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48 条记录 (耗时 0.017 秒)

    Nitrogen- and sulfur-containing lipid compound, their production and use
    4.
    发明公开
    Nitrogen- and sulfur-containing lipid compound, their production and use 失效
    Stickstoff und Schwefel enthaltende Lipid-Verbindung，Herstellungsverfahren und Verwendung。

    公开(公告)号：EP0255366A2

    公开(公告)日：1988-02-03

    申请号：EP87306715.1

    申请日：1987-07-29

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Inoue, Keizo ,  Nomura, Hiroaki ,  Aono, Tetsuya

    IPC分类号： C07C317/02 ,  C07C321/02 ,  C07C323/23 ,  C07D213/20 ,  C07D277/22 ,  A61K31/14 ,  A61K31/44

    CPC分类号： C07D213/20 ,  C07D277/22

    摘要： A compound of the general formula [I]:
    wherein R₁ represents a higher alkyl group or an N-(higher alkyl)carbamoyl group, R₂ represents hydrogen, a lower alkyl group, an acyl group having at least three carbon atoms, an N-(lower alkyl)carbamoyl group, an N-(lower alkyl)thiocar­bamoyl group or a benzyl group, R represents a primary, secondary or tertiary amino group or a quaternary ammonium group, x is l or 2, y is 0, 1 or 2. and z is an integer of 2-l0, or a pharmaceutically acceptable salt thereof. The novel substances have both anti-tumor activity and platelet activating factor-inhibiting property, and they are effective as an anti-tumor agent without circulatory trouble.

    摘要翻译： 通式[I]的化合物：其中R 1表示高级烷基或N-（高级烷基）氨基甲酰基，R 2表示氢，低级烷基，具有至少3个碳原子的酰基， N-（低级烷基）氨基甲酰基，N-（低级烷基）硫代氨基甲酰基或苄基，R表示伯，仲或叔氨基或季铵基，x为1或2，y为0， 1或2，z为2〜10的整数，或其药学上可接受的盐。 新型物质具有抗肿瘤活性和血小板激活因子抑制特性，作为无循环障碍的抗肿瘤药物有效。

    Phospholipids, their production and use thereof
    6.
    发明公开
    Phospholipids, their production and use thereof 失效
    Phospholipide，ihre Herstellung und ihre Verwendung。

    公开(公告)号：EP0108565A2

    公开(公告)日：1984-05-16

    申请号：EP83306549.3

    申请日：1983-10-27

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Nojima, Shoshichi ,  Nomura, Hiroaki

    IPC分类号： C07F9/09 ,  C07F9/58 ,  C07F9/113 ,  C07F9/40 ,  A61K31/685 ,  A01N57/10 ,  A01N57/18

    CPC分类号： C07F9/581 ,  C07F9/091 ,  C07F9/113 ,  C07F9/3808 ,  C07F9/4075

    摘要： Phospholipids, inclusive of pharmaceutically acceptable salts thereof, of the formula
    wherein R' is a C 8.30 aliphatic hydrocarbon residue, R 2 , R 3 and R 4 are independently hydrogen or lower alky or
    represents cyclic ammonio and n is 0 or 1, exhibit inhibitory activity to multiplication of tumor cells and antimycotic (antifungal) and antiprotozoal activities, and are useful for inhibiting multiplication of tumor cells and prolonging the survival time of tumor-bearing warm-blooded animals, for treating or preventing a disease in an animal caused by a mycete (fungus) and for treating or preventing a plant disease.

    摘要翻译： 其中R 1是C 3-30脂族烃残基，R 2，R 3和R 4独立地是氢或低级烷基，或者表示环状氨基，n是0或1的磷脂，包括其药学上可接受的盐， 对抗肿瘤细胞增殖和抗真菌活性和抗原生殖活性具有抑制活性，可用于抑制肿瘤细胞增殖，延长肿瘤生存时间，使其具有治疗或预防动物疾病 由真菌（真菌）引起并用于治疗或预防植物病害。

    Deazapurine derivatives
    7.
    发明公开
    Deazapurine derivatives 失效
    Deazapurine衍生物

    公开(公告)号：EP0079447A1

    公开(公告)日：1983-05-25

    申请号：EP82108838.2

    申请日：1982-09-24

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Nishimura, Susumu ,  Nomura, Hiroaki

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： Novel deazapurine derivatives of the formula:
    wherein

    R 1 is C 1-18 alkyl which may be substituted with di-C 1-3 alkyl amino; C 1-18 alkenyl; C 3-8 cyloalkyl; C 5-8 cycloalkenyl; C 7-13 aralkyl which may be substituted with C 1-4 alkoxy, C 1-4 alkanoyl, C 2-4 alkoxycarbonyl, hydroxy, amino, nitro, trifluoromethyl or C 1-4 alkanoylamido; or C 6-10 aryl and
    R 2 is hydrogen or C 7-13 aralkyl or,
    R 1 and R 2 , taken together with the adjacent nitrogen atom, form a piperidine ring, and salt thereof are selectively taken up by tumor cells and have antitumor activity.

    摘要翻译： 下式的新型脱氮嘌呤衍生物：其中R1为可以被二-C1-3烷基氨基取代的C1-18烷基; C1-18链烯基; C3-8环烷基; C5-8环烯基; 可以被C1-4烷氧基，C1-4烷酰基，C2-4烷氧基羰基，羟基，氨基，硝基，三氟甲基或C1-4烷酰基酰氨基取代的C7-13芳烷基; 或C 6-10芳基，R 2为氢或C 7-13芳烷基，或者R 1和R 2与相邻的氮原子一起形成哌啶环，并且其盐被肿瘤细胞选择性吸收并具有抗肿瘤活性。

    Phospholipid derivatives, their production and use
    10.
    发明公开
    Phospholipid derivatives, their production and use 失效
    磷脂衍生物，其制备及其应用。

    公开(公告)号：EP0225129A1

    公开(公告)日：1987-06-10

    申请号：EP86309078.3

    申请日：1986-11-20

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Inoue, Keizo ,  Nomura, Hiroaki ,  Okutani, Tetsuya

    IPC分类号： C07F9/10 ,  C07F9/65 ,  A61K31/66

    CPC分类号： C07F9/581 ,  C07F9/10 ,  Y02P20/55

    摘要： Phospholipid derivatives of the formula:
    wherein R¹ is a higher alkyl, acylmethyl or alkylcarbamoyl group which may be substituted by cycloalkyl; R² is a lower alkyl which may be substituted by carboxy, formyl or lower acyl, a carbamcyl or thiocarbamoyl group which is substituted by lower alkyl, or an acetoacetyl group; R³, R⁴ and R⁵ are independently hydrogen or lower alkyl, or
    represents a cyclic ammonio group; and n represents an integer of 8 to 14, and salts thereof have antitumor activity and platelet activating factor inhibitory activity and are useful as antitumor agents.