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1.发明公开PHARMACEUTICAL COMPOSITIONS WHICH INHIBIT PROLIFERATION OF PITUITARY ADENOMAS AND METHOD OF USE THEREOF 审中-公开药物组合物用于抑制垂体腺瘤的使用增殖和方法
公开(公告)号：EP1399179A2
公开(公告)日：2004-03-24
申请号：EP02746655.6
申请日：2002-06-25
申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S. , Il Consorzio Ferrara Richerche
IPC分类号： A61K38/31 , A61K38/08 , A61K38/12 , A61K38/18 , C07K7/02 , C07K7/04 , C07K7/06 , C07K7/08 , C07K14/655
CPC分类号： A61K38/31
摘要： The present invention is directed to a method of reducing the rate of proliferation of adenoma cells which method comprises contacting said pituitary adenoma cells with one or more of an SSTR1 agonist, and/or one or more of an SSTR2 agonist, and/or one or more of SSTR5 agonist, or one or more pharmaceutically acceptable salts thereof, either alone or in combination.
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公开(公告)号：EP1446137A2
公开(公告)日：2004-08-18
申请号：EP02795671.3
申请日：2002-11-21
IPC分类号： A61K38/00
CPC分类号： C07K14/6555 , A61K38/00
摘要： Claimed is a somatostatin agonist according to the formula (I): D-Phe-c(Cys-Tyr(I)-D-Trp-Lys-Val-Cys)-Thr-NH2, or a pharmaceutically acceptable salt thereof, and uses thereof.
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公开(公告)号：EP1401863A1
公开(公告)日：2004-03-31
申请号：EP02734699.8
申请日：2002-06-07
IPC分类号： C07K7/00
CPC分类号： C07D471/04 , A61K38/00 , C07D471/06 , C07K14/6555
摘要： Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is : 6-n-propyl-8β-ergolinglmethylthioacetyl-D-Phe-c-(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH¿2?
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