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公开(公告)号：EP1267616A1
公开(公告)日：2003-01-02
申请号：EP01926479.5
申请日：2001-03-30
IPC分类号： A01N37/18 , A61K38/00 , A61K48/00 , C12N5/02 , C12N15/63 , C12N15/64 , C12N15/85 , C12N15/87 , C12N15/90
CPC分类号： C12N5/0627 , A61K8/99 , A61K33/14 , A61K38/18 , A61K48/00 , A61Q7/00 , C12N2500/12 , C12N2501/415 , G01N33/6872 , G01N2333/475 , G01N2500/00
摘要： The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt protein or administering an agent which mimics an effect of Wnt promoted signal transduction, e.g., by administering lithium chloride. Methods of inhibiting hair growth are also provided.
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公开(公告)号：EP1181352A1
公开(公告)日：2002-02-27
申请号：EP99945293.1
申请日：1999-08-27
发明人： BURGESON, Robert , KISHIMOTO, Jiro
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , A61K38/39 , A61K48/00 , A61K49/0004 , C12N2517/02
摘要： The invention describes versican activation and modulation of hair growth, e.g., versican expressing dermal papilla cells exhibit hair induction ability.
摘要翻译： 本发明描述了多能聚糖的活化和对毛发生长的调节，例如表达多功能蛋白聚糖的真皮乳头细胞表现出毛发诱导能力。
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公开(公告)号：EP1267616B1
公开(公告)日：2007-08-08
申请号：EP01926479.5
申请日：2001-03-30
CPC分类号： C12N5/0627 , A61K8/99 , A61K33/14 , A61K38/18 , A61K48/00 , A61Q7/00 , C12N2500/12 , C12N2501/415 , G01N33/6872 , G01N2333/475 , G01N2500/00
摘要： The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt protein or administering an agent which mimics an effect of Wnt promoted signal transduction, e.g., by administering lithium chloride. Methods of inhibiting hair growth are also provided.
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公开(公告)号：EP1067968B1
公开(公告)日：2007-02-28
申请号：EP98918893.3
申请日：1998-04-30
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , A61K49/0006 , A61K49/0008
摘要： The invention provides methods of evaluating a treatment for its effect on skin. The invention also provides non-human transgenic animals, e.g., mice, having a reporter gene coupled to a skin-metabolism promoter.
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公开(公告)号：EP1215959A1
公开(公告)日：2002-06-26
申请号：EP00960031.3
申请日：2000-09-08
IPC分类号： A01K67/00
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2227/108 , A01K2267/0393 , C07K14/43595 , C12N9/6448 , C12N9/6491 , C12N2830/008
摘要： The invention provides methods of evaluating a treatment for its effect on skin. The invention also provides non-human transgenic animals, e.g., mice, having a reporter gene coupled to a skin-metabolism promoter.
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公开(公告)号：EP1067968A1
公开(公告)日：2001-01-17
申请号：EP98918893.3
申请日：1998-04-30
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , A61K49/0006 , A61K49/0008
摘要： The invention provides methods of evaluating a treatment for its effect on skin. The invention also provides non-human transgenic animals, e.g., mice, having a reporter gene coupled to a skin-metabolism promoter.
摘要翻译： 本发明提供了评估治疗对皮肤作用的方法。 本发明还提供了具有与皮肤代谢启动子偶联的报道基因的非人转基因动物，例如小鼠。
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