公开(公告)号：EP0748808A1

公开(公告)日：1996-12-18

申请号：EP95909107.5

申请日：1995-02-17

申请人： TAISHO PHARMACEUTICAL CO. LTD

发明人： OHUCHI, Yutaka Taisho Pharmaceutical Co., Ltd. ,  SUZUKI, Masaji Taisho Pharmaceutical Co., Ltd. ,  ASANUMA, Hajime Taisho Pharmaceutical Co., Ltd. ,  YOKOMORI, Sadakazu Taisho Pharmaceutical Co.,Ltd. ,  HATAYAMA, Katsuo Taisho Pharmaceutical Co., Ltd. ,  ISOBE, Yoshihiko Taisho Pharmaceutical Co., Ltd. ,  KIJIMA, Haruko Taisho Pharmaceutical Co., Ltd. ,  MURAMATSU, Makoto Taisho Pharmaceutical Co., Ltd.

IPC分类号： C07D471/18 ,  A61K31/47

CPC分类号： C07D451/12

摘要： Endo-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 1-isopropyl-2(1H)-quinolone-3-carboxylate represented by Formula (I):
or an acid addition salt thereof acts on a serotonin 4 receptor thereby to have a serotonin-like receptor stimulating activity, therefore has an action on activating gastrointestinal motor functions and thus is effective for the improvement of gastrointestinal conditions such as heartburn, anorexia, bowel pain or abdominal distension accompanied by chronic gastritis or postoperative gastroparesis, and further for the treatment of gastro-esophagal reflux, intestinal pseudo-obstruction or constipation.

摘要翻译： 由式（I）表示的内 - （8-甲基-8-氮杂双环[3.2.1]辛-3-基）-1-异丙基-2（1H） - 喹诺酮-3-羧酸酯：其或其酸加成盐作用于 5-羟色胺4受体因此具有5-羟色胺样受体刺激活性，因此具有激活胃肠运动功能的作用，因此有助于改善胃肠道状况，例如伴有慢性胃炎的胃灼热，食欲缺乏，肠痛或腹胀，或 术后胃轻瘫，并进一步治疗胃食管反流，肠假性梗阻或便秘。

公开(公告)号：EP0710662A1

公开(公告)日：1996-05-08

申请号：EP95918742.8

申请日：1995-05-18

申请人： TAISHO PHARMACEUTICAL CO. LTD

发明人： OHUCHI, Yutaka Taisho Pharmaceutical Co., Ltd. ,  SUZUKI, Masaji Taisho Pharmaceutical Co., Ltd. ,  ASANUMA, Hajime Taisho Pharmaceutical Co., Ltd. ,  YOKOMORI, Sadakazu Taisho Pharmaceutical Co.,Ltd. ,  HATAYAMA, Katsuo Taisho Pharmaceutical Co., Ltd.

IPC分类号： C07D451/04 ,  C07D451/06 ,  A61K31/435

CPC分类号： C07D451/04 ,  C07D451/12

摘要： A quinolinecarboxylic acid represented by general formula (C) or a medicinally acceptable salt thereof, each having a serotonergic receptor-stimulating effect on sertonin 4 receptors. In said formula, C represents hydroxymethyl, methoxy, ethoxy or morpholinyl. Therefore they have the effect of activating digestive motion and are efficacious in ameliorating chronic gastritis, diabetes and various diseases accompanying the lowering of stomach motility and gastric excretory function after gastrectomy, such as heartburn, anorexia, epigastralgia and abdominal swelling, and in treating reflux esophagitis, false ileus and constipation.

摘要翻译： 由通式（C）表示的喹啉羧酸或其药学上可接受的盐，其对sertonin 4受体具有5-羟色胺能受体刺激作用。 在所述式中，C代表羟甲基，甲氧基，乙氧基或吗啉基。 因此，它们具有激活消化运动的作用，并且有效改善慢性胃炎，糖尿病和伴随胃切除术后胃运动性和胃排泄功能降低的各种疾病，例如胃灼热，厌食，上腹痛和腹部肿胀，以及治疗反流性食管炎 ，肠梗阻和便秘。