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公开(公告)号：EP0421455A1
公开(公告)日：1991-04-10
申请号：EP90119127.0
申请日：1990-10-05
摘要： A deletion type mutein of heparin-binding secretory transforming factor (hst-1) possesses excellent cell growth promoting activity and is stable. The present mutein can therefore be used as a therapeutic medicine such as a healing promoter for burns, wounds, surgical injuries etc.
摘要翻译： 肝素结合分泌转化因子（hst-1）的缺失型突变蛋白具有优异的细胞生长促进活性，稳定。 因此，本发明的突变蛋白可用作治疗药物，例如用于烧伤，伤口，手术伤害等的治疗促进剂。
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公开(公告)号：EP0421455B1
公开(公告)日：1995-04-05
申请号：EP90119127.0
申请日：1990-10-05
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公开(公告)号：EP0488196A3
公开(公告)日：1993-04-07
申请号：EP91120244.8
申请日：1991-11-27
摘要： Disclosed are (1) an HST2 protein; (2) a recombinant DNA containing a nucleotide sequence coding for the HST2 protein; (3) a vector containing the recombinant DNA; (4) a transformant transformed with the vector; and (5) a method for preparing the protein which comprises cultivating the transformant and accumulating the protein in a culture broth, whereby the HST2 protein can be produced in high purity and in large amounts which is applicable to wound healing, or repair of the cardiac muscle or the nervous tissue after ischemia.
摘要翻译： 公开了（1）HST2蛋白; （2）含有编码HST2蛋白的核苷酸序列的重组DNA; （3）含有重组DNA的载体; （4）用载体转化的转化体; （5）一种蛋白质的制备方法，其特征在于，培养上述转化体并在培养液中积聚蛋白质，从而能够以高纯度，大量生产适用于伤口愈合或心脏修复的HST2蛋白质 肌肉或神经组织缺血后。
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4.发明公开HST-2, a member of the heparin binding growth factor family 失效HST-2，ein Mitglied der Heparin-bindenden Wachstumsfaktoren-Familie。
公开(公告)号：EP0488196A2
公开(公告)日：1992-06-03
申请号：EP91120244.8
申请日：1991-11-27
摘要： Disclosed are (1) an HST2 protein; (2) a recombinant DNA containing a nucleotide sequence coding for the HST2 protein; (3) a vector containing the recombinant DNA; (4) a transformant transformed with the vector; and (5) a method for preparing the protein which comprises cultivating the transformant and accumulating the protein in a culture broth, whereby the HST2 protein can be produced in high purity and in large amounts which is applicable to wound healing, or repair of the cardiac muscle or the nervous tissue after ischemia.
摘要翻译： 公开了（1）HST2蛋白; （2）含有编码HST2蛋白的核苷酸序列的重组DNA; （3）含有重组DNA的载体; （4）用载体转化的转化体; （5）一种蛋白质的制备方法，其特征在于，培养上述转化体并在培养液中积聚蛋白质，从而能够以高纯度，大量生产适用于伤口愈合或心脏修复的HST2蛋白质 肌肉或神经组织缺血后。
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