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公开(公告)号：EP1641943B1
公开(公告)日：2013-03-20
申请号：EP04756455.4
申请日：2004-06-29
发明人： GELFAND, David, H. , REICHERT, Fred, L. , BODEPUDI, Veeraiah , GUPTA, Amar , WILL, Stephen, G. , MYERS, Thomas, B.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , Y10S435/975 , C12Q2535/101 , C12Q2525/101 , C12Q2525/186
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2.发明授权ALKYL AMINES IMPROVE DETECTION OF COMPONENTS OF FORMALDEHYDE-FIXED BIOLOGICAL SAMPLES 有权烷基胺用于生物样品甲醛固定成分的改进的检测
公开(公告)号：EP2132549B1
公开(公告)日：2013-09-11
申请号：EP08734758.9
申请日：2008-03-26
CPC分类号： G01N1/30 , C12Q1/6806 , C12Q2523/101
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公开(公告)号：EP2076606B1
公开(公告)日：2012-01-25
申请号：EP07819065.9
申请日：2007-10-17
IPC分类号： C12Q1/68
CPC分类号： C12P19/34 , C12Q1/6827 , C12Q1/6848 , C12Q1/6886 , C12Q2600/156 , C12Q2565/301 , C12Q2525/186 , C12Q2521/101
摘要： The present invention provides reaction mixtures that include blocked oligonucleotides comprising 2'-terminator nucleotides. The blocked oligonucleotides are rendered extendible when the 2'-terminator nucleotides are removed from the oligonucleotides, e.g., via pyrophosphorolysis. The reaction mixtures can be used in various nucleic acid polymerization and/or amplification assays, among many other applications. In addition to reaction mixtures, the invention also provides related methods and reaction mixtures.
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公开(公告)号：EP1644394B1
公开(公告)日：2018-05-09
申请号：EP04809468.4
申请日：2004-06-29
CPC分类号： C07H21/04 , C07H19/00 , C07H19/16 , C12Q1/6869
摘要： The invention provides compositions that comprise nucleotides and/or nucleosides having blocking groups at 2′-positions of sugar moieties. Methods of synthesizing these nucleic acids are also provided.
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公开(公告)号：EP1565480B1
公开(公告)日：2018-08-22
申请号：EP03785650.7
申请日：2003-11-20
发明人： BODEPUDI, Veeraiah , GUPTA, Amar , WILL, Stephen
IPC分类号： C07H19/052 , C07H21/00 , C12Q1/68 , G01N33/53
CPC分类号： C07H21/00 , C07H19/052 , C07H19/067 , C12Q1/34 , G01N33/533
摘要： The invention relates to detectable labels useful for detection of nucleotide sequences. Specifically, the invention relates to labeled-imidazole-PEG compounds, such as nucleosides, nucleotides, and nucleic acids incorporating such compounds, and methods utilizing such compounds. The invention further relates to kits comprising labeled imidazole-PEG compounds.
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公开(公告)号：EP2758546B1
公开(公告)日：2017-11-22
申请号：EP12770415.3
申请日：2012-09-12
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , C12Q2525/117 , C12Q2535/125
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7.发明公开SYNTHESIS AND COMPOSITIONS OF NUCLEIC ACIDS COMPRISING 2'-TERMINATOR NUCLEOTIDES 审中-公开合成和核酸与'终止核苷酸组合物
公开(公告)号：EP2195327A2
公开(公告)日：2010-06-16
申请号：EP07819087.3
申请日：2007-10-18
CPC分类号： C12Q1/6827 , C07H21/00 , C07H21/04 , C12P19/34 , C12Q1/6848 , Y10S435/975 , C12Q2565/301 , C12Q2525/186 , C12Q2521/101
摘要： The invention provides methods of producing blocked oligonucleotides that include 2'-terminator nucleotides. These blocked oligonucleotides are used primers and probes in a variety of nucleic acid technologies. Related kits are also provided.
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8.发明公开ALKYL AMINES IMPROVE DETECTION OF COMPONENTS OF FORMALDEHYDE-FIXED BIOLOGICAL SAMPLES 有权烷基胺用于生物样品甲醛固定成分的改进的检测
公开(公告)号：EP2132549A1
公开(公告)日：2009-12-16
申请号：EP08734758.9
申请日：2008-03-26
CPC分类号： G01N1/30 , C12Q1/6806 , C12Q2523/101
摘要： Alkyl amines act to release formaldehyde cross-linking that occurs in biological samples. Thus, contacting alkyl amines to formaldehyde fixed samples is a useful way to render biological components of the samples, including nucleic acids or proteins, more accessible to detection and characterization.
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公开(公告)号：EP2076606A2
公开(公告)日：2009-07-08
申请号：EP07819065.9
申请日：2007-10-17
IPC分类号： C12Q1/68
CPC分类号： C12P19/34 , C12Q1/6827 , C12Q1/6848 , C12Q1/6886 , C12Q2600/156 , C12Q2565/301 , C12Q2525/186 , C12Q2521/101
摘要： The present invention provides reaction mixtures that include blocked oligonucleotides comprising 2'-terminator nucleotides. The blocked oligonucleotides are rendered extendible when the 2'-terminator nucleotides are removed from the oligonucleotides, e.g., via pyrophosphorolysis. The reaction mixtures can be used in various nucleic acid polymerization and/or amplification assays, among many other applications. In addition to reaction mixtures, the invention also provides related methods and reaction mixtures.
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公开(公告)号：EP2794916B1
公开(公告)日：2016-04-20
申请号：EP12812526.7
申请日：2012-12-18
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C07H21/04 , C12Q1/6848 , C12Q2525/117
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