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1.发明公开PROTEASE-RESISTANT SEB VARIANT AND VACCINE CONTAINING THE SAME 有权耐腐蚀SEB-VARIANTE在DIESE ENTHALTENDER IMPFSTOFF
公开(公告)号：EP1661911A1
公开(公告)日：2006-05-31
申请号：EP04772501.5
申请日：2004-08-31
发明人： NAKASHIMA, Toshihiro c/o JURIDICAL FOUNDATION THE , SASAKI, Takumi c/o JURIDICAL FOUNDATION THE , NISHIHARA, Tsukasa c/o JURIDICAL FOUNDATION THE , TAKEMOTO, Sumiyo c/o JURIDICAL FOUNDATION THE , SAKATA, Atsuko , OHKUCHI, Masao , KOSHI, Tomoyuki , EDANO, Toshiyuki
IPC分类号： C07K14/31 , A61K39/085 , A61P37/08 , C12N15/31
摘要： A modified Staphylococcal enterotoxin B (SEB) having resistance to a protease and a reduced toxicity and a vaccine comprising said modified SEB are provided. A modified SEB which has an amino acid sequence as set forth in SEQ ID NO: 1 wherein each of the lysine at 97-position and the lysine at 98-position are substituted with any other amino acid, or a derivative thereof and a vaccine comprising said modified SEB or a derivative thereof.
摘要翻译： 提供了具有对蛋白酶的抗性和毒性降低的改良的葡萄球菌肠毒素B（SEB）和包含所述修饰的SEB的疫苗。 具有如SEQ ID NO：1所示的氨基酸序列的修饰SEB，其中97位的赖氨酸和98位的赖氨酸被任何其它氨基酸或其衍生物取代，并且包含 所述经修饰的SEB或其衍生物。
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公开(公告)号：EP1661911B1
公开(公告)日：2012-11-07
申请号：EP04772501.5
申请日：2004-08-31
发明人： NAKASHIMA, Toshihiro c/o JURIDICAL FOUNDATION THE , SASAKI, Takumi c/o JURIDICAL FOUNDATION THE , NISHIHARA, Tsukasa c/o JURIDICAL FOUNDATION THE , TAKEMOTO, Sumiyo c/o JURIDICAL FOUNDATION THE , SAKATA, Atsuko , OHKUCHI, Masao , KOSHI, Tomoyuki , EDANO, Toshiyuki
IPC分类号： C07K14/31 , A61K39/085 , A61P37/08 , C12N15/31
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3.发明授权SEB MODIFICATION AND PREVENTIVE/REMEDY FOR DISEASES WITH IMMUNE ABNORMALITY CONTAINING THE SAME 有权SEB修饰和那些含有预防剂/治疗与疾病WITH AIMMUNANOMALITÄT
公开(公告)号：EP1609860B1
公开(公告)日：2010-03-17
申请号：EP04723360.6
申请日：2004-03-25
发明人： NAKASHIMA, Toshihiro, c/o Juridical Foundation , SASAKI, Takumi, c/o Juridical Foundation , KIMACHI, Kazuhiko, c/o Juridical Foundation , KUWATA, Shigeki, c/o Juridical Foundation , NISHIHARA, Tsukasa, c/o Juridical Foundation , SAKATA, Atsuko , OHKUCHI, Masao , KOSHI, Tomoyuki , EDANO, Toshiyuki
CPC分类号： A61K38/164 , C07K14/31 , C07K16/1271
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公开(公告)号：EP1661911B8
公开(公告)日：2013-02-13
申请号：EP04772501.5
申请日：2004-08-31
发明人： NAKASHIMA, Toshihiro c/o JURIDICAL FOUNDATION THE , SASAKI, Takumi c/o JURIDICAL FOUNDATION THE , NISHIHARA, Tsukasa c/o JURIDICAL FOUNDATION THE , TAKEMOTO, Sumiyo c/o JURIDICAL FOUNDATION THE , SAKATA, Atsuko , OHKUCHI, Masao , KOSHI, Tomoyuki , EDANO, Toshiyuki
IPC分类号： C07K14/31 , A61K39/085 , A61P37/08 , C12N15/31
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5.发明公开SEB MODIFICATION AND PREVENTIVE/REMEDY FOR DISEASES WITH IMMUNE ABNORMALITY CONTIANING THE SAME 有权SEB修饰和那些含有预防剂/治疗与疾病WITH AIMMUNANOMALITÄT
公开(公告)号：EP1609860A1
公开(公告)日：2005-12-28
申请号：EP04723360.6
申请日：2004-03-25
发明人： NAKASHIMA, Toshihiro, Juridical Foundation , SASAKI, Takumi, Juridical Foundation , KIMACHI, Kazuhiko, Juridical Foundation , KUWATA, Shigeki, Juridical Foundation , NISHIHARA, Tsukasa, Juridical Foundation , SAKATA, Atsuko , OHKUCHI, Masao , KOSHI, Tomoyuki , EDANO, Toshiyuki
CPC分类号： A61K38/164 , C07K14/31 , C07K16/1271
摘要： A novel prophylactic/remedy for immunopathy is provided which is not neutralized by a neutralizing antibody to Staphylococcal enterotoxin B (SEB), known as one of superantigens, and may effectively act as a superantigen. A modified SEB having a reduced reactivity with a neutralizing antibody to SEB (anti-SEB antibody) and a prophylactic/remedy for immunopathy comprising as an active ingredient said modified SEB. The modified SEB of the present invention may be prepared with the evolutionary molecular engineering technique by introducing amino acid substitution in the amino acid sequence of SEB, especially at an epitope recognition site of the anti-SEB antibody in the amino acid sequence of SEB.
摘要翻译： 用于免疫疾病的新型的预防/治疗剂是所有未通过中和抗体来葡萄球菌肠毒素B（SEB），被称为超抗原的一种中提供，并且可以有效地充当超抗原。 具有的中和抗体，以SEB（抗SEB抗体）和用于免疫疾病包含作为活性成分的预防/治疗剂，降低的反应性的改性SEB所述改性SEB。 本发明的改性SEB可与由在SEB的氨基酸序列中引入氨基酸取代的进化分子工程技术来制备，爱特别是在对SEB的氨基酸序列中的抗SEB抗体的表位识别位点。
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