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公开(公告)号：EP3862742A1
公开(公告)日：2021-08-11
申请号：EP19869892.0
申请日：2019-09-30
申请人： NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY , RION Co., Ltd. , Kioxia Corporation
发明人： KATO, Haruhisa , MATSUURA, Yusuke , NAKAMURA, Ayako , KONDO, Kaoru , TABUCHI, Takuya , TOMITA, Hiroshi , HAYASHI, Hidekazu
摘要： To easily calibrate, using a calibration particle, a measuring device configured to capture an image of a target object such as a target particle. An image analyzer (21) acquires multiple images obtained at a predetermined time interval Δt, (a) specifies the mean-square displacement Δ MS-cal of a bright point of a calibration particle based on the displacement, in terms of a pixel unit, of the bright point of the calibration particle in the multiple images in a calibration mode, and (b) specifies the mean-square displacement Δ MS of a bright point of the target particle based on the displacement, in terms of the pixel unit, of the bright point of the target particle in the multiple images in a measuring mode. A particle size analyzer (22), (c) in the analysis mode, derives the particle size d of the target particle from the mean-square displacement Δ MS of the bright point of the target particle based on the mean-square displacement Δ MS-cal of the bright point of the calibration particle and the particle size d cal of the calibration particle.
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公开(公告)号：EP3611492A1
公开(公告)日：2020-02-19
申请号：EP18783731.5
申请日：2018-03-30
摘要： Provided is a particle measuring device and a particle measuring method for measuring a particle size with favorable accuracy. A flow cell (1) includes a flow passage (1a) of sample fluid. An irradiation optical system (3) irradiates, with light from a light source (2), the sample fluid in the flow passage (1a). An imaging unit (4) captures, from an extension direction of the flow passage (1a), an image of scattered light from the particle in a detection region in the flow passage (1a), the light passing through the detection region. A particle size specifying unit specifies a movement amount of the particle in a two-dimensional direction by Brownian motion based on multiple still images of a particle image captured at a predetermined frame rate by the imaging unit (4), thereby specifying the particle size of the particle from the movement amount in the two-dimensional direction.
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公开(公告)号：EP4123289A1
公开(公告)日：2023-01-25
申请号：EP21770643.1
申请日：2021-03-03
申请人： RION Co., Ltd.
发明人： BANDO, Kazuna , KONDO, Kaoru , TABUCHI, Takuya , KONDO, Sota
摘要： In the present invention, irradiation light is radiated to a flow channel, and scattered light from particles included in a material passing through a detection region formed in a predetermined section is condensed at a position virtually extended in the flow direction of a sample and imaged at a predetermined frame rate. An amount of movement in the direction perpendicular to the flow direction of the particles due to Brownian motion is then calculated on the basis of a plurality of frame images. In order to correct an error in the amount of movement on an image, caused by magnification in a defocus position, the amount of movement is corrected using a correction value determined in advance, and the diameter of the particles is specified.
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公开(公告)号：EP4083604A1
公开(公告)日：2022-11-02
申请号：EP20906454.2
申请日：2020-12-17
申请人： RION Co., Ltd.
发明人： KONDO, Kaoru , BANDO, Kazuna , TABUCHI, Takuya , KONDO, Sota
摘要： Provided is a particle measurement device in which irradiation light emitted by a light source is expanded by an expander in a shape satisfying the requirements of a diffractive optical element, converted into parallel light, and made to enter the diffractive optical element. The diffractive optical element shapes the irradiation light entering therein into a flat top beam in which the cross section in the focal position thereof has an elongate rectangle shape. The intensity distribution of light can be made substantially uniform in a detection area formed by the shaped irradiation light.
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