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11 条记录 (耗时 0.014 秒)

    Phospholipids, their production and use thereof
    3.
    发明公开
    Phospholipids, their production and use thereof 失效
    Phospholipide，ihre Herstellung und ihre Verwendung。

    公开(公告)号：EP0108565A2

    公开(公告)日：1984-05-16

    申请号：EP83306549.3

    申请日：1983-10-27

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Nojima, Shoshichi ,  Nomura, Hiroaki

    IPC分类号： C07F9/09 ,  C07F9/58 ,  C07F9/113 ,  C07F9/40 ,  A61K31/685 ,  A01N57/10 ,  A01N57/18

    CPC分类号： C07F9/581 ,  C07F9/091 ,  C07F9/113 ,  C07F9/3808 ,  C07F9/4075

    摘要： Phospholipids, inclusive of pharmaceutically acceptable salts thereof, of the formula
    wherein R' is a C 8.30 aliphatic hydrocarbon residue, R 2 , R 3 and R 4 are independently hydrogen or lower alky or
    represents cyclic ammonio and n is 0 or 1, exhibit inhibitory activity to multiplication of tumor cells and antimycotic (antifungal) and antiprotozoal activities, and are useful for inhibiting multiplication of tumor cells and prolonging the survival time of tumor-bearing warm-blooded animals, for treating or preventing a disease in an animal caused by a mycete (fungus) and for treating or preventing a plant disease.

    摘要翻译： 其中R 1是C 3-30脂族烃残基，R 2，R 3和R 4独立地是氢或低级烷基，或者表示环状氨基，n是0或1的磷脂，包括其药学上可接受的盐， 对抗肿瘤细胞增殖和抗真菌活性和抗原生殖活性具有抑制活性，可用于抑制肿瘤细胞增殖，延长肿瘤生存时间，使其具有治疗或预防动物疾病 由真菌（真菌）引起并用于治疗或预防植物病害。

    Use of a phospholipid derivative
    7.
    发明公开
    Use of a phospholipid derivative 失效
    Verwendung eines Phospholipidderivats。

    公开(公告)号：EP0171968A1

    公开(公告)日：1986-02-19

    申请号：EP85305407.0

    申请日：1985-07-30

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Nojima, Shoshichi ,  Nomura, Hiroaki ,  Tsushima, Susumu

    IPC分类号： A61K31/685

    CPC分类号： A61K31/685 ,  C07D295/205 ,  C07F9/5721

    摘要： This invention provides a method for inhibiting the proliferation of tumors in a warm-blooded animal or prolonging the life span of said animal, which comprises administering to said animal an effective amount of a compound of the formula
    wherein R' is a C 14-19 alkyl group; R 2 , R 3 and R 4 are independently C 1-2 alkyl or
    represents a nitrogen-containing five- or six-membered heterocvclic rina: and
    is a nitrogen-containing four- to six-membered heterocyclic group, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for inibiting the proliferation of tumors in a warm-blooded animai or prolonging the life span of said animal.

    摘要翻译： 本发明提供一种抑制温血动物肿瘤增殖或延长所述动物寿命的方法，其包括向所述动物施用有效量的式CHEM的化合物，其中R 1为 C14-19烷基; R 2，R 3和R 4独立地为C 1-2烷基或表示含氮的五元或六元杂环; 和是含氮的四至六元杂环基或其药学上可接受的盐，用于制造用于抑制温血动物中的肿瘤增殖或延长所述 动物。