particle size specifying unit specifies a movement amount of the particle in a two-dimensional direction by Brownian motion based on multiple still images of a particle image captured at a predetermined frame rate by the imaging unit (4), thereby specifying the particle size of the particle from the movement amount in the two-dimensional direction.