公开(公告)号：EP4423238A1

公开(公告)日：2024-09-04

申请号：EP22888080.3

申请日：2022-10-25

申请人： Satellite Biosciences, Inc.

发明人： WILSON, Christopher, Garrison ,  LEHMANN, Marcus ,  MORSE, Julie ,  ZHOU, Bridget ,  CHEN, Amanda ,  MOUA, Peter ,  MUNARIN, Fabiola ,  MARTURANO, Joseph, E.

IPC分类号： C12N5/02 ,  C12N5/10 ,  A61L27/54

CPC分类号： A61L27/54 ,  C12N2500/9020130101 ,  C12N2501/72720130101 ,  C12N2533/5220130101 ,  C12N2533/5620130101 ,  C12N2500/2520130101 ,  C12N2513/0020130101 ,  C12N5/0671 ,  C12M25/16 ,  C12N5/0656 ,  C12N5/067 ,  A61K35/33 ,  A61K35/39 ,  A61L27/225 ,  A61L27/52 ,  A61L27/3813 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/24 ,  A61L27/14 ,  A61L27/26 ,  A61L27/3687 ,  A61L27/3691 ,  A61L2300/6420130101 ,  A61L2300/60220130101 ,  A61L27/3886

公开(公告)号：EP3365037A1

公开(公告)日：2018-08-29

申请号：EP16858318.5

申请日：2016-10-21

申请人： Indiana University Research & Technology Corporation

发明人： KOEHLER, Karl, R. ,  LEE, Jiyoon

IPC分类号： A61L27/38 ,  A61L27/60 ,  A61K35/36 ,  C12N5/071 ,  C12N5/074

CPC分类号： C12N5/0698 ,  A61K35/36 ,  A61L27/362 ,  A61L27/3633 ,  A61L27/3641 ,  A61L27/3687 ,  A61L27/3813 ,  A61L27/3834 ,  A61L27/3839 ,  A61L27/3891 ,  A61L27/3895 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L27/60 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2300/64 ,  A61L2430/34 ,  A61L2430/40 ,  C12N5/0606 ,  C12N5/0629 ,  C12N2501/155 ,  C12N2501/999 ,  C12N2506/03 ,  C12N2506/1346 ,  C12N2513/00 ,  C12N2533/76 ,  C12Q1/6876 ,  C12Q2600/136

摘要： Provided herein are methods for directing differentiation of human pluripotent stem cells into a three-dimensional multilayered skin composition comprising an epidermal layer, a dermal layer, and a plurality of cells capable of forming a functional hair follicle. Also provided herein are three-dimensional, multilayered engineered skin compositions and methods of using the same for drug screening, for screening compounds for effects on hair growth, and for other applications.

公开(公告)号：EP3350312A1

公开(公告)日：2018-07-25

申请号：EP15779014.8

申请日：2015-09-15

申请人： Stellenbosch University

发明人： KLEINTJES, Wayne George

IPC分类号： C12N5/071 ,  A61K35/36 ,  A61L27/60 ,  A61P17/02 ,  C12M3/00

CPC分类号： C12M3/04 ,  A61F2002/048 ,  A61K35/36 ,  A61L27/3813 ,  A61L27/3895 ,  A61L27/60 ,  A61P17/02 ,  C12M23/20 ,  C12M23/34 ,  C12N5/0629 ,  C12N2502/115 ,  C12N2533/20

摘要： A method of culturing autogenous cells as well as a method of treating a mammalian patient is described. The cells are cultured on a substrate material having a surface treated with a fatty acid ester so as to have a strong hydrophobic surface and autogenous plasma obtained from a blood sample of the patient is used as a growth medium in order to culture the cells. The substrate material is also used as a transfer dressing for transferring the cultured cells to the patient and as a wound cover dressing. The invention also describes a kit as well as a system for culturing autogenous cells using the culture method.

公开(公告)号：EP2471902B1

公开(公告)日：2018-05-30

申请号：EP10811319.2

申请日：2010-08-25

申请人： Servicio Andaluz de Salud ,  Universidad de Granada

发明人： ALAMINOS MINGORANCE, Miguel ,  MUÑOZ ÁVILA, José Ignacio ,  GONZÁLEZ ANDRADES, Miguel ,  CAMPOS MUÑOZ, Antonio ,  GARZÓN BELLO, Ingrid Johanna

IPC分类号： A61L27/26 ,  A61L27/36 ,  A61L27/38 ,  A61L27/60 ,  A61K35/33 ,  A61K35/36 ,  A61K35/51 ,  C12N5/00 ,  C12N5/073 ,  C12N5/079 ,  C12N5/071

CPC分类号： A61L27/3804 ,  A61K35/33 ,  A61K35/36 ,  A61K35/51 ,  A61L27/26 ,  A61L27/3691 ,  A61L27/3813 ,  A61L27/60 ,  A61L2400/12 ,  A61L2430/16 ,  A61L2430/22 ,  C12N5/0068 ,  C12N5/0605 ,  C12N5/0621 ,  C12N5/0632 ,  C12N5/0684 ,  C12N5/0698 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2506/025 ,  C12N2533/56 ,  C12N2533/76 ,  C08L89/00 ,  C08L5/12

摘要： The present invention is encompassed in the field of biomedicine and more specifically tissue engineering. It relates specifically to an in vitro method for preparing an artificial tissue, to the artificial tissue obtainable by said method and to the use of this artificial tissue to partially or completely increase, restore or replace the functional activity of a damaged tissue or organ.

公开(公告)号：EP2582791B8

公开(公告)日：2018-05-23

申请号：EP11796538.4

申请日：2011-06-17

申请人： The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

发明人： THANGAPAZHAM, Rajesh ,  DARLING, Thomas, N. ,  LI, Shaowei

IPC分类号： A61L27/24 ,  A61L27/38 ,  A61L27/60 ,  C12N5/071 ,  A61F2/10 ,  A61K35/36

CPC分类号： A61L27/3886 ,  A61F2/105 ,  A61K35/36 ,  A61L27/24 ,  A61L27/3813 ,  A61L27/3834 ,  A61L27/60 ,  A61L2430/18 ,  C12N5/0627 ,  C12N5/0698 ,  C12N2501/04 ,  C12N2501/998 ,  C12N2502/092 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2502/30 ,  C12N2510/00 ,  C12N2533/78

摘要： This invention provides a skin substitute comprising epithelial cells and modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells, and methods for using the same. This invention also provides a method for transplanting cells capable of inducing hair follicles, comprising subdermally or intradermally delivering to a patient modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells.

公开(公告)号：EP3274005A1

公开(公告)日：2018-01-31

申请号：EP16713834.6

申请日：2016-03-25

申请人： Université de Bordeaux ,  Inserm ,  Centre Hospitalier Universitaire de Bordeaux

发明人： CASOLI, Vincent ,  CARIO-ANDRÉ, Muriel ,  LEPIVERT, Jean-Christophe

IPC分类号： A61L27/24 ,  A61L27/60 ,  A61L27/38 ,  A61F2/10 ,  C12N5/00

CPC分类号： C12N5/0698 ,  A61K35/35 ,  A61K35/36 ,  A61L27/24 ,  A61L27/3804 ,  A61L27/3813 ,  A61L27/3886 ,  A61L27/60 ,  A61P17/02 ,  A61P35/00 ,  C12N2500/32 ,  C12N2500/38 ,  C12N2501/905 ,  C12N2502/091 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2533/54

摘要： The present invention relates to a method for preparing a skin substitute, to a method for preparing a dermal substitute, to a skin substitute, to a dermal substitute and to a kit for implementing the method. The present invention also relates to a graft consisting of a skin substitute and to the use thereof as a means of treating a skin disorder and/or a loss of skin substance. The present invention can be used in particular in the pharmacological, medical and clinical fields.

公开(公告)号：EP3110450A4

公开(公告)日：2017-11-01

申请号：EP15755696

申请日：2015-02-26

申请人： UNIV OF MASSACHUSETTS MEDICAL SCHOOL

发明人： SONG JIE ,  XU JIANWEN

IPC分类号： A61K47/34 ,  A61L27/52

CPC分类号： A61L27/52 ,  A61K9/06 ,  A61K47/10 ,  A61L27/18 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3808 ,  A61L27/3813 ,  A61L27/3821 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/46 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  C08G65/33327 ,  C08G65/33396 ,  C08G2210/00 ,  C08G2230/00 ,  C08G2650/04 ,  C08G2650/30 ,  C08L71/02

摘要： The invention provides a novel approach to hydrogels with predictable degradation/gelling kinetics, which is useful for many biomedical applications where appropriate gelling kinetics and the timely disintegration of the hydrogel (e.g., drug delivery, guided tissue regeneration) is required. Precisely controlling hydrogel degradation over a broad range in a predictable manner is achieved via a simple but versatile hydrogel platform that allows formulation of hydrogels with predictable disintegration time from within 2 days to >250 days yet comparable macroscopic physical properties.

公开(公告)号：EP3110450A1

公开(公告)日：2017-01-04

申请号：EP15755696.0

申请日：2015-02-26

申请人： University of Massachusetts Medical School

发明人： SONG, Jie ,  XU, Jianwen

IPC分类号： A61K47/34 ,  A61L27/52

CPC分类号： A61L27/52 ,  A61K9/06 ,  A61K47/10 ,  A61L27/18 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3808 ,  A61L27/3813 ,  A61L27/3821 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/46 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  C08G65/33327 ,  C08G65/33396 ,  C08G2210/00 ,  C08G2230/00 ,  C08G2650/04 ,  C08G2650/30 ,  C08L71/02

摘要： The invention provides a novel approach to hydrogels with predictable degradation/gelling kinetics, which is useful for many biomedical applications where appropriate gelling kinetics and the timely disintegration of the hydrogel (e.g., drug delivery, guided tissue regeneration) is required. Precisely controlling hydrogel degradation over a broad range in a predictable manner is achieved via a simple but versatile hydrogel platform that allows formulation of hydrogels with predictable disintegration time from within 2 days to >250 days yet comparable macroscopic physical properties.

摘要翻译： 本发明提供了一种新颖的方法，以可预测的降解/胶凝动力学水凝胶，所有这对于许多生物医学应用位置适当胶凝动力学和水凝胶的及时崩解（例如，药物递送，引导组织再生）是必需的有用的。 精确地在宽范围的可预测的方式控制水凝胶降解是通过一个简单但通用平台水凝胶取得确实允许从在2天内>250天但可比宏观物理性能具有可预测的崩解时间的水凝胶制剂。

公开(公告)号：EP2352472B1

公开(公告)日：2017-01-04

申请号：EP09825325.5

申请日：2009-11-04

申请人： Stratatech Corporation

发明人： COMER, Allen, R. ,  ALLEN-HOFFMANN, B., Lynn ,  STEIGLITZ, Barry

IPC分类号： A61F2/10 ,  A61L27/54 ,  A61L27/60 ,  A61L27/38 ,  A61L27/36

CPC分类号： A61L27/3691 ,  A61F2/105 ,  A61L27/3813 ,  A61L27/54 ,  A61L27/60 ,  A61L2430/40

摘要： The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.

摘要翻译： 本发明一般涉及用于制备，储存，运送和使用由器官培养形成的皮肤等同物的系统和方法。 特别地，本发明涉及用于生产，运输，储存和使用由降温，优选2-8摄氏度至环境温度的器官培养产生的皮肤当量的系统和方法。 所述方法包括移植物的无菌包装，从而保持包装的无菌性和完整性，直到用于移植目的的使用时间为止。

公开(公告)号：EP2975117A4

公开(公告)日：2016-10-26

申请号：EP14762919

申请日：2014-03-09

申请人： JAPAN CHEM RES ,  KYOTO PREFECTURAL PUBLIC UNIV CORP

发明人： IMAGAWA KIWAMU ,  MAEDA KENICHI ,  HOSODA YUKI ,  YOKOYAMA SHUICHI ,  OKUMURA NAOKI ,  KOIZUMI NORIKO ,  KINOSHITA SHIGERU

IPC分类号： C12N5/071 ,  A61L27/00

CPC分类号： A61K35/36 ,  A61L27/3813 ,  A61L2430/16 ,  C12N5/0602 ,  C12N5/0621 ,  C12N2501/15 ,  C12N2501/727 ,  C12N2501/999 ,  C12N2502/1352

摘要： [Problem] To provide a method for producing human corneal epithelial sheet, wherein the human corneal epithelial-derived cells obtained by culturing human corneal epithelial cells are cultured on an amnion substrate. [Solution] A method for culturing human corneal epithelial cells using mesenchymal stem cells as the feeder cells; and a method for culturing human corneal epithelial cells using a medium containing a ROCK inhibitor, a phosphodiesterase inhibitor, a MAP kinase inhibitor and a TGF-6 receptor inhibitor in various combinations.

摘要翻译： 提供一种生产人角膜上皮片的方法，其中通过培养人角膜上皮细胞获得的人角膜上皮衍生细胞在羊膜基质上培养。 [解决方案]使用间充质干细胞作为饲养细胞培养人角膜上皮细胞的方法; 以及使用包含ROCK抑制剂，磷酸二酯酶抑制剂，MAP激酶抑制剂和TGF-6受体抑制剂的培养基以各种组合培养人角膜上皮细胞的方法。