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    PIPERIDINYL PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF CHEMOKINE RECEPTORS
    1.
    发明公开
    PIPERIDINYL PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF CHEMOKINE RECEPTORS 审中-公开
    作为趋化因子的抑制剂受体SUITABLE PIPERIDINYLPIPERIDINDERIVATE

    公开(公告)号：EP1858886A1

    公开(公告)日：2007-11-28

    申请号：EP06735563.6

    申请日：2006-02-21

    申请人： Schering Corporation

    发明人： COX, Kathleen ,  MCCOMBIE, Stuart ,  WESTON, Daniel ,  MILLER, Michael W. ,  CHAN, Tze-ming ,  FENG, Wenqing

    IPC分类号： C07D401/14 ,  A61K31/4545 ,  A61P31/18

    CPC分类号： C07D401/14

    摘要： In its many embodiments, the present invention provides a novel class of compounds of structural formula (IA) or (IB) where R1-R8 are as disclosed herein as inhibitors of the CCR5 receptors, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with CCR5 using such compounds or pharmaceutical compositions. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.

    PIPERIDINYL PIPERAZINE DERIVATIVES USEFUL AS INHIBITORS OF CHEMOKINE RECEPTORS
    2.
    发明公开
    PIPERIDINYL PIPERAZINE DERIVATIVES USEFUL AS INHIBITORS OF CHEMOKINE RECEPTORS 审中-公开
    作为趋化因子的抑制剂受体SUITABLE PIPERIDINYLPIPERAZINDERIVATE

    公开(公告)号：EP1858887A1

    公开(公告)日：2007-11-28

    申请号：EP06735837.4

    申请日：2006-02-21

    申请人： Schering Corporation

    发明人： CHAN, Tze-Ming ,  COX, Kathleen ,  FENG, Wenqing ,  MILLER, Michael, W. ,  WESTON, Daniel ,  MCCOMBIE, Stuart, W.

    IPC分类号： C07D401/14 ,  C07D401/06 ,  A61K31/496 ,  A61P31/18

    CPC分类号： C07D211/96 ,  C07D401/06 ,  C07D401/14

    摘要： In its many embodiments, the present invention provides a novel class of compounds of structural formula IA or IB where R1-R8 are as disclosed herein Formula (IA) or (IB) as inhibitors of the CCR5 receptors, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with CCR5 using such compounds or pharmaceutical compositions. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.