公开(公告)号：EP1294901A2

公开(公告)日：2003-03-26

申请号：EP01933003.4

申请日：2001-05-04

申请人： Sugen, Inc. ,  PHARMACIA & UPJOHN COMPANY

发明人： PLOWMAN, Gregory, D. ,  WHYTE, David ,  SUDARSANAM, Sucha ,  MANNING, Gerard ,  CAENEPEEL, Sean ,  PAYNE, Vilia

IPC分类号： C12N15/57 ,  C12N9/64 ,  C07K16/40 ,  C12Q1/37 ,  C12Q1/68

CPC分类号： C12N9/6424 ,  C12Q1/37 ,  G01N2333/96433

摘要： The present invention relates to protease polypeptides, nucleotide sequences encoding the protease polypeptides, as well as various products and methods useful for the diagnosis and treatment of various protease-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the of PTK's and STK's have been identified and their protein structure predicted.

公开(公告)号：EP1278859A2

公开(公告)日：2003-01-29

申请号：EP01924901.0

申请日：2001-04-10

申请人： Sugen, Inc.

发明人： PLOWMAN, Gregory ,  WHYTE, David ,  MANNING, Gerard ,  SUDARSANAM, Sucha ,  MARTINEZ, Ricardo ,  CAENEPEEL, Sean

IPC分类号： C12N15/54 ,  C12N9/12 ,  C12N1/21 ,  C12N5/12 ,  C12Q1/48 ,  C07K16/40 ,  C12Q1/68 ,  A61K38/45

CPC分类号： C12N9/1205 ,  A61K38/00

摘要： The present invention relates to kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the of PTK's and STK's have been identified and their protein structure predicted.

摘要翻译： 本发明涉及激酶多肽，编码激酶多肽的核苷酸序列，以及可用于诊断和治疗各种激酶相关疾病和病症的各种产物和方法。 通过使用生物信息学策略，确定了PTK和STK的哺乳动物成员，并预测了其蛋白质结构。

公开(公告)号：EP1320614A2

公开(公告)日：2003-06-25

申请号：EP01950434.9

申请日：2001-06-26

申请人： Sugen, Inc.

发明人： PLOWMAN, Gregory ,  WHYTE, David ,  SUDARSANAM, Sucha ,  MANNING, Gerard ,  CAENEPEEL, Sean ,  CHARYDCZAK, Glen

IPC分类号： C12N15/55 ,  C12N9/64 ,  C07K16/40 ,  C12N5/10 ,  G01N33/50 ,  G01N33/53 ,  C12Q1/68

CPC分类号： C12N9/6421 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention relates to protease polypeptides, nucleotide sequences encoding the protease polypeptides, as well as various products and methods useful for the diagnosis and treatment of various protease-related diseases and conditions.

公开(公告)号：EP1297007A2

公开(公告)日：2003-04-02

申请号：EP01939611.8

申请日：2001-05-30

申请人： Sugen, Inc.

发明人： PLOWMAN, Gregory, D. ,  WHYTE, David ,  SUDARSANAM, Sucha ,  MANNING, Gerard ,  CAENEPEEL, Sean ,  MARTINEZ, Ricardo ,  HILL, Ronald, J. ,  FLANAGAN, Peter

IPC分类号： C07K14/47

CPC分类号： C12N9/16 ,  A61K38/00

摘要： The present invention relates to phosphatase polypeptides, nucleotide sequences encoding the phosphatase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various phosphatase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the MAP kinase phosphatase PTP's and STP's have been identified and their protein structure predicted.