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    Imidazopyridine derivatives and process for preparation thereof
    4.
    发明公开
    Imidazopyridine derivatives and process for preparation thereof 失效
    咪唑并吡啶衍生物和Verfahrenfürihre Herstellung。

    公开(公告)号：EP0531874A1

    公开(公告)日：1993-03-17

    申请号：EP92114976.1

    申请日：1992-09-02

    申请人： TANABE SEIYAKU CO., LTD.

    发明人： Honma, Yasushi ,  Sekine, Yasuo ,  Nomura, Sumihiro ,  Naito, Kazuaki ,  Narita, Hiroshi

    IPC分类号： C07D471/04 ,  A61K31/44

    CPC分类号： C07D471/04

    摘要： An imidazopyridine derivative of the formula [I]:

    wherein R¹ is hydrogen or lower alkyl, R² is hydrogen, lower alkylsulfonyl or a group of the formula:

    (Z is oxygen atom or two hydrogen, R⁰ is substituted or unsubstituted lower alkyl, lower alkoxy, 5- or 6-membered heteromonocyclic, substituted or unsubstituted phenyl, hydrogen, substituted or unsubstitued amino or lower alkenyl), R³ is carboxyl or lower alkoxycarbonyl and Ring A is substituted or unsubstituted phenyl, and pharmaceutically acceptable salt thereof, and processes for preparation thereof, said imidazopyridine derivatives have excellent angiotensin II antagonistic activities and are useful in prophylaxis and treatment of hypertension.

    摘要翻译： 式[I]的咪唑并吡啶衍生物：其中R 1为氢或低级烷基，R 2为氢，低级烷基磺酰基或下式基团：其中Z为氧原子或两个 氢，R 0是取代或未取代的低级烷基，低级烷氧基，5或6元杂单环，取代或未取代的苯基，氢，取代或未取代的氨基或低级烯基），R 3是羧基或低级烷氧基羰基， 环A是取代或未取代的苯基及其药学上可接受的盐及其制备方法，所述咪唑并吡啶衍生物具有优异的血管紧张素II拮抗活性，可用于预防和治疗高血压。

    S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds as intermediates for camptothecin derivatives
    6.
    发明公开
    S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds as intermediates for camptothecin derivatives 失效
    2-取代基羟基-2-二氢吲哚基酯基酯S-Reihe als Camptothecin-Zwischnprodukte

    公开(公告)号：EP0845464A2

    公开(公告)日：1998-06-03

    申请号：EP97308549.1

    申请日：1997-10-27

    申请人： TANABE SEIYAKU CO., LTD.

    发明人： Kawaguchi, Takayuki ,  Nomura, Sumihiro ,  Tsujihara, Kenji

    IPC分类号： C07D491/20 ,  C07D491/22

    CPC分类号： C07D491/14 ,  C07B2200/07 ,  C07D209/42 ,  C07D217/26

    摘要： A process for preparing S type 2-substituted hydroxy-2-indolidinyl-butyric ester compound [II]:
    wherein R° is residue of nitrogen-containing fused heterocyclic carboxylic acid having absolute configuration of "R"(in which the nitrogen atom is protected), R 1 and R 2 are lower alkyl group, and E is ester residue, which is useful as an intermediate for preparing camptothecin derivatives having antitumor activities,
       comprises 2-ethylating 2-substituted hydroxy-2-indolidinylacetic ester compound [I]:
    wherein the symbols are as defined above.

    摘要翻译： 制备S型2-取代羟基-2-吲哚哩啶基 - 丁酸酯化合物的方法ÄIIÜ：其中R DEG为绝对构型为“R”的含氮稠合杂环羧酸的残基（其中氮原子为 保护），R 1和R 2为低级烷基，E为酯残基，其可用作制备具有抗肿瘤活性的喜树碱衍生物的中间体，包括2-乙基化2-取代的羟基-2-吲哚哩啶基乙酸酯 化合物ÄIÜ：其中符号如上所定义。