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1.发明公开ALKYL AMINES IMPROVE DETECTION OF COMPONENTS OF FORMALDEHYDE-FIXED BIOLOGICAL SAMPLES 有权烷基胺用于生物样品甲醛固定成分的改进的检测
公开(公告)号：EP2132549A1
公开(公告)日：2009-12-16
申请号：EP08734758.9
申请日：2008-03-26
CPC分类号： G01N1/30 , C12Q1/6806 , C12Q2523/101
摘要： Alkyl amines act to release formaldehyde cross-linking that occurs in biological samples. Thus, contacting alkyl amines to formaldehyde fixed samples is a useful way to render biological components of the samples, including nucleic acids or proteins, more accessible to detection and characterization.
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公开(公告)号：EP2598653B1
公开(公告)日：2017-08-23
申请号：EP11735890.3
申请日：2011-07-27
发明人： EICKHOFF, Meike , HITZIGER, Niclas , ZIMMERMANN, Dirk , MYERS, Thomas, W. , WILL, Stephen, Gordon , SMITH, Edward, S. , WILTS, Heike , MUSSMANN, Anke , NEWHOUSE, Christopher , NEWTON, Nicolas , NIEMIEC, John, T. , SCHOENBRUNNER, Nancy
CPC分类号： C12Q1/6888 , B01L3/00 , B01L3/50851 , C12Q1/6844 , C12Q1/701 , C12Q2537/101 , C12Q2537/143
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公开(公告)号：EP2598656B1
公开(公告)日：2017-07-12
申请号：EP11738216.8
申请日：2011-07-27
发明人： EICKHOFF, Meike , HITZIGER, Niclas , ZIMMERMANN, Dirk , WILL, Stephen, Gordon , FISS, Ellen, H. , GLAUBITZ, Joachim
CPC分类号： C12Q1/6888 , C12Q1/701 , C12Q2531/113 , C12Q2537/143 , C12Q2545/101 , C12Q2563/149
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公开(公告)号：EP2337865A1
公开(公告)日：2011-06-29
申请号：EP09740853.8
申请日：2009-10-17
CPC分类号： C12Q1/6858 , C12Q2535/125 , C12Q2525/117
摘要： The present invention includes a method of allele-specific amplification, utilizing an allele-specific oligonucleotide, at least partially complementary to more than one variant of the target sequence, having a 3'-terminal nucleotide complementary to only one variant of the target sequence and having at least one nucleotide with a base covalently modified at the exocyclic amino group, wherein the allele-specific oligonucleotide is extended by a nucleotide-incorporating biocatalyst predominantly when hybridized to the variant of the target sequence for which it has said complementary 3'-terminal nucleotide.
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5.发明授权
公开(公告)号：EP2337865B1
公开(公告)日：2014-11-19
申请号：EP09740853.8
申请日：2009-10-17
CPC分类号： C12Q1/6858 , C12Q2535/125 , C12Q2525/117
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6.发明公开DETECTION OF TARGET VARIANTS USING A FLUORESCENT LABELAND AND A SOLUBLE QUENCHER 有权NUCLEIC变分原理用荧光标记和可溶性淬灭剂检测
公开(公告)号：EP2347012A1
公开(公告)日：2011-07-27
申请号：EP09778549.7
申请日：2009-09-16
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C12Q2563/173 , C12Q2527/107
摘要： Methods, reaction mixtures and kits for detecting the presence or absence of a target nucleic acid variant from a selection of possible variants is described.
摘要翻译： 方法中，反应混合物和系统，用于从选择的可能的变体检测靶核酸变体的存在或不存在下进行说明。
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7.发明授权DETECTION OF TARGET VARIANTS USING A FLUORESCENT LABEL AND A SOLUBLE QUENCHER 有权NUCLEIC变分原理用荧光标记和可溶性淬灭剂检测
公开(公告)号：EP2347012B1
公开(公告)日：2017-04-19
申请号：EP09778549.7
申请日：2009-09-16
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C12Q2563/173 , C12Q2527/107
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8.发明授权ALKYL AMINES IMPROVE DETECTION OF COMPONENTS OF FORMALDEHYDE-FIXED BIOLOGICAL SAMPLES 有权烷基胺用于生物样品甲醛固定成分的改进的检测
公开(公告)号：EP2132549B1
公开(公告)日：2013-09-11
申请号：EP08734758.9
申请日：2008-03-26
CPC分类号： G01N1/30 , C12Q1/6806 , C12Q2523/101
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公开(公告)号：EP2598653A1
公开(公告)日：2013-06-05
申请号：EP11735890.3
申请日：2011-07-27
发明人： EICKHOFF, Meike , HITZIGER, Niclas , ZIMMERMANN, Dirk , MYERS, Thomas, W. , WILL, Stephen, Gordon , SMITH, Edward, S. , WILTS, Heike , MUSSMANN, Anke , NEWHOUSE, Christopher , NEWTON, Nicolas , NIEMIEC, John, T. , SCHOENBRUNNER, Nancy
CPC分类号： C12Q1/6888 , B01L3/00 , B01L3/50851 , C12Q1/6844 , C12Q1/701 , C12Q2537/101 , C12Q2537/143
摘要： The present invention provides a method for the amplification of at least a first and a second target nucleic acid that may be present in a fluid sample. The invention further provides a kit and an analytical system for carrying out said amplification.
摘要翻译： 本发明提供了扩增可能存在于流体样品中的至少第一和第二靶核酸的方法。 本发明还提供了用于进行所述扩增的试剂盒和分析系统。
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公开(公告)号：EP2598656A1
公开(公告)日：2013-06-05
申请号：EP11738216.8
申请日：2011-07-27
发明人： EICKHOFF, Meike , HITZIGER, Niclas , ZIMMERMANN, Dirk , WILL, Stephen, Gordon , FISS, Ellen, H. , GLAUBITZ, Joachim
CPC分类号： C12Q1/6888 , C12Q1/701 , C12Q2531/113 , C12Q2537/143 , C12Q2545/101 , C12Q2563/149
摘要： The present invention concerns the amplification of at least a first and a second target nucleic acid that may be present in at least one fluid sample using an internal control nucleic acid for qualitative and/or quantitative purposes.
摘要翻译： 本发明涉及至少第一和第二靶核酸的扩增，其可以使用内部对照核酸存在于至少一种流体样品中，用于定性和/或定量目的。
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