公开(公告)号：EP1097150A1

公开(公告)日：2001-05-09

申请号：EP99931792.8

申请日：1999-06-11

申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： DONG, Zheng, Xin ,  SHEN, Yeelana

IPC分类号： C07D403/06 ,  C07D403/14 ,  C07D417/14 ,  A61K31/415 ,  A61P35/00

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D403/14

摘要： The present invention is directed to imidazolyl derivatives of formula (II), wherein the variables are defined in the specification, which are useful as prenyl transferase inhibitors.

公开(公告)号：EP1137667A2

公开(公告)日：2001-10-04

申请号：EP99963437.1

申请日：1999-12-07

申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： DONG, Zheng, Xin

IPC分类号： C07K14/605 ,  A61K38/26

CPC分类号： C07K14/605 ,  A61K38/00

摘要： The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues.

公开(公告)号：EP1401863A1

公开(公告)日：2004-03-31

申请号：EP02734699.8

申请日：2002-06-07

申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： CULLER, Michael, D. ,  DONG, Zheng, Xin ,  KIM, Sun, H. ,  MOREAU, Jacques-Pierre

IPC分类号： C07K7/00

CPC分类号： C07D471/04 ,  A61K38/00 ,  C07D471/06 ,  C07K14/6555

摘要： Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is : 6-n-propyl-8β-ergolinglmethylthioacetyl-D-Phe-c-(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH¿2?

公开(公告)号：EP1542716A1

公开(公告)日：2005-06-22

申请号：EP03785034.4

申请日：2003-08-08

申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： DONG, Zheng, Xin

IPC分类号： A61K38/40

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K5/0205 ,  C07K5/06034 ,  C07K5/1016 ,  C07K5/1024 ,  C07K7/02 ,  C07K14/60

摘要： Disclosed are peptide and peptidomimetic compounds generally according to formula (I), and pharmaceutically acceptable salts thereof, that are useful as GHRP analogs: R1-A2-A3-A4-A5-R2 (I) or a pharmaceutically acceptable salt thereof, wherein: A1 is Aib, Apc or Inp; A2 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Na1, D-Ser(Bzl), or D-Trp; A3 is D-Bal, D-Bip, D-Bpa, D-Dip, D-1Nal, D-2Nal, D-Ser(Bzl), or D-Trp; A4 is 2Fua, Orn, 2Pa1, 3Pal, 4Pa1, Pff, Phe, Pim, Taz, 2Thi, 3Thi, Thr(Bzl); A5 is Apc, Dab, Dap, Lys, Orn, or deleted; R1 is hydrogen, (C1-6)alkyl, (C5-14)aryl, (C1-6)alkyl(C5-14)aryl, (C3-8)cycloakyl, or (C2-10)acyl; and R2 is OH or NH2; and pharmaceutical compositions and methods of use thereof.

公开(公告)号：EP1137666A1

公开(公告)日：2001-10-04

申请号：EP99960657.7

申请日：1999-12-07

申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S. ,  The Administrators ofThe Tulane Educational Fund

发明人： DONG, Zheng, Xin ,  COY, David, H.

IPC分类号： C07K14/605 ,  A61K38/26 ,  A61P3/08

CPC分类号： C07K14/605 ,  A61K38/00 ,  Y02P20/55

摘要： The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues.