公开(公告)号：EP4327882A3

公开(公告)日：2024-05-15

申请号：EP24150802.7

申请日：2018-09-07

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： LI, Lingyin ,  SMITH, Mark ,  SHAW, Kelsey Erin ,  CAROZZA, Jacqueline Ann ,  BOEHNERT, Volker

IPC分类号： A61K31/519 ,  C07D471/00 ,  A61P35/00

CPC分类号： C07F9/4003 ,  A61K31/519 ,  C07D401/04 ,  C07F5/025 ,  C07F9/00 ,  C07F9/091 ,  C07F9/1651 ,  C07F9/3826 ,  C07F9/4407

摘要： Compounds, compositions and methods are provided for the inhibition of ENPP 1. Aspects of the subject methods include contacting a sample with a ENPP1 inhibitor to inhibit cGAMP hydrolysis activity of ENPP1. In some cases, the ENPP1 inhibitor is cell impermeable. Also provided are compositions and methods for treating cancer. Aspects of the methods include administering to a subject a therapeutically effective amount of a ENPP 1 inhibitor to treat the subject for cancer. In certain cases, the cancer is a solid tumor cancer. Also provided are methods of administering radiation therapy to a subject either before or after administering an ENPP1 inhibitor. The radiation therapy can be administered at a dosage and/or frequency effective to reduce radiation damage to the subject. In certain cases, the method is performed in combination with a chemotherapeutic agent, or a checkpoint inhibitor, or both.

公开(公告)号：EP3401298A1

公开(公告)日：2018-11-14

申请号：EP16883870.4

申请日：2016-12-27

申请人： Tosoh Finechem Corporation

发明人： NAKAMURA, Shinichiro ,  KONDO, Norihisa ,  YAMASAKI, Takayuki ,  SHIRAI, Tomohiro

IPC分类号： C07C21/18 ,  C03C17/28 ,  C07F7/12 ,  C07F7/18 ,  C07F9/38 ,  C09K3/18

CPC分类号： C08F220/14 ,  B29C33/60 ,  C03C17/28 ,  C03C17/328 ,  C03C2218/111 ,  C03C2218/116 ,  C07C21/18 ,  C07C21/19 ,  C07C21/215 ,  C07C33/423 ,  C07C69/54 ,  C07F7/12 ,  C07F7/18 ,  C07F7/1804 ,  C07F9/091 ,  C07F9/38 ,  C09D133/16 ,  C09K3/18

摘要： To provide a novel fluorine-containing compound that does not include any long chain perfluoroalkyl unit having 8 or more carbon atoms, which is problematic in terms of the environment, and that is excellent in water repellency/oil repellency, and a surface modifier using the compound. [Solution] There are used a fluorine-containing compound represented by the following general formula (1), the following general formula (2) or the following general formula (5): Rf 1 -(CR 1 =CR 2 -X-Rf 2 ) n -Y-Z (1), Rf 1 -(X-CR 1 =CR 2 -Rf 2 ) n -Y-Z (2) or Rf 3 -(CF=CR 3 -CR 4 =CF-Rf 4 ) n -Y-Z (5); and a surface modifier using the compound.

公开(公告)号：EP3030568B1

公开(公告)日：2018-09-19

申请号：EP14749783.8

申请日：2014-08-05

申请人： Galapagos NV

发明人： VAN DER PLAS, Steven Emiel ,  MARTINA, Sébastien Laurent Xavier ,  DROPSIT-MONTOVERT, Sébastien Jean-Jacques Cédric ,  ANDREWS, Martin James Inglis ,  KELGTERMANS, Hans

IPC分类号： C07D495/04 ,  A61K31/38

CPC分类号： A61K31/381 ,  A61K31/38 ,  A61K31/4025 ,  A61K31/4155 ,  A61K31/4162 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/427 ,  A61K31/436 ,  A61K31/437 ,  A61K31/4436 ,  A61K31/497 ,  A61K31/501 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K31/675 ,  C07D495/04 ,  C07F7/0812 ,  C07F9/091 ,  C07F9/6561

摘要： wherein R1 is as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment cystic fibrosis by administering a compound of the invention.

公开(公告)号：EP3303420A2

公开(公告)日：2018-04-11

申请号：EP16818431.5

申请日：2016-06-02

申请人： University of Washington

发明人： JIANG, Shaoyi ,  BAI, Tao ,  ELLA-MENYE, Jean-Rene ,  HUNG, Hsiang-Chieh ,  JAIN, Priyesh ,  SINCLAIR, Andrew ,  SUNDARAM, Harihara Subramanian ,  LI, Yang ,  ZHANG, Peng

IPC分类号： C08F36/02 ,  C08F136/02

CPC分类号： C07F9/091 ,  A61K31/00 ,  C07C229/12 ,  C07C229/16 ,  C07C237/22 ,  C07C253/30 ,  C07C255/23 ,  C07C255/26 ,  C07C265/04 ,  C08F220/34 ,  C08F220/36 ,  C08F220/42 ,  C08F220/44 ,  C08F220/48 ,  C08F220/50 ,  C08F220/60 ,  C08F2220/603 ,  C08F2222/328 ,  C08G61/06 ,  C08G63/00 ,  C08F2220/606

摘要： Free-standing non-fouling polymers and polymeric compositions, monomers and macromonomers for making the polymers and polymeric compositions, objects made from the polymers and polymeric compositions, and methods for making and using the polymers and polymeric compositions.

公开(公告)号：EP2874207B1

公开(公告)日：2017-12-20

申请号：EP13816924.8

申请日：2013-07-10

申请人： LG Chem, Ltd.

发明人： AHN, Kyoung-Ho ,  LEE, Chul-Haeng ,  YANG, Doo-Kyung ,  KIM, Min-Jung ,  LEE, Jung-Hoon ,  JUNG, Yi-Jin

IPC分类号： H01M4/131 ,  H01M4/1391 ,  H01M4/485 ,  H01M4/62 ,  H01M4/36 ,  H01M10/052 ,  H01M4/04 ,  C07F9/09 ,  C08F222/10 ,  C08F230/02 ,  C09D133/14 ,  C09D143/02

CPC分类号： H01M4/62 ,  C07F9/091 ,  C08F222/1006 ,  C08F230/02 ,  C09D133/14 ,  C09D143/02 ,  H01M4/0404 ,  H01M4/131 ,  H01M4/1391 ,  H01M4/366 ,  H01M4/485 ,  H01M10/052 ,  H01M2220/10 ,  H01M2220/20 ,  Y02E60/122 ,  Y02P70/54 ,  Y02T10/7011

摘要： Disclosed are an anode for secondary batteries and a secondary battery including the same. The anode includes an anode mixture including an anode active material, coated on a current collector, wherein the anode active material includes lithium titanium oxide (LTO) particles provided on surfaces thereof with a cross-linked polymer coating layer, wherein the LTO particles with the cross-linked polymer coating layer formed thereon retain a porous structure formed therebetween, and a cross-linked polymer of the coating layer is a phosphate-based compound.

公开(公告)号：EP3105238A4

公开(公告)日：2017-11-08

申请号：EP15748902

申请日：2015-02-11

申请人： LIGAND PHARM INC

发明人： ZHI LIN

IPC分类号： C07F9/6571 ,  A61K9/00 ,  A61K31/661 ,  A61K31/6615 ,  A61K31/663 ,  A61K31/675 ,  A61K31/7072 ,  C07F9/09 ,  C07F9/655 ,  C07F9/6574 ,  C07F9/6584

CPC分类号： A61K31/7072 ,  A61K9/0053 ,  A61K31/661 ,  A61K31/6615 ,  A61K31/663 ,  A61K31/675 ,  C07F9/091 ,  C07F9/098 ,  C07F9/65515 ,  C07F9/657154 ,  C07F9/657181 ,  C07F9/65744 ,  C07F9/65746 ,  C07F9/65842 ,  C07F9/65844 ,  C07F9/65846 ,  A61K2300/00

摘要： Provided herein are prodrug compounds, their preparation and their uses, such as treating liver diseases or nonliver diseases via intervening in molecular pathways in the liver. Novel prodrug compounds of acid/alcohol derivatives such as phosphates, phosphonates, phosphonamidates, phosphoramidates, carboxylates, phenolates, and alkoxylates, their preparation and their uses are described. Some of the novel prodrug compounds described herein do not generate a vinyl keto reactive intermediate in the activation process. Another aspect includes the use of prodrugs to treat diseases that benefit from enhanced drug distribution to the liver and like tissues and cells.

公开(公告)号：EP3238903A1

公开(公告)日：2017-11-01

申请号：EP15873312.1

申请日：2015-12-25

申请人： Mitsui Chemicals, Inc.

发明人： OKAZAKI, Kouju ,  KAKINUMA, Naoyuki ,  OIKI, Motoharu

IPC分类号： B29C39/02 ,  C08F2/44 ,  C08G75/02 ,  C08K5/521 ,  C08L75/04 ,  C08L101/00 ,  G02B1/04 ,  G02B3/00 ,  B29L11/00

CPC分类号： B29C39/02 ,  B29C33/60 ,  C07F9/091 ,  C08F2/44 ,  C08G18/3876 ,  C08G75/02 ,  C08G2125/00 ,  C08K5/521 ,  C08L75/04 ,  C08L101/00 ,  C08L2666/40 ,  G02B1/04 ,  G02B1/041 ,  G02B3/00

摘要： An internal release agent of the present invention includes at least one phosphodiester represented by the following general formula (1).

(In the formula, R 1 and R 2 independently represent a hydrocarbon group having 1 to 30 carbon atoms, which is optionally substituted with at least one hydroxyl group, and R 3 represents an alkylene group having 2 to 4 carbon atoms. A plurality of R 3 's may be the same as or different from each other. M represents a hydrogen atom, an ammonium ion, an alkali metal ion, or a monovalent/divalent alkali earth metal ion, and n is an integer of 1 to 60.)

摘要翻译： 本发明的内部脱模剂含有至少一种下述通式（1）所示的磷酸二酯。 （式中，R 1和R 2分别独立地表示碳原子数1〜30的烃基，其可以被1个以上的羟基取代，R 3表示碳原子数2〜4的亚烷基，多个R 3可以是 M表示氢原子，铵离子，碱金属离子或1价/ 2价碱土金属离子，n表示1〜60的整数。）

公开(公告)号：EP3106465A4

公开(公告)日：2017-08-09

申请号：EP15746936

申请日：2015-02-05

申请人： ENZYTECH LTD

发明人： HWANG SOON OOK ,  YUN DAE MYOUNG

IPC分类号： C07F9/655 ,  C07C211/63 ,  C07F9/09 ,  C07F9/38 ,  C07F9/6574

CPC分类号： C07F9/10 ,  C07B2200/07 ,  C07F9/091 ,  C07F9/3808 ,  C07F9/65515 ,  C07F9/65742

摘要： The present invention relates to a method of preparing racemic or optically active D or L-±-glycerophosphorylcholine in large amounts by subjecting choline phosphate or a salt thereof, and racemic or optically highly pure (S) or (R)-3-halo-1,2-propanediol to a substitution reaction in a medium at high temperature in the presence of an inorganic base which increases the activity of the reaction. The method for preparing racemic or optically active D or L-±-glycerophosphorylcholine is cost-effective because of the use of starting materials which are inexpensive compared to those in a conventional method. Moreover, the method is simple and convenient because it is performed via a one-pot reaction without a separate purification process. In addition, it enables a large amount of racemic or optically active D or L-±-glycerophosphorylcholine, or a salt thereof, to be quantitatively produced in a medium without side reactions by using the inorganic base which increases the reaction activity.

摘要翻译： 本发明涉及一种通过将磷酸胆碱或其盐，以及外消旋或光学高度纯的（S）或（R）-3-卤代-β-甘油磷酸胆碱进行大量制备外消旋或旋光的D或L-甘油磷酸胆碱的方法， 1,2-丙二醇在高温下在无机碱存在下在介质中进行取代反应，这提高了反应的活性。 制备外消旋或光学活性的D或L-甘油磷酸胆碱的方法由于使用与常规方法相比便宜的原料而具有成本效益。 此外，该方法简单方便，因为其通过单罐反应进行而无需单独的纯化过程。 此外，通过使用提高反应活性的无机碱，它能够在没有副反应的介质中定量产生大量外消旋或旋光的D或L-甘油磷酸胆碱或其盐。

公开(公告)号：EP2828354B1

公开(公告)日：2017-08-09

申请号：EP13765124.6

申请日：2013-03-21

申请人： LG Hausys, Ltd.

发明人： YANG, In Suk ,  LEE, Jong Cheol

IPC分类号： C09K21/12 ,  C07F9/09 ,  C08K5/521

CPC分类号： C08K5/521 ,  C07F9/091 ,  C09K21/12

公开(公告)号：EP3193171A1

公开(公告)日：2017-07-19

申请号：EP15840489.7

申请日：2015-09-08

申请人： NOF Corporation

发明人： NAKASHIMA Fumio ,  YAMADA Satoshi ,  NODA Tomozumi ,  MATSUDA Masaru

IPC分类号： G01N33/531 ,  C07F9/09

CPC分类号： G01N33/15 ,  C07F9/091 ,  C07F9/10

摘要： There is provided a protein adsorption inhibitor comprising a compound represented by Formula (1) as an active ingredient. The protein adsorption inhibitor is capable of highly inhibiting non-specific adsorption of a protein such as an antibody or an enzyme to a surface of a base body such as an immune reaction vessel or an assay instrument. There is further provided a coating layer-formed base body having a coating layer containing the protein adsorption inhibitor on the base body. The coating layer-formed base body has an excellent protein adsorption-inhibiting function. There is still further provided a method for inhibiting the adsorption of the protein to the base body comprising forming the coating layer containing the protein adsorption inhibitor on the surface of the base body.

In Formula (1), X is a hydrogen atom or a methyl group and n is an integer of 9 to 15.

摘要翻译： 提供了含有式（1）所示化合物作为有效成分的蛋白吸附抑制剂。 蛋白质吸附抑制剂能够高度抑制抗体或酶等蛋白质向免疫反应容器，检测仪器等基体表面的非特异性吸附。 还提供了一种形成涂层的基体，该基体具有在基体上包含蛋白质吸附抑制剂的涂层。 形成涂层的基体具有优异的蛋白质吸附抑制功能。 还提供了一种抑制蛋白质吸附到基体上的方法，包括在基体表面上形成含有蛋白质吸附抑制剂的涂层。 式（1）中，X为氢原子或甲基，n为9〜15的整数。