公开(公告)号：EP1539171A2

公开(公告)日：2005-06-15

申请号：EP03771925.9

申请日：2003-07-29

申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： SCHROFF, Robert, W.

IPC分类号： A61K31/505

CPC分类号： A61K31/195 ,  A61K31/00 ,  A61K31/196 ,  A61K31/513

摘要： Disclosed is a method of treating A-V graft failure in a subject in need of such treatment, said method comprising administering to said subject an effective amount of an agent that inhibits the production, release or neo-intima generating effects of chymase, wherein said effective amount of said agent is an amount effective to treat said A-V graft failure.

公开(公告)号：EP1355940A2

公开(公告)日：2003-10-29

申请号：EP01987763.8

申请日：2001-10-19

申请人： The Administrators ofThe Tulane Educational Fund ,  SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： COY, David, H. ,  ROSSOWSKI, Wojciech, J. ,  TAYLOR, John, E.

IPC分类号： C07K14/575 ,  A61K38/22

CPC分类号： C07K7/52 ,  A61K38/00 ,  C07K14/57509

摘要： The present invention features a novel class of cyclic polypeptides that have U-II antagonist and agonist activity. The invention also features methods for treating physiological or psychological conditions characterized by an excess or under expression of Ur4otensin-II.

公开(公告)号：EP1189939A1

公开(公告)日：2002-03-27

申请号：EP00943091.9

申请日：2000-06-23

申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： MORGAN, Barry, A. ,  PREVOST, Gregoire ,  COTTER, Thomas, G. ,  FINNEGAN, Nicola

IPC分类号： C07K14/47 ,  A61P35/00

CPC分类号： C07K14/4747 ,  A61K38/00

摘要： The present invention is directed to a peptide of formula (I), as defined herein, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising said peptide of formula (I), and the use thereof to restore apoptosis in human tumor cells. A compound of formula (I) of the present invention is R-A?1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-NHR1¿ or a pharmaceutically acceptable salt thereof wherein, R is (C¿1?-C5)acyl; A?1¿ is absent or an aliphatic amino acid; A2 is absent or is selected from the group consisting of Gly, Ala, Ser, Thr and Asn; A?3 and A4¿ are each absent or are each a coded amino acid; A5 is an aliphatic amino acid; A6 is Ala or a basic amino acid; A7 is selected from the group consisting of Ile, Leu, Val, Ser, Thr, Lys and Arg; A8 is an aliphatic amino acid; A9 is Gly; A?10 and A11¿ are each independently Asp or Glu; A12 is an aliphatic amino acid Ile, Leu, Met and Val; A13 is Asp, Glu or Asn; A?14 and A15¿ are each independently absent or selected from the group consisting of Ile, Leu, Val, Met, Ser, Thr, Asn, Lys and Arg; and R1 is (C¿1?-C5)alkyl.

公开(公告)号：EP1098906A1

公开(公告)日：2001-05-16

申请号：EP99920844.0

申请日：1999-04-30

申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： DONG, Zheng, X.

IPC分类号： C07K14/575 ,  A61K38/22

CPC分类号： C07K14/57563 ,  A61K38/00

摘要： The present invention is directed to novel analogues of PACAP (Pituitary Adenylate Cyclase Activating Polypeptide) as described in the specification, which are agonist of the PACAP receptor and as such are useful in treating cerebrovascular ischemia, male impotence, motor neuron disease, neuropathy, pain, depression, anxiety disorders, brain trauma, memory impairments, dementia, cognitive disorder, central nervous system diseases (such as Parkinson's disease, Alzheimer's disease), migraine, neurodegenerative diseases, ischemic heart disease, myocardial infarction, fibrosis, restenosis, diabetes mellitus, muscle disease, gastric ulcer, stroke, atherosclerosis, hypertension, septic shock, thrombosis, retina disease, cardiovascular disease, renal failure and cardiac failure and the prevention of neuronal cell death in a mammal. This invention is also directed to pharmaceutical compositions useful therefor.

公开(公告)号：EP1097150A1

公开(公告)日：2001-05-09

申请号：EP99931792.8

申请日：1999-06-11

申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： DONG, Zheng, Xin ,  SHEN, Yeelana

IPC分类号： C07D403/06 ,  C07D403/14 ,  C07D417/14 ,  A61K31/415 ,  A61P35/00

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D403/14

摘要： The present invention is directed to imidazolyl derivatives of formula (II), wherein the variables are defined in the specification, which are useful as prenyl transferase inhibitors.

公开(公告)号：EP1086101A1

公开(公告)日：2001-03-28

申请号：EP99928479.7

申请日：1999-06-08

申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： THURIEAU, Christophe, Alain ,  POITOUT, Lydie, Francine ,  GALCERA, Marie-Odile ,  MOINET, Christophe, Philippe ,  GORDON, Thomas, D. ,  MORGAN, Barry, A. ,  BIGG, Dennis, C., H. ,  POMMIER, Jacques

IPC分类号： C07D471/04 ,  A61K31/44 ,  C07D471/20 ,  C07D471/10 ,  C07D495/04

CPC分类号： C07D471/04 ,  C07D471/10 ,  C07D495/04

摘要： The present invention is directed to compounds of formula (I) wherein the variables are defined in the specification, which bind to somatostatin receptors and block Na channels.

摘要翻译： 本发明涉及式（I）化合物，其中变量在说明书中定义，其与生长抑素受体结合并阻断Na通道。

公开(公告)号：EP1086086A1

公开(公告)日：2001-03-28

申请号：EP99927323.8

申请日：1999-06-08

申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： THURIEAU, Christophe, Alain ,  POITOUT, Lydie, Francine ,  GALCERA, Marie-Odile ,  GORDON, Thomas, D. ,  MORGAN, Barry ,  MOINET, Christophe, Philippe

IPC分类号： C07D233/00

CPC分类号： C07D233/64 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/14

摘要： The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors.

公开(公告)号：EP1399179A2

公开(公告)日：2004-03-24

申请号：EP02746655.6

申请日：2002-06-25

申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S. ,  Il Consorzio Ferrara Richerche

发明人： CULLER, Michael, D. ,  DEGLIUBERTI, Ettore, C. ,  ZATELLI, Maria, C.

IPC分类号： A61K38/31 ,  A61K38/08 ,  A61K38/12 ,  A61K38/18 ,  C07K7/02 ,  C07K7/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/655

CPC分类号： A61K38/31

摘要： The present invention is directed to a method of reducing the rate of proliferation of adenoma cells which method comprises contacting said pituitary adenoma cells with one or more of an SSTR1 agonist, and/or one or more of an SSTR2 agonist, and/or one or more of SSTR5 agonist, or one or more pharmaceutically acceptable salts thereof, either alone or in combination.

公开(公告)号：EP1075273A2

公开(公告)日：2001-02-14

申请号：EP99922851.3

申请日：1999-05-06

申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S. ,  Kaneko, Hiroshi ,  Mitsuma, Terunori ,  Yamashita, Koichi

发明人： KANEKO, Hiroshi ,  MITSUMA, Terunori ,  YAMASHITA, Koichi ,  MORGAN, Barry

IPC分类号： A61K38/31

CPC分类号： A61K38/31

摘要： The present invention is directed to a method of using somatostatin or a somatostatin agonist to inhibit the proliferation of Helicobacter pylori (H.pylori), which comprises administering to a patient in need thereof an effective amount of said somatostatin or somatostatin agonist. Preferably, a somatostatin sub-type receptor 2 (SSTR-2) selective somatostatin agonist is administered in a method of this invention. The inhibition of H.pylori proliferation is useful in treating various gastroduodenal diseases such as peptic ulcers, gastric cancer and gastric lymphoma.

公开(公告)号：EP1542691A2

公开(公告)日：2005-06-22

申请号：EP03758540.3

申请日：2003-09-29

申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S. ,  CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： PREVOST, Gregoire ,  BUSSON, Pierre ,  VICAT, Jean-Michel

IPC分类号： A61K31/4985 ,  A61K31/5517 ,  A61P35/00

CPC分类号： A61K31/4985 ,  A61K31/5517 ,  A61K2300/00

摘要： Disclosed is a novel drug combination which is useful for the treatment of nasopharyngeal carcinoma, said novel drug combination comprising one or more of a farnesyl transferase inhibitor and one or more of an anthracyline.