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1.发明公开
公开(公告)号：EP0954328A1
公开(公告)日：1999-11-10
申请号：EP97928841.0
申请日：1997-06-04
发明人： BURGESON, Robert, E. , TSUNENAGA, Makoto , AMANO, Satoshi , NISHIYAMA, Toshio , ADACHI, Eijiro , SHIOYA, Nobuyuji
CPC分类号： C12N5/0629 , A61K38/39 , A61L27/227 , A61L27/3813 , A61L27/60 , C12N5/0068 , C12N2501/58 , C12N2533/52 , Y10S623/901
摘要： The use of laminin-5 to promote formation of basement membrane and to form skin equivalents and to improve grafting of keratinocyte sheets.
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公开(公告)号：EP1067968B1
公开(公告)日：2007-02-28
申请号：EP98918893.3
申请日：1998-04-30
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , A61K49/0006 , A61K49/0008
摘要： The invention provides methods of evaluating a treatment for its effect on skin. The invention also provides non-human transgenic animals, e.g., mice, having a reporter gene coupled to a skin-metabolism promoter.
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公开(公告)号：EP1067968A1
公开(公告)日：2001-01-17
申请号：EP98918893.3
申请日：1998-04-30
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , A61K49/0006 , A61K49/0008
摘要： The invention provides methods of evaluating a treatment for its effect on skin. The invention also provides non-human transgenic animals, e.g., mice, having a reporter gene coupled to a skin-metabolism promoter.
摘要翻译： 本发明提供了评估治疗对皮肤作用的方法。 本发明还提供了具有与皮肤代谢启动子偶联的报道基因的非人转基因动物，例如小鼠。
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公开(公告)号：EP1215959A1
公开(公告)日：2002-06-26
申请号：EP00960031.3
申请日：2000-09-08
IPC分类号： A01K67/00
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2227/108 , A01K2267/0393 , C07K14/43595 , C12N9/6448 , C12N9/6491 , C12N2830/008
摘要： The invention provides methods of evaluating a treatment for its effect on skin. The invention also provides non-human transgenic animals, e.g., mice, having a reporter gene coupled to a skin-metabolism promoter.
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