公开(公告)号：EP0514359B1

公开(公告)日：1995-09-13

申请号：EP92830224.9

申请日：1992-05-14

申请人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

发明人： Taglialatela, Giulio ,  Fanto', Nicola ,  Santaniello, Mosè ,  Cavazza, Claudio

IPC分类号： C07C237/12 ,  A61K31/22

CPC分类号： C07C279/14 ,  C07C237/12 ,  C07C237/22 ,  C07C275/16

公开(公告)号：EP0514359A3

公开(公告)日：1993-03-10

申请号：EP92830224.9

申请日：1992-05-14

申请人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

发明人： Taglialatela, Giulio ,  Fanto', Nicola ,  Santaniello, Mosè ,  Cavazza, Claudio

IPC分类号： C07C237/12 ,  A61K31/22

CPC分类号： C07C279/14 ,  C07C237/12 ,  C07C237/22 ,  C07C275/16

摘要： Amides of alkanoyl L-carnitines of general formula (1).

wherein R is a straight or branched alkanoyl group having from 2 to 8 carbon atoms selected from acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, hexanoyl, 1-methylbutyryl, t-butylacetyl, 2-ethylbutyryl, 3-methylvaleryl, 4-methylvaleryl, 2-ethylhexanoyl and 2-propylpentanoyl;
R' is the monovalent residue of a naturally occurring aminoacid selected from:
and X - is the anion of a pharmacologically acceptable acid are active in regenerating the nervous tissue, inhibiting neuronal degeneration, enhancing the processes of learning and memory and for the treatment of coma. Orally or parenterally administrable compositions in unit dosage form comprise between about 50 and about 500 mg of an amide of formula (1).

公开(公告)号：EP0514359A2

公开(公告)日：1992-11-19

申请号：EP92830224.9

申请日：1992-05-14

申请人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

发明人： Taglialatela, Giulio ,  Fanto', Nicola ,  Santaniello, Mosè ,  Cavazza, Claudio

IPC分类号： C07C237/12 ,  A61K31/22

CPC分类号： C07C279/14 ,  C07C237/12 ,  C07C237/22 ,  C07C275/16

摘要： Amides of alkanoyl L-carnitines of general formula (1).

wherein R is a straight or branched alkanoyl group having from 2 to 8 carbon atoms selected from acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, hexanoyl, 1-methylbutyryl, t-butylacetyl, 2-ethylbutyryl, 3-methylvaleryl, 4-methylvaleryl, 2-ethylhexanoyl and 2-propylpentanoyl;

R' is the monovalent residue of a naturally occurring aminoacid selected from:




and
X - is the anion of a pharmacologically acceptable acid are active in regenerating the nervous tissue, inhibiting neuronal degeneration, enhancing the processes of learning and memory and for the treatment of coma.

Orally or parenterally administrable compositions in unit dosage form comprise between about 50 and about 500 mg of an amide of formula (1).

摘要翻译： 通式的烷酰基L-肉毒碱的酰胺类（1）。 worin R是直链或支链烷酰基具有2至从乙酰基，丙酰基，丁酰基，异丁酰基，戊酰基，异戊酰基，己酰基选择8个碳原子基团，1-甲基丁酰基，叔丁基乙酰基，2-乙基丁，3-甲基戊酰基 ，4-甲基戊酰基，2-乙基己和2-丙基戊; R“是选自以下的天然存在的氨基酸的一价残基： 和X < - >是药理学上可接受的酸的阴离子活跃在再生神经组织，抑制性神经元变性，增强学习的处理 记忆和昏迷的治疗。 以单位剂量形式口服或肠胃外给药的组合物约50至约500毫克的式（1）的酰胺的之间包括。