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公开(公告)号：EP3083992A1
公开(公告)日：2016-10-26
申请号：EP14821146.9
申请日：2014-12-18
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/686 , C12Q2549/10 , C12Q2563/107
摘要： The present invention provides for methods and compositions that use fluorescent dyes for the identification of reagents and solutions that are used to perform PCR assays.
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2.发明公开PREFERENTIAL AMPLIFICATION OF MRNA OVER DNA USING CHEMICALLY MODIFIED PRIMERS 有权mRNA的优选的扩增DNA关于使用化学修饰的引物
公开(公告)号：EP2510118A2
公开(公告)日：2012-10-17
申请号：EP10795943.9
申请日：2010-12-10
发明人： STEINER, Lori , TSAN, Alison , WILL, Stephen G. , NEWTON, Nicolas
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6848 , C12Q1/686 , C12Q2539/105 , C12Q2525/117 , C12Q2521/107
摘要： The present invention relates to a method, oligonucleotides, reaction mixtures and a kits for the selective amplification of a messenger RNA target comprising an exon-exon junction, using a oligonucleotide that comprises at least one nucleotide modified at the exocyclic amino group.
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3.发明公开METHOD OF DETERMINING THE FRACTION OF FETAL DNA IN MATERNAL BLOOD USING HLA MARKERS 审中-公开PROCEDURE测定胎儿DNA母体血液的共享HLA-MARKERS
公开(公告)号：EP2994538A1
公开(公告)日：2016-03-16
申请号：EP14722211.1
申请日：2014-05-07
发明人： ERLICH, Henry A. , HOGLUND, Bryan , HOLCOMB, Cherie , MOONSAMY, Priscilla , NEWTON, Nicolas , RASTROU, Melinda , TSAN, Alison , SCHOENBRUNNER, Nancy
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172
摘要： The invention comprises a method of determining the fraction of fetal DNA in maternal blood or plasma using HLA locus wherein the maternal and fetal HLA alleles are detected and quantified by clonal or digital methods.
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4.发明授权PREFERENTIAL AMPLIFICATION OF MRNA OVER DNA USING CHEMICALLY MODIFIED PRIMERS 有权mRNA的优选的扩增DNA关于使用化学修饰的引物
公开(公告)号：EP2510118B1
公开(公告)日：2013-10-09
申请号：EP10795943.9
申请日：2010-12-10
发明人： STEINER, Lori , TSAN, Alison , WILL, Stephen G. , NEWTON, Nicolas
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6848 , C12Q1/686 , C12Q2539/105 , C12Q2525/117 , C12Q2521/107
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5.发明公开NON-INVASIVE EARLY DETECTION OF SOLID ORGAN TRANSPLANT REJECTION BY QUANTITATIVE ANALYSIS OF MIXTURES BY DEEP SEQUENCING OF HLA GENE AMPLICONS USING NEXT GENERATION SYSTEMS 审中-公开移植固体的无创的早期检测BY BY混合体HLA-GEN组的深度测序的定量分析手段扩增子系统的下一代BASIS
公开(公告)号：EP2994539A1
公开(公告)日：2016-03-16
申请号：EP14722660.9
申请日：2014-05-07
发明人： ERLICH, Henry, A. , HOGLUND, Bryan , HOLCOMB, Cherie , MOONSAMY, Priscilla , NEWTON, Nicolas , RASTROU, Melinda , SALOMON, Daniel, R. , SCHOENBRUNNER, Nancy , TSAN, Alison
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/118
摘要： The invention is a method of detecting or assessing solid organ graft (transplant) rejection by detecting donor-specific HLA alleles in a blood sample of a graft (transplant) recipient. The invention further comprises a method of detecting the presence of maternal cells in a blood sample of an offspring.
摘要翻译： 本发明是检测或通过接枝（移植）接受者的血液样品中检测的供体特异性的HLA等位基因assesing实体器官移植物（移植）排斥的方法。 本发明还包括检测后代的血液样品中的母体细胞的存在的方法。
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公开(公告)号：EP2510117B1
公开(公告)日：2014-12-10
申请号：EP10795240.0
申请日：2010-12-10
发明人： TSAN, Alison , NEWTON, Nicolas , WILL, Stephen, G.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q1/6886 , C12Q2600/156 , C12Q2600/166 , C12Q2525/185 , C12Q2525/117
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公开(公告)号：EP2510117A1
公开(公告)日：2012-10-17
申请号：EP10795240.0
申请日：2010-12-10
发明人： TSAN, Alison , NEWTON, Nicolas , WILL, Stephen, G.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q1/6886 , C12Q2600/156 , C12Q2600/166 , C12Q2525/185 , C12Q2525/117
摘要： The present invention includes a method of allele-specific amplification, utilizing an allele-specific oligonucleotide, at least partially complementary to more than one variant of the target sequence, having an internally-placed selective nucleotide complementary to only one variant of the target sequence wherein the allele-specific oligonucleotide is extended by a nucleic acid polymerase predominantly or exclusively when hybridized to the variant of the target sequence for which it has said complementary selective nucleotide.
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公开(公告)号：EP2839039A1
公开(公告)日：2015-02-25
申请号：EP13716295.4
申请日：2013-04-15
发明人： LEYING, Hermann , MYERS, Thomas W. , NEWTON, Nicolas , RUSSMANN, Eberhard , SAN FILIPPO, Joseph , SCHOENBRUNNER, Nancy , WILTS, Heike , WU, Xiaoning , YOUNG, Karen Kwok Ying , ZIMMERMANN, Dirk
IPC分类号： C12Q1/70
CPC分类号： C12Q1/707 , C12Q2600/16
摘要： A method of simultaneously amplifying genotypes 1, 2, 3 and/or 4 of HEV is disclosed comprising amplifying the genotypes 1, 2, 3 and/or 4 of HEV with one single non-degenerate forward primer partially overlapping the 5'UTR region of HEV and at least one reverse primer.
摘要翻译： 公开了一种同时扩增HEV的基因型1,2,3和/或4的方法，包括用一个单一的非简并正向引物扩增HEV的基因型1,2,3和/或4，所述单一非简并正向引物部分重叠 HEV和至少一个反向引物。
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公开(公告)号：EP2598653A1
公开(公告)日：2013-06-05
申请号：EP11735890.3
申请日：2011-07-27
发明人： EICKHOFF, Meike , HITZIGER, Niclas , ZIMMERMANN, Dirk , MYERS, Thomas, W. , WILL, Stephen, Gordon , SMITH, Edward, S. , WILTS, Heike , MUSSMANN, Anke , NEWHOUSE, Christopher , NEWTON, Nicolas , NIEMIEC, John, T. , SCHOENBRUNNER, Nancy
CPC分类号： C12Q1/6888 , B01L3/00 , B01L3/50851 , C12Q1/6844 , C12Q1/701 , C12Q2537/101 , C12Q2537/143
摘要： The present invention provides a method for the amplification of at least a first and a second target nucleic acid that may be present in a fluid sample. The invention further provides a kit and an analytical system for carrying out said amplification.
摘要翻译： 本发明提供了扩增可能存在于流体样品中的至少第一和第二靶核酸的方法。 本发明还提供了用于进行所述扩增的试剂盒和分析系统。
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公开(公告)号：EP2379741B1
公开(公告)日：2016-03-23
申请号：EP09795713.8
申请日：2009-12-17
发明人： NEWTON, Nicolas
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C12Q2565/101 , C12Q2527/107
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