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1.发明公开
公开(公告)号：EP0270093A2
公开(公告)日：1988-06-08
申请号：EP87117822.4
申请日：1987-12-02
IPC分类号： C07D211/76 , C07D211/72 , C07D207/26 , C07D207/24 , C07D401/04 , A61K31/435 , A61K31/40
CPC分类号： C07D207/267 , C07D207/24 , C07D207/26 , C07D207/27 , C07D211/72 , C07D211/76 , C07D401/04
摘要： There are disclosed a lactam derivative of the formula:
wherein R 1 is a substituted or unsubstituted phenyl group; R 2 is a substituted or unsubstituted phenyl group, a cycloalkyl group or a nitrogen-containing 6-membered heterocyclic group; Z is oxygen atom or sulfur atom; and n is an integer of 2 or 3, and a salt thereof, and a preparation thereof.
The above lactam derivative is novel and useful as a pharmaceutical compound. Accordingly, pharmaceutical preparations are also provided, together with the use of such derivatives for the manufacture of a medicament having valuable therapeutic properties.摘要翻译： 有游离缺失圆盘式的内酰胺衍生物：
worin - [R <1>是substituiertem奥德unsubstituiertem苯基; [R <2>是substituiertem奥德unsubstituiertem苯基，环烷基或含氮的6员杂环基团; Z是氧原子或硫原子; 和n是2或3的整数，和它们的盐，及其制备。 上述内酰胺衍生物是新颖的和有用的药物化合物。 因此，因此，提供的药物制剂，在使用衍生物的搜索具有有价值的治疗性质的药物中的用途在一起。 -
2.发明公开Lactam derivatives, processes for the preparation thereof, pharmaceutical compositions comprising the same, and the use of such derivatives for the manufacture of a medicament having valuable therapeutic properties 失效LACTAM衍生物，其制备方法，包含其的药物组合物，以及这些衍生物在制备具有可控治疗性质的药物中的用途
公开(公告)号：EP0270093A3
公开(公告)日：1989-12-27
申请号：EP87117822.4
申请日：1987-12-02
IPC分类号： C07D211/76 , C07D211/72 , C07D207/26 , C07D207/24 , C07D401/04 , A61K31/435 , A61K31/40
CPC分类号： C07D207/267 , C07D207/24 , C07D207/26 , C07D207/27 , C07D211/72 , C07D211/76 , C07D401/04
摘要： There are disclosed a lactam derivative of the formula:
wherein R 1 is a substituted or unsubstituted phenyl group; R 2 is a substituted or unsubstituted phenyl group, a cycloalkyl group or a nitrogen-containing 6-membered heterocyclic group; Z is oxygen atom or sulfur atom; and n is an integer of 2 or 3, and a salt thereof, and a preparation thereof. The above lactam derivative is novel and useful as a pharmaceutical compound. Accordingly, pharmaceutical preparations are also provided, together with the use of such derivatives for the manufacture of a medicament having valuable therapeutic properties.
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