公开(公告)号：EP3248011A2

公开(公告)日：2017-11-29

申请号：EP16740774.1

申请日：2016-01-21

申请人： T2 Biosystems, Inc. ,  Townsend, Jessica Ann ,  Snyder, Jessica Lee ,  Giese, Heidi Susanne ,  Bandoski-Cralinski, Cheryl Ann ,  Logan, Daniella Lynn

发明人： TOWNSEND, Jessica, Ann ,  SNYDER, Jessica, Lee ,  GIESE, Heidi, Susanne ,  BANDOSKI-GRALINSKI, Cheryl, Ann ,  LOGAN, Daniella, Lynn ,  THOMANN, Ulrich, Hans ,  NEELY, Lori, Anne ,  DHANDA, Rahul, Krishan ,  SWEENEY, Frederic ,  LOWERY, Thomas, Jay, Jr.

IPC分类号： G01N33/554 ,  C07H21/04

CPC分类号： C12Q1/689 ,  C12N15/1013 ,  C12Q2600/112 ,  C12Q2600/124 ,  C12Q2600/156 ,  G01N24/08 ,  G01N2333/20 ,  G01N2800/26 ,  Y02A50/57

摘要： The invention features methods, systems, and panels for rapid detection of tick-borne pathogens in a sample (including Borrelia spp. such as B. burgdorferi, B. afzelii, and B. garinii) and for diagnosis and monitoring of tick-transmitted diseases, including Lyme disease, Rocky Mountain spotted fever, Q-fever, babesiosis, ehrlichiosis, tularemia, and anaplasmosis.

公开(公告)号：EP2985633A2

公开(公告)日：2016-02-17

申请号：EP15002772.0

申请日：2011-10-19

申请人： T2 Biosystems, Inc.

发明人： LOWERY, Thomas, Jay, Jr. ,  AUDEH, Mark, John ,  BLANCO, Matthew ,  CHEPIN, James, Franklin ,  DEMAS, Vasiliki ,  DHANDA, Rahul ,  FRITZEMEIER, Marilyn, Lee ,  KOH, Isaac ,  KUMAR, Sonia ,  NEELY, Lori, Anne ,  MOZELESKI, Brian ,  PLOURDE, Daniella, Lynn ,  RITTERSHAUS, Charles, William ,  WELLMAN, Parris

IPC分类号： G01V3/00 ,  G01N33/543 ,  G01R33/12

CPC分类号： G01N27/745 ,  B82Y25/00 ,  C12Q1/6825 ,  C12Q1/6827 ,  C12Q1/689 ,  C12Q1/6895 ,  C12Q1/701 ,  C12Q2600/156 ,  G01N24/08 ,  G01N33/54326 ,  G01N33/5434 ,  G01R33/093 ,  G01R33/1269 ,  G01R33/281 ,  G01R33/30 ,  G01R33/302 ,  G01R33/448 ,  Y10T436/24 ,  C12Q2563/143 ,  C12Q2565/633

摘要： This invention features magnetic sensor based systems and methods for the detection of analytes, such as nucleic acids and pathogens. In particular systems employing an RF pulse in combination with a bias magnetic field methods are featured. Magnetic particles used have a mean particle diameter between 700 and 950 nm, leading to an increased sensitivity as a consequence of increased size aggregates with an increased T2 relaxivity. A removable cartridge for insertion and removal from the system is also described.

摘要翻译： 本发明的特征是基于磁性传感器的系统和方法，用于检测分析物，如核酸和病原体。 特别是采用RF脉冲结合偏置磁场方法的系统。 使用的磁性颗粒的平均粒径在700-950nm之间，由于T2弛豫率增加而尺寸增加的聚集体导致灵敏度增加。 还描述了用于插入和从系统移除的可移除盒。

公开(公告)号：EP2839038A1

公开(公告)日：2015-02-25

申请号：EP13779063.0

申请日：2013-03-14

申请人： T2 Biosystems, Inc.

发明人： NEELY, Lori, Anne

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6895 ,  C12Q1/6818 ,  C12Q2600/158 ,  C12Q2600/16

摘要： The invention features compositions and methods for the detection of Candida species in biological samples, such as human tissue samples. The invention features species specific nucleic acid probes that can hybridize to target nucleic acid molecules in Candida species and can be used in a variety of detection assays, such as fluorescence based assays or NMR based assays. The compositions and methods of the invention can be used to rapidly and accurately detect one or more Candida species in patients and can be used to assist in point-of care-decisions for treating Candida infections.

公开(公告)号：EP3524692A1

公开(公告)日：2019-08-14

申请号：EP19150640.1

申请日：2013-03-14

申请人： T2 Biosystems, Inc.

发明人： NEELY, Lori, Anne

IPC分类号： C12Q1/68 ,  C12Q1/6895 ,  C12Q1/6818

摘要： The invention features compositions and methods for the detection of Candida species in biological samples, such as human tissue samples. The invention features species specific nucleic acid probes that can hybridize to target nucleic acid molecules in Candida species and can be used in a variety of detection assays, such as fluorescence based assays or NMR based assays. The compositions and methods of the invention can be used to rapidly and accurately detect one or more Candida species in patients and can be used to assist in point-of care-decisions for treating Candida infections.

公开(公告)号：EP2839038B1

公开(公告)日：2019-01-16

申请号：EP13779063.0

申请日：2013-03-14

申请人： T2 Biosystems, Inc.

发明人： NEELY, Lori, Anne

IPC分类号： C12Q1/6895

公开(公告)号：EP3405479A1

公开(公告)日：2018-11-28

申请号：EP17742048.6

申请日：2017-01-20

申请人： T2 Biosystems, Inc.

发明人： THOMANN, Ulrich, Hans ,  NEELY, Lori, Anne ,  GIESE, Heidi, Susanne ,  TOWNSEND, Jessica, Ann ,  DHANDA, Rahul, Krishan ,  LOWERY, Thomas, Jay,Jr. ,  VED, Urvi ,  MANNING, Brendan ,  PHUNG, Nu, Ai ,  GARVER, Joanne, Lawton ,  STONE, Benjamin, B.

IPC分类号： C07K14/22 ,  C12Q1/04 ,  C12Q1/68 ,  G01N27/74

CPC分类号： C07K14/22 ,  C12Q1/04 ,  C12Q1/689 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/56911 ,  G01N33/6893

摘要： The invention features methods, panels, cartridges, and systems for detecting pathogens and for diagnosing and treating diseases, including bacteremia and sepsis.

公开(公告)号：EP2985633A3

公开(公告)日：2016-03-23

申请号：EP15002772.0

申请日：2011-10-19

申请人： T2 Biosystems, Inc.

发明人： LOWERY, Thomas, Jay, Jr. ,  AUDEH, Mark, John ,  BLANCO, Matthew ,  CHEPIN, James, Franklin ,  DEMAS, Vasiliki ,  DHANDA, Rahul ,  FRITZEMEIER, Marilyn, Lee ,  KOH, Isaac ,  KUMAR, Sonia ,  NEELY, Lori, Anne ,  MOZELESKI, Brian ,  PLOURDE, Daniella, Lynn ,  RITTERSHAUS, Charles, William ,  WELLMAN, Parris

IPC分类号： G01V3/00 ,  G01N33/543 ,  G01R33/12

CPC分类号： G01N27/745 ,  B82Y25/00 ,  C12Q1/6825 ,  C12Q1/6827 ,  C12Q1/689 ,  C12Q1/6895 ,  C12Q1/701 ,  C12Q2600/156 ,  G01N24/08 ,  G01N33/54326 ,  G01N33/5434 ,  G01R33/093 ,  G01R33/1269 ,  G01R33/281 ,  G01R33/30 ,  G01R33/302 ,  G01R33/448 ,  Y10T436/24 ,  C12Q2563/143 ,  C12Q2565/633

摘要： This invention features magnetic sensor based systems and methods for the detection of analytes, such as nucleic acids and pathogens. In particular systems employing an RF pulse in combination with a bias magnetic field methods are featured. Magnetic particles used have a mean particle diameter between 700 and 950 nm, leading to an increased sensitivity as a consequence of increased size aggregates with an increased T2 relaxivity. A removable cartridge for insertion and removal from the system is also described.

摘要翻译： 本发明的特征在于基于磁传感器的系统和用于检测分析物例如核酸和病原体的方法。 特别是采用与偏磁场方法结合的RF脉冲的系统。 使用的磁性颗粒具有700和950nm之间的平均粒径，导致随着T2弛豫度增加而增加尺寸聚集体的结果，增加灵敏度。 还描述了用于从系统插入和移除的可移除盒。

公开(公告)号：EP2630517B1

公开(公告)日：2016-03-16

申请号：EP11835088.3

申请日：2011-10-19

申请人： T2 Biosystems, Inc.

发明人： LOWERY, Thomas, Jay, Jr. ,  AUDEH, Mark, John ,  BLANCO, Matthew ,  CHEPIN, James, Franklin ,  DEMAS, Vasiliki ,  DHANDA, Rahul ,  FRITZEMEIER, Marilyn, Lee ,  KOH, Isaac ,  KUMAR, Sonia ,  NEELY, Lori, Anne ,  MOZELESKI, Brian ,  PLOURDE, Daniella, Lynn ,  RITTERSHAUS, Charles, William ,  WELLMAN, Parris

IPC分类号： B82Y25/00 ,  C12Q1/68 ,  C12Q1/70 ,  G01N24/08 ,  G01R33/09 ,  G01N33/543 ,  G01R33/12

CPC分类号： G01N33/54326 ,  B82Y25/00 ,  C12Q1/6825 ,  C12Q1/6827 ,  C12Q1/689 ,  C12Q1/6895 ,  C12Q1/70 ,  C12Q1/701 ,  G01N24/08 ,  G01N27/745 ,  G01N33/5434 ,  G01N33/9493 ,  G01R33/093 ,  G01R33/1269 ,  G01R33/281 ,  G01R33/302 ,  G01R33/448 ,  C12Q2563/143 ,  C12Q2565/633 ,  C12Q2563/149 ,  C12Q2565/113

公开(公告)号：EP3405559A1

公开(公告)日：2018-11-28

申请号：EP17742044.5

申请日：2017-01-20

申请人： T2 Biosystems, Inc.

发明人： LOWERY, Thomas, Jay, Jr. ,  PFALLER, Michael, Andy ,  DHANDA, Rahul, Krishan ,  MCDONOUGH, John, J. ,  MAGNUSON, Glenn ,  NEELY, Lori, Anne ,  THOMANN, Ulrich, Hans ,  HARRIS, William, Coulter ,  BLACK, Justin, Layne

IPC分类号： C12M1/00 ,  C12M1/26 ,  C12M1/28 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/68 ,  C12Q1/70

CPC分类号： C12Q1/70 ,  C12Q1/04 ,  C12Q1/68 ,  C12Q1/689 ,  C12Q1/6893 ,  C12Q2600/158 ,  Y02A50/57

摘要： The invention features methods, panels, cartridges, kits, and systems for rapid and sensitive detection and identification of pathogens and determination of the pathogen's susceptibility to antimicrobial agents for diagnosis and treatment of disease, including bloodstream infection (e.g., bacteremia and fungemia), and sepsis.

公开(公告)号：EP2817247B1

公开(公告)日：2018-04-11

申请号：EP13751876.7

申请日：2013-02-21

申请人： T2 Biosystems, Inc.

发明人： SUCHOCKI, Adam ,  AUDEH, Mark, John ,  BLANCO, Matthew ,  CHEPIN, James, Franklin ,  DEMAS, Vasiliki ,  FRITZEMEIER, Marilyn, Lee ,  LOWERY, Thomas, Jay ,  MIN, Michael ,  NEELY, Lori, Anne ,  RITTERSHAUS, Charles, William ,  WANG, Hwa-tang ,  WELLMAN, Parris, S.

IPC分类号： B65D90/02

CPC分类号： B01F9/0014 ,  B01F13/0052 ,  B01F15/00876 ,  B01F15/00896 ,  B01F2215/0431 ,  B65D1/46 ,  B65D2221/00 ,  C12M47/06 ,  C12N1/066 ,  C12Q1/6816 ,  C12Q1/686 ,  G01N27/745 ,  G01N33/492 ,  C12Q2523/32 ,  C12Q2527/146 ,  C12Q2563/143

摘要： The present invention relates to containers for holding liquid samples. The containers may be useful for mixing a liquid sample or lysing cells in a liquid sample. The invention also relates to methods of using the containers of the invention.