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公开(公告)号：EP0024739A2
公开(公告)日：1981-03-11
申请号：EP80105201.0
申请日：1980-09-02
发明人： Masahiko, Fujino , Chieko, Kitada
IPC分类号： C07C103/52
CPC分类号： C07K7/06 , C07K5/06026 , C07K5/06078 , C07K5/06104 , C07K5/06113 , C07K5/0613 , C07K5/0806 , C07K5/0819 , C07K5/0821 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K5/1021
摘要： Novel polyprenylpeptides oftheformula
wherein
X is peptide chain of H-Tyr-Pro-Glu-Ile-Ser-Trp-Thr-Arg-Asn-Gly- or H-Glu-His-Asp-Pro-Ser-Ala-Pro-Gly-Asn-Gly-Tyr-; Y is carboxyl which may be amidated or esterified with C 1-3 alkyl; and n is integer of3, 4or5.
have the stimulating effect on the mating tube formation of yeast.摘要翻译： 其中X是H-Tyr-Pro-Glu-Ile-Ser-Trp-Thr-Arg-Asn-Gly-或H-Glu-His-Asp-Pro-Ser-Ala-Pro-Gly- ASN-甘氨酸 - Tyr-; Y是可以被C1-3烷基酰胺化或酯化的羧基; n是3,4或5的整数。 对酵母的配合管形成具有刺激作用。
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公开(公告)号：EP0034721A2
公开(公告)日：1981-09-02
申请号：EP81100633.7
申请日：1981-01-29
IPC分类号： C07C103/52 , A61K37/02
CPC分类号： C07K14/675 , A61K38/00 , Y02P20/55 , Y10S514/809
摘要： Novel polypeptide of the formula: is useful as an analgesic agent.
摘要翻译： 下式的新型多肽：H-Tyr-Gly-Gly-Phe-Met-Lys-Pro-Tyr-Thr-Lys-Gln-Ser-His-Lys-Pro-Leu-IIe-Thr-Leu-Leu-Lys- His-Ile-Thr-Leu-Lys-Asn-Glu-Gln-OH可用作止痛剂。
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公开(公告)号：EP0005248A3
公开(公告)日：1979-11-28
申请号：EP79101282
申请日：1979-04-30
IPC分类号： C07C103/52
CPC分类号： C07K5/06026 , C07K5/0606 , C07K5/0812 , C07K5/1016
摘要： Novel tetrapeptidehydrazide derivatives, inclusive of a pharmacologically acceptable acid addition salt thereof, which has the general formula (I):
(wherein R, is hydrogen or lower alkyl; R 2 is hydrogen or the side chain of a D-a-amino acid; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, or a saturated or unsaturated and straight or branched lower aliphatic acyl group which may optionally be substituted by hydroxy amino lower alkoxy, halogen, oxo, lower alkylthio or lower alkylthiooxide), are useful as analgesics.摘要翻译： 具有通式（I）：其中R 1为氢或低级烷基; R 2为氢或D-α-氨基酸侧链的新型四肽酰肼衍生物，包括其药学上可接受的酸加成盐 R 3为氢或低级烷基; R 4为氢或可以被羟基氨基低级烷氧基，卤素，氧代，低级烷硫基或低级烷硫基氧基取代的饱和或不饱和的直链或支链低级脂族酰基）可用作 镇痛药。
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公开(公告)号：EP0056274B1
公开(公告)日：1984-05-09
申请号：EP82100156.7
申请日：1982-01-12
IPC分类号： C07D209/20 , C07C103/52
CPC分类号： C07D209/20 , C07K1/068 , C07K7/23 , Y02P20/55
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5.发明公开Tetrapeptidesemicarbazide derivatives and their production and use 失效Tetrapeptidsemicarbazid衍生物及其制备方法和用途。
公开(公告)号：EP0031567A2
公开(公告)日：1981-07-08
申请号：EP80108083.9
申请日：1980-12-20
IPC分类号： C07C103/52 , A61K37/02 , C07C133/00 , C07C159/00
CPC分类号： C07K5/0812 , C07K5/1016 , Y02P20/55
摘要： Novel tetrapeptidesemicarbazide derivatives, inclusive of a pharmacologically acceptable salt thereof, which has the general formula (I):
wherein R 1 is hydrogen or lower alkyl; R 2 is hydrogen or a D-α-amino acid side chain; R 3 is hydrogen or lower alkyl; X is oxygen or sulfur, are useful as analgesics.-
公开(公告)号：EP0056274A1
公开(公告)日：1982-07-21
申请号：EP82100156.7
申请日：1982-01-12
IPC分类号： C07D209/20 , C07C103/52
CPC分类号： C07D209/20 , C07K1/068 , C07K7/23 , Y02P20/55
摘要： An indole group in an amino acid or a peptide can be protected with a group shown by the formula:
wherein R 1 and R 5 each is hydrogen, methyl or methoxy; R 2 and R 4 each is hydrogen or methyl; R 3 is methyl or methoxy, respectively, and said group may easily be removed without affecting the amino acid or the peptide to be derived from the protected amino acid or peptide. Thus, the present invention is useful in the synthesis of peptide containing indole group.-
公开(公告)号：EP0024739A3
公开(公告)日：1981-09-16
申请号：EP80105201
申请日：1980-09-02
发明人： Masahiko, Fujino , Chieko, Kitada
IPC分类号： C07C103/52
CPC分类号： C07K7/06 , C07K5/06026 , C07K5/06078 , C07K5/06104 , C07K5/06113 , C07K5/0613 , C07K5/0806 , C07K5/0819 , C07K5/0821 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K5/1021
摘要： Novel polyprenylpeptides oftheformula
wherein
X is peptide chain of H-Tyr-Pro-Glu-Ile-Ser-Trp-Thr-Arg-Asn-Gly- or H-Glu-His-Asp-Pro-Ser-Ala-Pro-Gly-Asn-Gly-Tyr-; Y is carboxyl which may be amidated or esterified with C 1-3 alkyl; and n is integer of3, 4or5.
have the stimulating effect on the mating tube formation of yeast.摘要翻译： 新颖的具有下式的多肽，其中X是H-Tyr-Pro-Glu-Ile-Ser-Trp-Thr-Arg-Asn-Gly-或H-Glu-His-Asp-Pro-Ser-Ala的肽链 -Pro - 甘氨酸 - 天冬酰胺 - 甘氨酸 - Tyr-; Y是可以被C 1-3烷基酰胺化或酯化的羧基; 并且n为3,4或5的整数，对酵母的配合管形成具有刺激作用。
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公开(公告)号：EP0005248A2
公开(公告)日：1979-11-14
申请号：EP79101282.6
申请日：1979-04-30
IPC分类号： C07C103/52
CPC分类号： C07K5/06026 , C07K5/0606 , C07K5/0812 , C07K5/1016
摘要： Novel tetrapeptidehydrazide derivatives, inclusive of a pharmacologically acceptable acid addition salt thereof, which has the general formula (I):
(wherein R, is hydrogen or lower alkyl; R 2 is hydrogen or the side chain of a D-a-amino acid; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, or a saturated or unsaturated and straight or branched lower aliphatic acyl group which may optionally be substituted by hydroxy amino lower alkoxy, halogen, oxo, lower alkylthio or lower alkylthiooxide), are useful as analgesics.摘要翻译： 具有通式（I）的新型四肽酰肼衍生物，包括其药理学上可接受的酸加成盐：（其中R 1为氢或低级烷基; R 2为氢或Da-氨基酸的侧链; R 3为氢 或低级烷基; R 4是氢或可以任选被羟基氨基低级烷氧基，卤素，氧代，低级烷硫基或低级烷基硫氧化物取代的饱和或不饱和的直链或支链低级脂族酰基）可用作止痛剂。
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公开(公告)号：EP0005248B1
公开(公告)日：1982-03-24
申请号：EP79101282.6
申请日：1979-04-30
IPC分类号： C07C103/52
CPC分类号： C07K5/06026 , C07K5/0606 , C07K5/0812 , C07K5/1016
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公开(公告)号：EP0034721A3
公开(公告)日：1981-12-30
申请号：EP81100633
申请日：1981-01-29
IPC分类号： C07C103/52 , A61K37/02
CPC分类号： C07K14/675 , A61K38/00 , Y02P20/55 , Y10S514/809
摘要： Novel polypeptide of the formula: is useful as an analgesic agent.
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