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    METHOD OF TREATING PANCREATIC AND LIVER CONDITIONS BY TRANSPLANTATION OF STEM CELLS INTO BILE DUCT WALLS
    1.
    发明公开
    METHOD OF TREATING PANCREATIC AND LIVER CONDITIONS BY TRANSPLANTATION OF STEM CELLS INTO BILE DUCT WALLS 审中-公开
    通过将干细胞移植到胆管壁治疗胰腺和肝脏疾病的方法

    公开(公告)号：EP2970879A1

    公开(公告)日：2016-01-20

    申请号：EP14763985.0

    申请日：2014-03-13

    申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  University of Miami ,  Sapienza Universita di Roma

    发明人： REID, Lola, McAdams ,  WANG, Yunfang ,  GERBER, David, A. ,  LANZONI, Giacomo ,  INVERARDI, Luca ,  DOMINGUEZ-BENDALA, Juan ,  ALVARO, Domenico ,  CARDINALE, Vincenzo ,  GAUDIO, Eugenio ,  CARPINO, Guido

    IPC分类号： C12N5/00 ,  C12N5/02

    摘要： A method of repairing diseased or dysfunctional pancreas or liver is provided. The method involves preparation of a suspension of stem cells and/or progenitor cells such as biliary tree stem cells, hepatic stem cells, pancreatic stem cells or their descendants, committed progenitor cells, from healthy tissue of the patient or of the biliary tree of a non-autologous donor and engrafting the cells into the wall of bile ducts near to the organ to be treated. The graft consists of stem cells or progenitors that are admixed with biomaterials and, optionally, with cytokines and/or native epithelial-mesenchymal cells appropriate for the maturational lineage stage of the cells to be engrafted. The cells are specifically introduced to the hepato-pancreatic common duct of the subject for treatment of pancreatic conditions or to the bile duct wall near to the liver for treatment of liver conditions and allowed to migrate to the pancreas or to the liver and expand and then rebuild part or the entirety of the diseased or dysfunctional organ.

    摘要翻译： 提供了修复患病或功能失调的胰腺或肝脏的方法。 该方法涉及制备来自患者的健康组织或胆管树的干细胞和/或祖细胞（例如胆管树干细胞，肝干细胞，胰干细胞或其后代，定向祖细胞）的悬液 非自体供体并将细胞移植到待治疗器官附近的胆管壁中。 移植物由干细胞或祖细胞组成，所述干细胞或祖细胞与生物材料以及任选地与细胞因子和/或天然上皮 - 间充质细胞混合，所述细胞和/或天然上皮 - 间充质细胞适于待移植细胞的成熟谱系阶段。 将细胞特异性地引入受试者的肝胰腺共同导管中以治疗胰腺疾病或导管至肝脏附近的胆管壁以治疗肝病，并使其迁移至胰腺或肝脏并扩张，然后 重建部分或整个病变或机能不全的器官。

    MULTIPOTENT STEM CELLS FROM THE EXTRAHEPATIC BILIARY TREE AND METHODS OF ISOLATING SAME
    6.
    发明公开
    MULTIPOTENT STEM CELLS FROM THE EXTRAHEPATIC BILIARY TREE AND METHODS OF ISOLATING SAME 审中-公开

    公开(公告)号：EP3725874A1

    公开(公告)日：2020-10-21

    申请号：EP20178369.3

    申请日：2010-10-28

    申请人： University of North Carolina at Chapel Hill ,  Sapienza Universita di Roma

    发明人： REID, Lola M. ,  WANG, Yunfang ,  CARDINALE, Vincenzo ,  GAUDIO, Eugenio ,  CARPINO, Guido ,  ALVARO, Domenico ,  CUI, Cai-Bin

    IPC分类号： C12N5/071

    摘要： The present invention relates to a multipotent stem cell, multipotent cell populations, and an enriched multipotent cell population, each found in fetal, neonatal, pediatric, and adult biliary tree tissue and up to 72 hours post mortem (although preferentially, within 10 hours post mortem) and capable of maturing into multiple endodermal tissues that include liver, biliary and pancreatic tissues. The multipotent stem/progenitor cell and cell populations are found in peribiliary glands, and progenitors descending from them are present throughout the biliary tree including in the gallbladder. High numbers of the peribiliary glands are found in the branching locations of the biliary tree such as hilum, common hepatic duct, cystic duct, common duct, common hepato-pancreatic duct and gallbladder. Related multipotent cells, multipotent cell populations and their descendent progenitors are found throughout the biliary tree including in the gall bladder, which does not have peribiliary glands. Compositions comprising same, methods of identifying and isolating same, maintaining same in culture, expanding same in culture and differentiating or lineage restricting the same in vitro or in vivo to hepatic, biliary or pancreatic fates ( e.g ., as hepatocytes, cholangiocytes, and/or pancreatic islet cells) are also provided. Methods of using the multipotent cells and/or multipotent cell populations are also provided.