-
1.发明公开METABOLITES OF TRICYCLIC AMIDES USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND METHODS OF TREATMENT OF PROLIFERATIVE DISEASES 审中-公开三环酰胺的代谢物G蛋白功能适用，和方法的增殖性疾病的治疗抑制
公开(公告)号：EP1644359A2
公开(公告)日：2006-04-12
申请号：EP04755902.6
申请日：2004-06-23
申请人： SCHERING CORPORATION
发明人： CHOWDHURY, Swapan, K. , GHOSAL, Anima , IANNUCCI, Robert, M. , FENG, Wenqing , CHAN, Tze-Ming , ZBAIDA, Shmuel , ALTON, Kevin, B. , DOLL, Ronald, J. , MINOR, Keith, P.
IPC分类号： C07D401/14 , A61K31/4545 , A61P35/00
CPC分类号： C07D401/14
摘要： The present invention relates to metabolites of tricyclic amides, and structurally related compounds, represented by the structural formula (I) and pharmaceutically acceptable isomers, salts, solvates or esters of the compound of formula (I), wherein: R1 is selected from the group consisting of H and =O; R2-R5 can be the same or different, each being independently selected from the group consisting of H, -OH, halide, -NH2 and =O; and, the combination solid-dashed lines independently represent either single bonds or double bonds, wherein the number of combination solid-dashed lines that are double bonds is not greater than 2, and when 2, the double bonds are not adjacent, and when 0, one of R1-R5 is not H. Also disclosed are methods of treatment of proliferative diseases and methods for inhibiting the abnormal growth of cells, and for inhibiting farnesyl protein transferase using the novel compounds.
-
2.发明授权SUGAR-SUBSTITUTED 2-AZETIDINONES USEFUL AS HYPOCHOLESTEROLEMIC AGENTS 有权糖取代作为药物使用2 - 氮杂环丁酮HYPOCHOLESTERDENISCHE
公开(公告)号：EP1347987B1
公开(公告)日：2004-10-13
申请号：EP01991315.1
申请日：2001-12-17
申请人： Schering Corporation
发明人： GHOSAL, Anima , ZBAIDA, Shmuel , CHOWDHURY, Swapan, K. , IANNUCCI, Robert, M. , FENG, Wenqing , ALTON, Kevin, B. , PATRICK, James, E. , DAVIS, Harry, R.
摘要： Hypocholesterolemic sugar-substituted 2-azetidinone compounds of the formula: are disclosed, as well as a method of lowering cholesterol by administering said compounds, pharmaceutical compositions containing them, and the combination of a sugar-substituted 2-azetidinone cholesterol-lowering agent and a cholesterol biosynthesis inhibitor for the treatment and prevention of atherosclerosis.
-
3.发明公开SUGAR-SUBSTITUTED 2-AZETIDINONES USEFUL AS HYPOCHOLESTEROLEMIC AGENTS 有权糖取代作为药物使用2 - 氮杂环丁酮HYPOCHOLESTERDENISCHE
公开(公告)号：EP1347987A1
公开(公告)日：2003-10-01
申请号：EP01991315.1
申请日：2001-12-17
申请人： Schering Corporation
发明人： GHOSAL, Anima , ZBAIDA, Shmuel , CHOWDHURY, Swapan, K. , IANNUCCI, Robert, M. , FENG, Wenqing , ALTON, Kevin, B. , PATRICK, James, E. , DAVIS, Harry, R.
摘要： Hypocholesterolemic sugar-substituted 2-azetidinone compounds of the formula: are disclosed, as well as a method of lowering cholesterol by administering said compounds, pharmaceutical compositions containing them, and the combination of a sugar-substituted 2-azetidinone cholesterol-lowering agent and a cholesterol biosynthesis inhibitor for the treatment and prevention of atherosclerosis.
-
-
搜索结果
3 条记录 (耗时 0.011 秒)
