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    METABOLITE OF XANTHINE PHOSPHODIESTERASE 5 INHIBITOR AND DERIVATIVES THEREOF USEFUL FOR TREATMENT OF ERECTILE DYSFUNCTION
    1.
    发明公开
    METABOLITE OF XANTHINE PHOSPHODIESTERASE 5 INHIBITOR AND DERIVATIVES THEREOF USEFUL FOR TREATMENT OF ERECTILE DYSFUNCTION 有权
    代谢物XANTHINPHOSPHODIESTERASE-5抑制剂及其衍生物，导致SUITABLE勃起问题的治疗

    公开(公告)号：EP1648895A1

    公开(公告)日：2006-04-26

    申请号：EP04779540.6

    申请日：2004-07-29

    申请人： SCHERING CORPORATION

    发明人： GHOSAL, Anima ,  TONG, Wei ,  CHOWDHURY, Swapan, K. ,  ZBAIDA, Shmuel ,  WIRTH, Mark, A. ,  ALTON, Kevin, B. ,  PATRICK, James, E. ,  BOYLE, Craig, D. ,  STAMFORD, Andrew

    IPC分类号： C07D473/06 ,  A61K31/522

    CPC分类号： C07D473/06

    摘要： The present invention is directed to a metabolite of a xanthine Phosphodiesterase type 5 inhibitor having the following structure derivatives, and formulations thereof, and processes for preparing the same. Further disclosed are methods of treating a physiological disorder, symptom or disease in a patient, comprising administering to the patient an effective amount of the above compound, wherein the physiological disorder, symptom or disease is a urogenital, cardiovascular, cerebrovascular or peripheral vascular disorder, angina pectoris, hypertension, restenosis post angioplasty, endarterectomy, stent introduction, cerebral stroke, a respiratory tract disorder such as an allergic condition associated with atopy, pulmonary hypertension, an ischemic heart disorder, impaired glucose tolerance, diabetes and its related complication, insulin resistance syndrome, hyperglycemia, polycystic ovarian syndrome, a glomerular disorder, renal insufficiency, nephritis, a tubular interstitial disorder, an autoimmune disorder, glaucoma, intestinal motility, cachexia or cancer.

    CCR5 ANTAGONISTS USEFUL FOR TREATING HIV
    2.
    发明公开
    CCR5 ANTAGONISTS USEFUL FOR TREATING HIV 审中-公开
    CCR5拮抗剂治疗艾滋病

    公开(公告)号：EP1996576A1

    公开(公告)日：2008-12-03

    申请号：EP07751608.6

    申请日：2007-02-22

    申请人： Schering Corporation

    发明人： RAMANATHAN, Ragulan ,  MILLER, Michael, W. ,  CHOWDHURY, Swapan, K. ,  ALTON, Kevin, B. ,  GROTZ, Diane ,  RINDGEN, Diane ,  TENDOLKAR, Amol

    IPC分类号： C07D401/14 ,  C07D403/06 ,  C07D409/14 ,  C07D417/14

    CPC分类号： C07D401/14 ,  C07D409/14

    摘要： In its many embodiments, the present invention provides a novel class of compounds of structural formula I [Chemical formula should be inserted here as it appears on abstract in paper form.] as inhibitors of the CCR5 receptors, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with CCR5 using such compounds or pharmaceutical compositions. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.

    METABOLITE OF XANTHINE PHOSPHODIESTERASE 5 INHIBITOR AND DERIVATIVES THEREOF USEFUL FOR TREATMENT OF ERECTILE DYSFUNCTION
    4.
    发明授权
    METABOLITE OF XANTHINE PHOSPHODIESTERASE 5 INHIBITOR AND DERIVATIVES THEREOF USEFUL FOR TREATMENT OF ERECTILE DYSFUNCTION 有权
    代谢物XANTHINPHOSPHODIESTERASE-5抑制剂及其衍生物，导致SUITABLE勃起问题的治疗

    公开(公告)号：EP1648895B1

    公开(公告)日：2007-05-30

    申请号：EP04779540.6

    申请日：2004-07-29

    申请人： SCHERING CORPORATION

    发明人： GHOSAL, Anima ,  TONG, Wei ,  CHOWDHURY, Swapan, K. ,  ZBAIDA, Shmuel ,  WIRTH, Mark, A. ,  ALTON, Kevin, B. ,  PATRICK, James, E. ,  BOYLE, Craig, D. ,  STAMFORD, Andrew

    IPC分类号： C07D473/06 ,  A61K31/522

    CPC分类号： C07D473/06

    摘要： The present invention is directed to a metabolite of a xanthine Phosphodiesterase type 5 inhibitor having the following structure derivatives, and formulations thereof, and processes for preparing the same. Further disclosed are methods of treating a physiological disorder, symptom or disease in a patient, comprising administering to the patient an effective amount of the above compound, wherein the physiological disorder, symptom or disease is a urogenital, cardiovascular, cerebrovascular or peripheral vascular disorder, angina pectoris, hypertension, restenosis post angioplasty, endarterectomy, stent introduction, cerebral stroke, a respiratory tract disorder such as an allergic condition associated with atopy, pulmonary hypertension, an ischemic heart disorder, impaired glucose tolerance, diabetes and its related complication, insulin resistance syndrome, hyperglycemia, polycystic ovarian syndrome, a glomerular disorder, renal insufficiency, nephritis, a tubular interstitial disorder, an autoimmune disorder, glaucoma, intestinal motility, cachexia or cancer.